Spatial Orientation and Dynamics of the U1A Proteins in the U1A−UTR Complex

The human U1A protein contains three distinct domains:  the N-terminal RBD1 (amino acids 1−101), the C-terminal RBD2 (amino acids 195−282), and the linker region (amino acids 102−194). The RBD1 domains of two U1A proteins bind specifically to two internal loops in the 3‘ untranslated region (3‘ UTR)...

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Veröffentlicht in:	Biochemistry (Easton) 2000-06, Vol.39 (24), p.7320-7329
Hauptverfasser:	Clerte, Caroline, Hall, Kathleen B
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - metabolism Amino Acid Sequence Base Sequence Fluorescence Polarization Fluorescent Dyes Humans Molecular Sequence Data Nucleic Acid Conformation Ribonucleoprotein, U1 Small Nuclear - chemistry Ribonucleoproteins - chemistry RNA Precursors - chemistry RNA-Binding Proteins - chemistry Tryptophan - chemistry
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