Platinum(II) complexes with 2-acetyl pyridine thiosemicarbazone: Synthesis, crystal structure, spectral properties, antimicrobial and antitumour activity

An interesting series of new platinum complexes has been synthesized by the reaction of Na 2PtCl 4 with 2-acetyl pyridine thiosemicarbazone, HAcTsc. The new complexes, [Pt(AcTsc)Cl], [Pt(HAcTsc) 2]Cl 2 and [Pt(AcTsc) 2], have been characterized by elemental analyses and spectroscopic studies. The cr...

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Veröffentlicht in:	Journal of inorganic biochemistry 2001-09, Vol.86 (2), p.555-563
Hauptverfasser:	Kovala-Demertzi, Dimitra, Demertzis, Mavroudis A, Miller, J.R, Papadopoulou, Cryshanthi, Dodorou, Catherine, Filousis, Giorge
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Sprache:	eng
Schlagworte:	Anti-Bacterial Agents Anti-Infective Agents - chemical synthesis Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Antibacterial, antifungal, antineoplastic activity Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Candida albicans - drug effects Crystal structure Crystallography, X-Ray Escherichia coli - drug effects Magnetic Resonance Spectroscopy Molecular Structure Organoplatinum Compounds - chemical synthesis Organoplatinum Compounds - chemistry Organoplatinum Compounds - pharmacology Platinum(II) complex Spectrophotometry Spectroscopic study Staphylococcus aureus - drug effects Thiosemicarbazonato complex Thiosemicarbazones - chemical synthesis Thiosemicarbazones - chemistry Thiosemicarbazones - pharmacology
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container_title	Journal of inorganic biochemistry
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creator	Kovala-Demertzi, Dimitra Demertzis, Mavroudis A Miller, J.R Papadopoulou, Cryshanthi Dodorou, Catherine Filousis, Giorge
description	An interesting series of new platinum complexes has been synthesized by the reaction of Na 2PtCl 4 with 2-acetyl pyridine thiosemicarbazone, HAcTsc. The new complexes, [Pt(AcTsc)Cl], [Pt(HAcTsc) 2]Cl 2 and [Pt(AcTsc) 2], have been characterized by elemental analyses and spectroscopic studies. The crystal structure of the complex [Pt(AcTsc)Cl] has been solved by single-crystal X-ray diffraction. The anion of HAcTsc coordinates in a planar conformation to the central platinum(II) through the pyridyl N, azomethine N and thiolato S atoms. Double intermolecular hydrogen bonds (NH–Cl), π–π and weak Pt–Pt and Pt–π contacts lead to aggregation and to a two-dimensional supramolecular assembly. The antibacterial and antifungal effect of the novel platinum(II) complexes and the related palladium(II) complexes, [Pd(AcTsc)Cl], [Pd(HAcTsc) 2]Cl 2 and [Pd(AcTsc) 2], were studied in vitro. The complexes were found to have a completely lethal effect on Gram+ bacteria, while the same complexes showed no bactericidal effect on Gram− bacteria. Additionally, the complexes [Pt(AcTsc) 2] and [Pd(AcTsc) 2] showed effective antifungal activity towards yeast. Among these compounds [33], the most effective in inducing antitumour and cytogenetic effects are the complexes [Pt(AcTsc) 2] and [Pd(AcTsc) 2] while the rest, display marginal cytogenetic and antitumour effects.
