IL-4-Independent Inhibition of IL-12 Responsiveness During Leishmania amazonensis Infection

Leishmania amazonensis induces a nonhealing infection in C3H mice, whereas infection with Leishmania major is self-healing. We found that C3H mice infected with L. amazonensis exhibited decreased IL-12 production, which could account for the susceptibility to this organism. However, exogenous IL-12...

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Veröffentlicht in:	The Journal of immunology (1950) 2000-07, Vol.165 (1), p.364-372
Hauptverfasser:	Jones, Douglas E, Buxbaum, Laurence U, Scott, Phillip
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Animals Antigens, Protozoan - immunology CD4 antigen CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - parasitology CD4-Positive T-Lymphocytes - pathology Down-Regulation - genetics Down-Regulation - immunology Female Genetic Predisposition to Disease Injections, Subcutaneous Interferon-gamma - biosynthesis Interleukin 12 receptors Interleukin-12 - administration & dosage Interleukin-12 - antagonists & inhibitors Interleukin-12 - biosynthesis Interleukin-12 - physiology Interleukin-4 - deficiency Interleukin-4 - genetics Interleukin-4 - physiology Leishmania amazonensis Leishmania major - immunology Leishmania mexicana - immunology Leishmaniasis, Cutaneous - etiology Leishmaniasis, Cutaneous - genetics Leishmaniasis, Cutaneous - immunology Leishmaniasis, Cutaneous - metabolism Lymph Nodes - immunology Lymph Nodes - parasitology Lymph Nodes - pathology Lymphocyte Activation Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred C57BL Mice, Knockout Receptors, Interleukin - antagonists & inhibitors Receptors, Interleukin - biosynthesis Receptors, Interleukin - deficiency Receptors, Interleukin - genetics Receptors, Interleukin-12 RNA, Messenger - biosynthesis Signal Transduction - immunology Th1 Cells - drug effects Th1 Cells - immunology Th1 Cells - metabolism
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