Significant differences in the retention of the borocaptate monomer (BSH) and dimer (BSSB) in malignant cells
The (10)B enriched form of Na(2)B(12)H(11)SH (BSH) is used in a binary cancer radiation treatment, known as boron neutron capture therapy (BNCT). The BSH anion can also form a dimer, [B(24)H(22)S(2)](4-) (BSSB), previously used in animal model studies. It is demonstrated here that the retention of B...
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| Veröffentlicht in: | Cancer letters 2001-10, Vol.172 (2), p.127-132 |
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| container_title | Cancer letters |
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| creator | ELHANATI, Gila SALOMON, Yoram BENDEL, Peter |
| description | The (10)B enriched form of Na(2)B(12)H(11)SH (BSH) is used in a binary cancer radiation treatment, known as boron neutron capture therapy (BNCT). The BSH anion can also form a dimer, [B(24)H(22)S(2)](4-) (BSSB), previously used in animal model studies. It is demonstrated here that the retention of BSSB in mouse M2R melanoma and rat C6 glioma cells is significantly longer than that of the monomer BSH. The washout of the BNCT agents from cultured cells was followed using (11)B nuclear magnetic resonance spectroscopy. One hour after switching to boron-free culture medium, the relative amount of BSSB retained in M2R cells was at least about six times higher than that of BSH. The initial washout rate (over the first approximately 4 h) of BSSB was 4x10(-3) min(-1) (t(1/2), approximately 3 h) for M2R cells, and of the same order of magnitude for glioma cells. |
| doi_str_mv | 10.1016/S0304-3835(01)00649-8 |
| format | Article |
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The BSH anion can also form a dimer, [B(24)H(22)S(2)](4-) (BSSB), previously used in animal model studies. It is demonstrated here that the retention of BSSB in mouse M2R melanoma and rat C6 glioma cells is significantly longer than that of the monomer BSH. The washout of the BNCT agents from cultured cells was followed using (11)B nuclear magnetic resonance spectroscopy. One hour after switching to boron-free culture medium, the relative amount of BSSB retained in M2R cells was at least about six times higher than that of BSH. The initial washout rate (over the first approximately 4 h) of BSSB was 4x10(-3) min(-1) (t(1/2), approximately 3 h) for M2R cells, and of the same order of magnitude for glioma cells.</description><identifier>ISSN: 0304-3835</identifier><identifier>DOI: 10.1016/S0304-3835(01)00649-8</identifier><identifier>PMID: 11566486</identifier><identifier>CODEN: CALEDQ</identifier><language>eng</language><publisher>Shannon: Elsevier</publisher><subject>Animals ; Biological and medical sciences ; Biological effects of radiation ; Borohydrides - pharmacokinetics ; Boron Neutron Capture Therapy ; Dimerization ; Fundamental and applied biological sciences. 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The BSH anion can also form a dimer, [B(24)H(22)S(2)](4-) (BSSB), previously used in animal model studies. It is demonstrated here that the retention of BSSB in mouse M2R melanoma and rat C6 glioma cells is significantly longer than that of the monomer BSH. The washout of the BNCT agents from cultured cells was followed using (11)B nuclear magnetic resonance spectroscopy. One hour after switching to boron-free culture medium, the relative amount of BSSB retained in M2R cells was at least about six times higher than that of BSH. The initial washout rate (over the first approximately 4 h) of BSSB was 4x10(-3) min(-1) (t(1/2), approximately 3 h) for M2R cells, and of the same order of magnitude for glioma cells.