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The new complexes, [Pt(AcTsc)Cl], [Pt(HAcTsc) 2]Cl 2 and [Pt(AcTsc) 2], have been characterized by elemental analyses and spectroscopic studies. The crystal structure of the complex [Pt(AcTsc)Cl] has been solved by single-crystal X-ray diffraction. The anion of HAcTsc coordinates in a planar conformation to the central platinum(II) through the pyridyl N, azomethine N and thiolato S atoms. Double intermolecular hydrogen bonds (NH–Cl), π–π and weak Pt–Pt and Pt–π contacts lead to aggregation and to a two-dimensional supramolecular assembly. The antibacterial and antifungal effect of the novel platinum(II) complexes and the related palladium(II) complexes, [Pd(AcTsc)Cl], [Pd(HAcTsc) 2]Cl 2 and [Pd(AcTsc) 2], were studied in vitro. The complexes were found to have a completely lethal effect on Gram+ bacteria, while the same complexes showed no bactericidal effect on Gram− bacteria. Additionally, the complexes [Pt(AcTsc) 2] and [Pd(AcTsc) 2] showed effective antifungal activity towards yeast. Among these compounds [33], the most effective in inducing antitumour and cytogenetic effects are the complexes [Pt(AcTsc) 2] and [Pd(AcTsc) 2] while the rest, display marginal cytogenetic and antitumour effects.</description><identifier>ISSN: 0162-0134</identifier><identifier>EISSN: 1873-3344</identifier><identifier>DOI: 10.1016/S0162-0134(01)00224-0</identifier><identifier>PMID: 11566327</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Anti-Bacterial Agents ; Anti-Infective Agents - chemical synthesis ; Anti-Infective Agents - chemistry ; Anti-Infective Agents - pharmacology ; Antibacterial, antifungal, antineoplastic activity ; Antifungal Agents - chemical synthesis ; Antifungal Agents - chemistry ; Antifungal Agents - pharmacology ; Antineoplastic Agents - chemical synthesis ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Candida albicans - drug effects ; Crystal structure ; Crystallography, X-Ray ; Escherichia coli - drug effects ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Organoplatinum Compounds - chemical synthesis ; Organoplatinum Compounds - chemistry ; Organoplatinum Compounds - pharmacology ; Platinum(II) complex ; Spectrophotometry ; Spectroscopic study ; Staphylococcus aureus - drug effects ; Thiosemicarbazonato complex ; Thiosemicarbazones - chemical synthesis ; Thiosemicarbazones - chemistry ; Thiosemicarbazones - pharmacology</subject><ispartof>Journal of inorganic biochemistry, 2001-09, Vol.86 (2), p.555-563</ispartof><rights>2001 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-61b297a3d886c03a2f86fa7090cf204b394fa3b6dc1540d82bcd0a1750ae03703</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0162013401002240$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11566327$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kovala-Demertzi, Dimitra</creatorcontrib><creatorcontrib>Demertzis, Mavroudis A</creatorcontrib><creatorcontrib>Miller, J.R</creatorcontrib><creatorcontrib>Papadopoulou, Cryshanthi</creatorcontrib><creatorcontrib>Dodorou, Catherine</creatorcontrib><creatorcontrib>Filousis, Giorge</creatorcontrib><title>Platinum(II) complexes with 2-acetyl pyridine thiosemicarbazone: Synthesis, crystal structure, spectral properties, antimicrobial and antitumour activity</title><title>Journal of inorganic biochemistry</title><addtitle>J Inorg Biochem</addtitle><description>An interesting series of new platinum complexes has been synthesized by the reaction of Na 2PtCl 4 with 2-acetyl pyridine thiosemicarbazone, HAcTsc. The new complexes, [Pt(AcTsc)Cl], [Pt(HAcTsc) 2]Cl 2 and [Pt(AcTsc) 2], have been characterized by elemental analyses and spectroscopic studies. The crystal structure of the complex [Pt(AcTsc)Cl] has been solved by single-crystal X-ray diffraction. The anion of HAcTsc coordinates in a planar conformation to the central platinum(II) through the pyridyl N, azomethine N and thiolato S atoms. Double intermolecular hydrogen bonds (NH–Cl), π–π and weak Pt–Pt and Pt–π contacts lead to aggregation and to a two-dimensional supramolecular