Characterisation of Non-P-Glycoprotein multidrug-resistant Ehrlich ascites tumour cells selected for resistance to mitoxantrone

An Ehrlich ascites tumour cell line (EHR2) was selected in vivo for resistance to mitoxantrone (MITOX). The resistant cell line (EHR2/MITOX) was 6123-, 33-, and 30-fold-resistant to mitoxantrone, daunorubicin, and etoposide, respectively, but retained sensitivity to vincristine. The resistant cells...

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Veröffentlicht in:	Biochemical pharmacology 2000-08, Vol.60 (3), p.363-370
Hauptverfasser:	Nielsen, Dorte, Eriksen, Jens, Maare, Christian, Litman, Thomas, Kjærsgaard, Erik, Plesner, Torben, Friche, Ellen, Skovsgaard, Torben
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - metabolism Animals Antineoplastic agents Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology ATP Binding Cassette Transporter, Subfamily B, Member 1 - biosynthesis ATP-Binding Cassette Transporters - biosynthesis ATP-Binding Cassette Transporters - genetics Biological and medical sciences Biological Transport Carcinoma, Ehrlich Tumor - drug therapy Daunorubicin - metabolism DNA Topoisomerases, Type II - analysis drug resistance Drug Resistance, Multiple Drug Resistance, Neoplasm General aspects Immunoassay Medical sciences Mice mitoxantrone Mitoxantrone - metabolism Mitoxantrone - pharmacology multidrug resistance-associated protein Multidrug Resistance-Associated Proteins Pharmacology. Drug treatments Subcellular Fractions - metabolism topoisomerase II Tumor Cells, Cultured tumour cell lines
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