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biological effects of radiation</subject><subject>Borohydrides - pharmacokinetics</subject><subject>Boron Neutron Capture Therapy</subject><subject>Dimerization</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glioma - metabolism</subject><subject>Ionizing radiations</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Melanoma, Experimental - metabolism</subject><subject>Mice</subject><subject>Rats</subject><subject>Sulfhydryl Compounds - pharmacokinetics</subject><subject>Tissues, organs and organisms biophysics</subject><subject>Tumor Cells, Cultured</subject><issn>0304-3835</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEFPwyAYhjlo3Jz-BA0XzXaoQlsYO7pFnckSD9UzYfChmBYmdAf_ve3W6Il8b57v4cuL0BUld5RQfl-RgpRZIQo2JXRGCC8XmThB4794hM5T-iKEsHLOztCIUsZ5KfgYNZX78M46rXyLjbMWIngNCTuP20_AEVrwrQseB3sItiEGrXatagE3wYcGIp4uq_UMK286wzBXy1mvaFTd-Xu3hrpOF-jUqjrB5fBO0PvT49tqnW1en19WD5tMFwVrM8Es0xZINwCxtqAcNOMGBM-1gNwYtp0vutBowQwrQQhQeQlUQa4Mmatigm6P3l0M33tIrWxc6i9QHsI-yTmlQjBBO5AdQR1DShGs3EXXqPgjKZF9t_LQrexLlITKQ7dSdHvXwwf7bQPmf2sotgNuBkAlrWobldcu_XMl4TxntPgFIk-EOw</recordid><startdate>20011030</startdate><enddate>20011030</enddate><creator>ELHANATI, Gila</creator><creator>SALOMON, Yoram</creator><creator>BENDEL, Peter</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20011030</creationdate><title>Significant differences in the retention of the borocaptate monomer (BSH) and dimer (BSSB) in malignant cells</title><author>ELHANATI, Gila ; SALOMON, Yoram ; BENDEL, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-85f5cfe0335e0ff316ec56de862c8e2dd5b7916edc85d54e88ea24e1ae2ad07a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biological effects of radiation</topic><topic>Borohydrides - pharmacokinetics</topic><topic>Boron Neutron Capture Therapy</topic><topic>Dimerization</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glioma - metabolism</topic><topic>Ionizing radiations</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Melanoma, Experimental - metabolism</topic><topic>Mice</topic><topic>Rats</topic><topic>Sulfhydryl Compounds - pharmacokinetics</topic><topic>Tissues, organs and organisms biophysics</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ELHANATI, Gila</creatorcontrib><creatorcontrib>SALOMON, Yoram</creatorcontrib><creatorcontrib>BENDEL, Peter</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ELHANATI, Gila</au><au>SALOMON, Yoram</au><au>BENDEL, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Significant differences in the retention of the borocaptate monomer (BSH) and dimer (BSSB) in malignant cells</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2001-10-30</date><risdate>2001</risdate><volume>172</volume><issue>2</issue><spage>127</spage><epage>132</epage><pages>127-132</pages><issn>0304-3835</issn><coden>CALEDQ</coden><abstract>The (10)B enriched form of Na(2)B(12)H(11)SH (BSH) is used in a binary cancer radiation treatment, known as boron neutron capture therapy (BNCT). The BSH anion can also form a dimer, [B(24)H(22)S(2)](4-) (BSSB), previously used in animal model studies. It is demonstrated here that the retention of BSSB in mouse M2R melanoma and rat C6 glioma cells is significantly longer than that of the monomer BSH. The washout of the BNCT agents from cultured cells was followed using (11)B nuclear magnetic resonance spectroscopy. One hour after switching to boron-free culture medium, the relative amount of BSSB retained in M2R cells was at least about six times higher than that of BSH. The initial washout rate (over the first approximately 4 h) of BSSB was 4x10(-3) min(-1) (t(1/2), approximately 3 h) for M2R cells, and of the same order of magnitude for glioma cells.</abstract><cop>Shannon</cop><pub>Elsevier</pub><pmid>11566486</pmid><doi>10.1016/S0304-3835(01)00649-8</doi><tpages>6</tpages></addata></record> |
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| ispartof | Cancer letters, 2001-10, Vol.172 (2), p.127-132 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Biological and medical sciences Biological effects of radiation Borohydrides - pharmacokinetics Boron Neutron Capture Therapy Dimerization Fundamental and applied biological sciences. Psychology Glioma - metabolism Ionizing radiations Magnetic Resonance Spectroscopy Melanoma, Experimental - metabolism Mice Rats Sulfhydryl Compounds - pharmacokinetics Tissues, organs and organisms biophysics Tumor Cells, Cultured |
| title | Significant differences in the retention of the borocaptate monomer (BSH) and dimer (BSSB) in malignant cells |
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