Galectine-1 expression in cochleae of C57BL/6 mice during aging
Presbycusis is a progressive hearing loss related to the aging process associated with auditory receptor degeneration. Adult animals exhibited galectine-1 (GAL-1) expression in epithelial cells of the inner and outer spiral sulci and Hensen cells, which was absent from the sensory and supporting cel...
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| Veröffentlicht in: | Neuroreport 2001-10, Vol.12 (14), p.3107-3110 |
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| creator | Bartolomé, Maria Visitación López, Lorena Maestre Gil-Loyzaga, Pablo |
| description | Presbycusis is a progressive hearing loss related to the aging process associated with auditory receptor degeneration. Adult animals exhibited galectine-1 (GAL-1) expression in epithelial cells of the inner and outer spiral sulci and Hensen cells, which was absent from the sensory and supporting cells. The progressive age-related degeneration of auditory receptor was analyzed using an anti-GAL-1 monoclonal antibody on cochleae of C57BL/6 mice (1–24 months old). Mice ≤ 9 months old showed adult and healthy auditory receptors, with a similar GAL-1 expression along the time. Conversely, animals > 1 year old exhibited a sensory degeneration at the cochleae basal coil that progressively reached the middle coil. Older animals (18–24 months old) showed a single layer epithelium that replaced the auditory receptor. The age-related degenerative process of the auditory receptor involves sensory but also supporting cells, which are both substituted by epithelial non-specialized cells. |
| doi_str_mv | 10.1097/00001756-200110080-00025 |
| format | Article |
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Adult animals exhibited galectine-1 (GAL-1) expression in epithelial cells of the inner and outer spiral sulci and Hensen cells, which was absent from the sensory and supporting cells. The progressive age-related degeneration of auditory receptor was analyzed using an anti-GAL-1 monoclonal antibody on cochleae of C57BL/6 mice (1–24 months old). Mice ≤ 9 months old showed adult and healthy auditory receptors, with a similar GAL-1 expression along the time. Conversely, animals > 1 year old exhibited a sensory degeneration at the cochleae basal coil that progressively reached the middle coil. Older animals (18–24 months old) showed a single layer epithelium that replaced the auditory receptor. The age-related degenerative process of the auditory receptor involves sensory but also supporting cells, which are both substituted by epithelial non-specialized cells.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-200110080-00025</identifier><identifier>PMID: 11568646</identifier><language>eng</language><publisher>England: Lippincott Williams & Wilkins, Inc</publisher><subject>Aging - metabolism ; Aging - pathology ; Animals ; Cochlea - metabolism ; Cochlea - pathology ; Cochlea - ultrastructure ; Galectin 1 ; Hair Cells, Auditory, Inner - metabolism ; Hair Cells, Auditory, Inner - pathology ; Hair Cells, Auditory, Inner - ultrastructure ; Hair Cells, Auditory, Outer - metabolism ; Hair Cells, Auditory, Outer - pathology ; Hair Cells, Auditory, Outer - ultrastructure ; Hearing - physiology ; Hemagglutinins - metabolism ; Immunohistochemistry ; Mice ; Mice, Inbred C57BL - anatomy & histology ; Mice, Inbred C57BL - metabolism ; Microscopy, Electron ; Nerve Degeneration - metabolism ; Nerve Degeneration - pathology ; Nerve Degeneration - physiopathology ; Presbycusis - metabolism ; Presbycusis - pathology ; Presbycusis - physiopathology</subject><ispartof>Neuroreport, 2001-10, Vol.12 (14), p.3107-3110</ispartof><rights>2001 Lippincott Williams & Wilkins, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2715-5960fdca7db61d8504be98eb5850b64f1bad63ddcab9aabf779a69bd8a46a463</citedby><cites>FETCH-LOGICAL-c2715-5960fdca7db61d8504be98eb5850b64f1bad63ddcab9aabf779a69bd8a46a463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11568646$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bartolomé, Maria Visitación</creatorcontrib><creatorcontrib>López, Lorena Maestre</creatorcontrib><creatorcontrib>Gil-Loyzaga, Pablo</creatorcontrib><title>Galectine-1 expression in cochleae of C57BL/6 mice during aging</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>Presbycusis is a progressive hearing loss related to the aging process associated with auditory receptor degeneration. Adult animals exhibited galectine-1 (GAL-1) expression in epithelial cells of the inner and outer spiral sulci and Hensen cells, which was absent from the sensory and supporting cells. The progressive age-related degeneration of auditory receptor was analyzed using an anti-GAL-1 monoclonal antibody on cochleae of C57BL/6 mice (1–24 months old). Mice ≤ 9 months old showed adult and healthy auditory receptors, with a similar GAL-1 expression along the time. Conversely, animals > 1 year old exhibited a sensory degeneration at the cochleae basal coil that progressively reached the middle coil. Older animals (18–24 months old) showed a single layer epithelium that replaced the auditory receptor. The age-related degenerative process of the auditory receptor involves sensory but also supporting cells, which are both substituted by epithelial non-specialized cells.</description><subject>Aging - metabolism</subject><subject>Aging - pathology</subject><subject>Animals</subject><subject>Cochlea - metabolism</subject><subject>Cochlea - pathology</subject><subject>Cochlea - ultrastructure</subject><subject>Galectin 1</subject><subject>Hair Cells, Auditory, Inner - metabolism</subject><subject>Hair Cells, Auditory, Inner - pathology</subject><subject>Hair Cells, Auditory, Inner - ultrastructure</subject><subject>Hair Cells, Auditory, Outer - metabolism</subject><subject>Hair Cells, Auditory, Outer - pathology</subject><subject>Hair Cells, Auditory, Outer - ultrastructure</subject><subject>Hearing - physiology</subject><subject>Hemagglutinins - metabolism</subject><subject>Immunohistochemistry</subject><subject>Mice</subject><subject>Mice, Inbred C57BL - anatomy & histology</subject><subject>Mice, Inbred C57BL - metabolism</subject><subject>Microscopy, Electron</subject><subject>Nerve Degeneration - metabolism</subject><subject>Nerve Degeneration - pathology</subject><subject>Nerve Degeneration - physiopathology</subject><subject>Presbycusis - metabolism</subject><subject>Presbycusis - pathology</subject><subject>Presbycusis - physiopathology</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUFPwyAUgInRuDn9C4aTNxy0BcrJ6KLTZImXHbwRaF-3Km0ntJn-e5mbevLlhfdCvgfJ9xDCjF4zquSUxmCSC5LEyijNKYk3CT9CY5bJlHCevxyjMVVckUwJPkJnIbxGRFGWn6IRY1zkIhNjdDM3Doq-boEwDB8bDyHUXYvrFhddsXZgAHcVnnF5t5gK3NQF4HLwdbvCZhXPc3RSGRfg4lAnaPlwv5w9ksXz_Gl2uyBFIhknXAlalYWRpRWszDnNLKgcLI-tFVnFrClFWkbCKmNsJaUyQtkyN5mImU7Q1f7Zje_eBwi9bupQgHOmhW4IWjKmaEJ3YL4HC9-F4KHSG183xn9qRvXOnf5xp3_d6W93cfTy8MdgGyj_Bg-yIpDtgW3nevDhzQ1b8HoNxvVr_d9O0i9G-XgZ</recordid><startdate>20011008</startdate><enddate>20011008</enddate><creator>Bartolomé, Maria Visitación</creator><creator>López, Lorena Maestre</creator><creator>Gil-Loyzaga, Pablo</creator><general>Lippincott Williams & Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20011008</creationdate><title>Galectine-1 expression in cochleae of C57BL/6 mice during aging</title><author>Bartolomé, Maria Visitación ; López, Lorena Maestre ; Gil-Loyzaga, Pablo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2715-5960fdca7db61d8504be98eb5850b64f1bad63ddcab9aabf779a69bd8a46a463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Aging - metabolism</topic><topic>Aging - pathology</topic><topic>Animals</topic><topic>Cochlea - metabolism</topic><topic>Cochlea - pathology</topic><topic>Cochlea - ultrastructure</topic><topic>Galectin 1</topic><topic>Hair Cells, Auditory, Inner - metabolism</topic><topic>Hair Cells, Auditory, Inner - pathology</topic><topic>Hair Cells, Auditory, Inner - ultrastructure</topic><topic>Hair Cells, Auditory, Outer - metabolism</topic><topic>Hair Cells, Auditory, Outer - pathology</topic><topic>Hair Cells, Auditory, Outer - ultrastructure</topic><topic>Hearing - physiology</topic><topic>Hemagglutinins - metabolism</topic><topic>Immunohistochemistry</topic><topic>Mice</topic><topic>Mice, Inbred C57BL - anatomy & histology</topic><topic>Mice, Inbred C57BL - metabolism</topic><topic>Microscopy, Electron</topic><topic>Nerve Degeneration - metabolism</topic><topic>Nerve Degeneration - pathology</topic><topic>Nerve Degeneration - physiopathology</topic><topic>Presbycusis - metabolism</topic><topic>Presbycusis - pathology</topic><topic>Presbycusis - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bartolomé, Maria Visitación</creatorcontrib><creatorcontrib>López, Lorena Maestre</creatorcontrib><creatorcontrib>Gil-Loyzaga, Pablo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bartolomé, Maria Visitación</au><au>López, Lorena Maestre</au><au>Gil-Loyzaga, Pablo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Galectine-1 expression in cochleae of C57BL/6 mice during aging</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>2001-10-08</date><risdate>2001</risdate><volume>12</volume><issue>14</issue><spage>3107</spage><epage>3110</epage><pages>3107-3110</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>Presbycusis is a progressive hearing loss related to the aging process associated with auditory receptor degeneration. Adult animals exhibited galectine-1 (GAL-1) expression in epithelial cells of the inner and outer spiral sulci and Hensen cells, which was absent from the sensory and supporting cells. The progressive age-related degeneration of auditory receptor was analyzed using an anti-GAL-1 monoclonal antibody on cochleae of C57BL/6 mice (1–24 months old). Mice ≤ 9 months old showed adult and healthy auditory receptors, with a similar GAL-1 expression along the time. Conversely, animals > 1 year old exhibited a sensory degeneration at the cochleae basal coil that progressively reached the middle coil. Older animals (18–24 months old) showed a single layer epithelium that replaced the auditory receptor. The age-related degenerative process of the auditory receptor involves sensory but also supporting cells, which are both substituted by epithelial non-specialized cells.</abstract><cop>England</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>11568646</pmid><doi>10.1097/00001756-200110080-00025</doi><tpages>4</tpages></addata></record> |
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| subjects | Aging - metabolism Aging - pathology Animals Cochlea - metabolism Cochlea - pathology Cochlea - ultrastructure Galectin 1 Hair Cells, Auditory, Inner - metabolism Hair Cells, Auditory, Inner - pathology Hair Cells, Auditory, Inner - ultrastructure Hair Cells, Auditory, Outer - metabolism Hair Cells, Auditory, Outer - pathology Hair Cells, Auditory, Outer - ultrastructure Hearing - physiology Hemagglutinins - metabolism Immunohistochemistry Mice Mice, Inbred C57BL - anatomy & histology Mice, Inbred C57BL - metabolism Microscopy, Electron Nerve Degeneration - metabolism Nerve Degeneration - pathology Nerve Degeneration - physiopathology Presbycusis - metabolism Presbycusis - pathology Presbycusis - physiopathology |
| title | Galectine-1 expression in cochleae of C57BL/6 mice during aging |
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