Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease

Prolonged immunodeficiency after allogeneic bone marrow transplantation (BMT) causes significant morbidity and mortality from infection. This study examined in murine models the effects of interleukin-7 (IL-7) given to young and middle-aged (9-month-old) recipients of major histocompatibility comple...

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Veröffentlicht in:	Blood 2001-10, Vol.98 (7), p.2256-2265
Hauptverfasser:	Alpdogan, Onder, Schmaltz, Cornelius, Muriglan, Stephanie J., Kappel, Barry J., Perales, Miguel-Angel, Rotolo, Jimmy A., Halm, Jens A., Rich, Benjamin E., van den Brink, Marcel R.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - drug effects Bone Marrow Transplantation - adverse effects Bone Marrow Transplantation - immunology Bone Marrow Transplantation - methods Cytokines - drug effects Graft vs Host Disease - etiology Graft vs Leukemia Effect Immune System - cytology Immune System - drug effects Interleukin-7 - administration & dosage Mice Mice, Inbred Strains T-Lymphocyte Subsets - cytology T-Lymphocyte Subsets - drug effects T-Lymphocytes - drug effects Thymus Gland - cytology Thymus Gland - drug effects Transplantation, Homologous - adverse effects Transplantation, Homologous - methods
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