assembly. The antibacterial and antifungal effect of the novel platinum(II) complexes and the related palladium(II) complexes, [Pd(AcTsc)Cl], [Pd(HAcTsc) 2]Cl 2 and [Pd(AcTsc) 2], were studied in vitro. The complexes were found to have a completely lethal effect on Gram+ bacteria, while the same complexes showed no bactericidal effect on Gram− bacteria. Additionally, the complexes [Pt(AcTsc) 2] and [Pd(AcTsc) 2] showed effective antifungal activity towards yeast. Among these compounds [33], the most effective in inducing antitumour and cytogenetic effects are the complexes [Pt(AcTsc) 2] and [Pd(AcTsc) 2] while the rest, display marginal cytogenetic and antitumour effects.</description><subject>Anti-Bacterial Agents</subject><subject>Anti-Infective Agents - chemical synthesis</subject><subject>Anti-Infective Agents - chemistry</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Antibacterial, antifungal, antineoplastic activity</subject><subject>Antifungal Agents - chemical synthesis</subject><subject>Antifungal Agents - chemistry</subject><subject>Antifungal Agents - pharmacology</subject><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Candida albicans - drug effects</subject><subject>Crystal structure</subject><subject>Crystallography, X-Ray</subject><subject>Escherichia coli - drug effects</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Molecular Structure</subject><subject>Organoplatinum Compounds - chemical synthesis</subject><subject>Organoplatinum Compounds - chemistry</subject><subject>Organoplatinum Compounds - pharmacology</subject><subject>Platinum(II) complex</subject><subject>Spectrophotometry</subject><subject>Spectroscopic study</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Thiosemicarbazonato complex</subject><subject>Thiosemicarbazones - chemical synthesis</subject><subject>Thiosemicarbazones - chemistry</subject><subject>Thiosemicarbazones - pharmacology</subject><issn>0162-0134</issn><issn>1873-3344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1rFTEQhoNY7LH6E5RcSQvdOkn26_RGpKg9UFCoXodsMssZ2S-TbHX9J_7b5nygl97MwOSZeSfzMvZKwJUAUb69T0FmIFR-DuICQMo8gydsJepKZUrl-VO2-oucsuchfAeAosirZ-xUiKIslaxW7M-XzkQa5v58s7ngduynDn9h4D8pbrnMjMW4dHxaPDkakMctjQF7ssY35vc44DW_X4a4xUDhklu_hGg6HqKfbZw9XvIwoY0-1SY_TugjYeLMECnN8GND6cUMbl-Jcz_Onhsb6YHi8oKdtKYL-PKYz9i3jx--3txmd58_bW7e32VWlSJmpWjkujLK1XVpQRnZ1mVrKliDbSXkjVrnrVFN6awocnC1bKwDI6oCDIKqQJ2xN4e5acMfM4aoewoWu84MOM5BV0LU60KKBBYHMC0egsdWT5564xctQO880XtP9O7gKei9J3on8PooMDc9un9dRxMS8O4AYPrmA6HXwRIOFh35dD3tRvqPxCM11Z8-</recordid><startdate>20010901</startdate><enddate>20010901</enddate><creator>Kovala-Demertzi, Dimitra</creator><creator>Demertzis, Mavroudis A</creator><creator>Miller, J.R</creator><creator>Papadopoulou, Cryshanthi</creator><creator>Dodorou, Catherine</creator><creator>Filousis, Giorge</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010901</creationdate><title>Platinum(II) complexes with 2-acetyl pyridine thiosemicarbazone: Synthesis, crystal structure, spectral properties, antimicrobial and antitumour activity</title><author>Kovala-Demertzi, Dimitra ; Demertzis, Mavroudis A ; Miller, J.R ; Papadopoulou, Cryshanthi ; Dodorou, Catherine ; Filousis, Giorge</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-61b297a3d886c03a2f86fa7090cf204b394fa3b6dc1540d82bcd0a1750ae03703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Anti-Bacterial Agents</topic><topic>Anti-Infective Agents - chemical synthesis</topic><topic>Anti-Infective Agents - chemistry</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Antibacterial, antifungal, antineoplastic activity</topic><topic>Antifungal Agents - chemical synthesis</topic><topic>Antifungal Agents - chemistry</topic><topic>Antifungal Agents - pharmacology</topic><topic>Antineoplastic Agents - chemical synthesis</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Candida albicans - drug effects</topic><topic>Crystal structure</topic><topic>Crystallography, X-Ray</topic><topic>Escherichia coli - drug effects</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Molecular Structure</topic><topic>Organoplatinum