Effector cytotoxic T lymphocyte numbers induced by vaccination should exceed levels in chronic infection for protection from HIV
Recent technological advances have revolutionised our capacity to induce cytotoxic T lymphocyte (CTL) responses with a variety of vaccine formulations and delivery systems. However, the conditions required for a CTL-inducing vaccine to provide protection from infection or disease are poorly understo...
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| Veröffentlicht in: | Vaccine 2001-10, Vol.20 (1), p.3-6 |
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| creator | Altes, Hester Korthals Price, David A. Jansen, Vincent A.A. |
| description | Recent technological advances have revolutionised our capacity to induce cytotoxic T lymphocyte (CTL) responses with a variety of vaccine formulations and delivery systems. However, the conditions required for a CTL-inducing vaccine to provide protection from infection or disease are poorly understood, and the results of challenge experiments have not been consistent. Here we use a mathematical model to examine the requirements necessary for successful vaccination against human immunodeficiency virus (HIV) through cellular immunity. We describe the interaction between cytotoxic T cells and infected lymphocytes, capturing the essence of a persistent infection of immune cells. We conclude that to protect from infection, the cellular immune response should be boosted to levels exceeding those in chronic infection. This requires either that effector CTL exceed this threshold before infection, or that a memory CTL population is established that can yield this level of effector CTL very quickly upon infection. |
| doi_str_mv | 10.1016/S0264-410X(01)00318-8 |
| format | Article |
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Psychology</subject><subject>General aspects</subject><subject>HIV Infections - prevention & control</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Lymphocyte Count</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Models, Immunological</subject><subject>Persistent infection</subject><subject>Prophylactic vaccine</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><subject>Vaccination</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><subject>Viremia - prevention & control</subject><subject>Virology</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtvEzEUhS0EoqHwE0DeUMFiiq_HYzsrhKq-pEosWhA7y_FDMZqxgz0TNTt-ej1NoMuurGt_99zjexB6D-QUCPAvt4Ry1jAgvz4R-ExIC7KRL9ACpGgb2oF8iRb_kSP0ppTfhJCuheVrdATQcSFasUB_z713ZkwZm92YxnQfDL7D_W7YrFO9cThOw8rlgkO0k3EWr3Z4q40JUY8hRVzWaeotdvfG1cfebV0_s9isc4pVK8RZfiZ9nbHJafxX5jTgq-ufb9Err_vi3h3OY_Tj4vzu7Kq5-X55ffbtpjGM0rEBZhn1lBvaLVmnwVrrhaaOSsLNstWSa-EFJ9rXP3pgwKQmYsWZFqKWuj1GJ3vd6uHP5MqohlCM63sdXZqKEgBy2UH3LAiSUiAEKtjtQZNTKdl5tclh0HmngKg5I_WYkZoDUATUY0ZK1r4PhwHTanD2qesQSgU-HgBdjO591tGE8sSx6pLLWejrnqs7d9vgsiomuFhTCrluWdkUnrHyAOxrr8c</recordid><startdate>20011012</startdate><enddate>20011012</enddate><creator>Altes, Hester Korthals</creator><creator>Price, David A.</creator><creator>Jansen, Vincent A.A.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20011012</creationdate><title>Effector cytotoxic T lymphocyte numbers induced by vaccination should exceed levels in chronic infection for protection from HIV</title><author>Altes, Hester Korthals ; Price, David A. ; Jansen, Vincent A.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-14d42f26c25945a1dddf7a2e2806c93a86a7f760af053f14148a07b64a77f14a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>AIDS Vaccines - immunology</topic><topic>Biological and medical sciences</topic><topic>CD4-Positive T-Lymphocytes - virology</topic><topic>Cellular immunity</topic><topic>Epidemiology. 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| identifier | ISSN: 0264-410X |
| ispartof | Vaccine, 2001-10, Vol.20 (1), p.3-6 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | AIDS Vaccines - immunology Biological and medical sciences CD4-Positive T-Lymphocytes - virology Cellular immunity Epidemiology. Vaccinations Fundamental and applied biological sciences. Psychology General aspects HIV Infections - prevention & control Human immunodeficiency virus Humans Infectious diseases Lymphocyte Count Medical sciences Microbiology Models, Immunological Persistent infection Prophylactic vaccine T-Lymphocytes, Cytotoxic - immunology Vaccination Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Viremia - prevention & control Virology |
| title | Effector cytotoxic T lymphocyte numbers induced by vaccination should exceed levels in chronic infection for protection from HIV |
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