Profile of glycosaminoglycan‐degrading glycosidases and glycoside sulfatases secreted by human articular chondrocytes in homeostasis and inflammation

Objective To determine enzymatic activities of the 8 key glycosaminoglycan‐degrading glycosidases and glycoside sulfatases in cultured human articular chondrocytes and in synovial fluid from patients with osteoarthritis. Methods The following enzymes were analyzed: hexosaminidase and its isoenzyme A...

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Veröffentlicht in:	Arthritis and rheumatism 2000-06, Vol.43 (6), p.1307-1314
Hauptverfasser:	Shikhman, Alexander R., Brinson, Diana C., Lotz, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - physiology beta-N-Acetylhexosaminidases - metabolism Biological and medical sciences Cartilage, Articular - drug effects Cartilage, Articular - enzymology Cartilage, Articular - pathology Cells, Cultured Chondrocytes - drug effects Chondrocytes - enzymology Chondrocytes - physiology Diseases of the osteoarticular system Extracellular Space - enzymology Glycosaminoglycans - metabolism Glycoside Hydrolases - metabolism Glycosides - metabolism Homeostasis - physiology Humans Hydrogen-Ion Concentration Inflammation Mediators - pharmacology Interleukin-1 - pharmacology Medical sciences Osteoarthritis Osteoarthritis - enzymology Osteoarthritis - pathology Reference Values Space life sciences Sulfatases - metabolism Synovial Fluid - enzymology
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