Compounds - chemical synthesis</topic><topic>Organoplatinum Compounds - chemistry</topic><topic>Organoplatinum Compounds - pharmacology</topic><topic>Platinum(II) complex</topic><topic>Spectrophotometry</topic><topic>Spectroscopic study</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Thiosemicarbazonato complex</topic><topic>Thiosemicarbazones - chemical synthesis</topic><topic>Thiosemicarbazones - chemistry</topic><topic>Thiosemicarbazones - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kovala-Demertzi, Dimitra</creatorcontrib><creatorcontrib>Demertzis, Mavroudis A</creatorcontrib><creatorcontrib>Miller, J.R</creatorcontrib><creatorcontrib>Papadopoulou, Cryshanthi</creatorcontrib><creatorcontrib>Dodorou, Catherine</creatorcontrib><creatorcontrib>Filousis, Giorge</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of inorganic biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kovala-Demertzi, Dimitra</au><au>Demertzis, Mavroudis A</au><au>Miller, J.R</au><au>Papadopoulou, Cryshanthi</au><au>Dodorou, Catherine</au><au>Filousis, Giorge</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Platinum(II) complexes with 2-acetyl pyridine thiosemicarbazone: Synthesis, crystal structure, spectral properties, antimicrobial and antitumour activity</atitle><jtitle>Journal of inorganic biochemistry</jtitle><addtitle>J Inorg Biochem</addtitle><date>2001-09-01</date><risdate>2001</risdate><volume>86</volume><issue>2</issue><spage>555</spage><epage>563</epage><pages>555-563</pages><issn>0162-0134</issn><eissn>1873-3344</eissn><abstract>An interesting series of new platinum complexes has been synthesized by the reaction of Na 2PtCl 4 with 2-acetyl pyridine thiosemicarbazone, HAcTsc. The new complexes, [Pt(AcTsc)Cl], [Pt(HAcTsc) 2]Cl 2 and [Pt(AcTsc) 2], have been characterized by elemental analyses and spectroscopic studies. The crystal structure of the complex [Pt(AcTsc)Cl] has been solved by single-crystal X-ray diffraction. The anion of HAcTsc coordinates in a planar conformation to the central platinum(II) through the pyridyl N, azomethine N and thiolato S atoms. Double intermolecular hydrogen bonds (NH–Cl), π–π and weak Pt–Pt and Pt–π contacts lead to aggregation and to a two-dimensional supramolecular assembly. The antibacterial and antifungal effect of the novel platinum(II) complexes and the related palladium(II) complexes, [Pd(AcTsc)Cl], [Pd(HAcTsc) 2]Cl 2 and [Pd(AcTsc) 2], were studied in vitro. The complexes were found to have a completely lethal effect on Gram+ bacteria, while the same complexes showed no bactericidal effect on Gram− bacteria. Additionally, the complexes [Pt(AcTsc) 2] and [Pd(AcTsc) 2] showed effective antifungal activity towards yeast. Among these compounds [33], the most effective in inducing antitumour and cytogenetic effects are the complexes [Pt(AcTsc) 2] and [Pd(AcTsc) 2] while the rest, display marginal cytogenetic and antitumour effects.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>11566327</pmid><doi>10.1016/S0162-0134(01)00224-0</doi><tpages>9</tpages></addata></record>
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subjects	Anti-Bacterial Agents Anti-Infective Agents - chemical synthesis Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Antibacterial, antifungal, antineoplastic activity Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Candida albicans - drug effects Crystal structure Crystallography, X-Ray Escherichia coli - drug effects Magnetic Resonance Spectroscopy Molecular Structure Organoplatinum Compounds - chemical synthesis Organoplatinum Compounds - chemistry Organoplatinum Compounds - pharmacology Platinum(II) complex Spectrophotometry Spectroscopic study Staphylococcus aureus - drug effects Thiosemicarbazonato complex Thiosemicarbazones - chemical synthesis Thiosemicarbazones - chemistry Thiosemicarbazones - pharmacology
title	Platinum(II) complexes with 2-acetyl pyridine thiosemicarbazone: Synthesis, crystal structure, spectral properties, antimicrobial and antitumour activity
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