Bradykinin-Induced Vasodilation of Human Forearm Resistance Vessels Is Primarily Mediated by Endothelium-Dependent Hyperpolarization

Bradykinin (BK) stimulates endothelial cells to release a number of relaxing factors, such as NO, prostanoids (PGs), and an endothelium-derived hyperpolarizing factor (EDHF). However, the contributions of NO, PG, and EDHF in the vascular relaxation to BK vary with species and anatomic origin of bloo...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2000-06, Vol.35 (6), p.1314-1318
Hauptverfasser:	Honing, Marina L. H, Smits, Paul, Morrison, Paul J, Rabelink, Ton J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Biological and medical sciences Brachial Artery - drug effects Brachial Artery - physiology Bradykinin - pharmacology Cyclooxygenase Inhibitors - pharmacology Electrophysiology Endothelium, Vascular - physiology Enzyme Inhibitors - pharmacology Forearm - blood supply Fundamental and applied biological sciences. Psychology Hemodynamics. Rheology Humans Middle Aged Nitric Oxide - antagonists & inhibitors Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase Type III Nitroprusside - pharmacology omega-N-Methylarginine - pharmacology Potassium Channel Blockers Serotonin - pharmacology Tetraethylammonium - pharmacology Vascular Resistance Vasodilation Vertebrates: cardiovascular system
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