Melatonin treatment enhances the efficiency of mice immunization with Venezuelan equine encephalomyelitis virus TC-83
To determine whether treatment with melatonin (MLT) improves the efficiency of immunization against Venezuelan equine encephalomyelitis (VEE) virus, mice were vaccinated with TC-83 VEE virus and treated daily with MLT (1 or 5 mg/kg) starting 3 days before immunization, until 10 days after. IgM antib...
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| Veröffentlicht in: | Neurochemical research 2001-07, Vol.26 (7), p.767-770 |
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| creator | NEGRETTE, Beatriz BONILLA, Ernesto VALERO, Nereida PONS, Hector GARCIA TAMAYO, Jorge CHACIN-BONILLA, Leonor MEDINA-LEENDERTZ, Shirley ANEZ, Florencio |
| description | To determine whether treatment with melatonin (MLT) improves the efficiency of immunization against Venezuelan equine encephalomyelitis (VEE) virus, mice were vaccinated with TC-83 VEE virus and treated daily with MLT (1 or 5 mg/kg) starting 3 days before immunization, until 10 days after. IgM antibody titers were determined at days 7, 14, and 21 post-immunization. IL-10 levels were assayed at day 14 postvaccination. Treatment with MLT increased antibody titers 14 days after the immunization. IL-10 levels also increased with MLT treatment (1 and 5 mg/kg). Mice were challenged with live VEE virus at day 21 postimmunization, and viral titers were plaque assayed in chicken embryo fibroblasts 4 days after the infection. Following this challenge brain virus levels were significantly reduced. The results suggest that MLT treatment enhances the efficiency of mice immunization against VEE virus. |
| doi_str_mv | 10.1023/A:1011645400123 |
| format | Article |
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IgM antibody titers were determined at days 7, 14, and 21 post-immunization. IL-10 levels were assayed at day 14 postvaccination. Treatment with MLT increased antibody titers 14 days after the immunization. IL-10 levels also increased with MLT treatment (1 and 5 mg/kg). Mice were challenged with live VEE virus at day 21 postimmunization, and viral titers were plaque assayed in chicken embryo fibroblasts 4 days after the infection. Following this challenge brain virus levels were significantly reduced. The results suggest that MLT treatment enhances the efficiency of mice immunization against VEE virus.</description><identifier>ISSN: 0364-3190</identifier><identifier>EISSN: 1573-6903</identifier><identifier>DOI: 10.1023/A:1011645400123</identifier><identifier>PMID: 11565607</identifier><identifier>CODEN: NEREDZ</identifier><language>eng</language><publisher>New York, NY: Springer</publisher><subject>Adjuvants, Immunologic - pharmacology ; Animals ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antibodies, Viral - analysis ; Antiviral agents ; Biological and medical sciences ; Brain - virology ; Encephalitis Virus, Venezuelan Equine - immunology ; Encephalitis Virus, Venezuelan Equine - isolation & purification ; Encephalomyelitis, Venezuelan Equine - prevention & control ; Encephalomyelitis, Venezuelan Equine - virology ; Immunization ; Medical sciences ; Melatonin - pharmacology ; Mice ; Pharmacology. Drug treatments ; Venezuelan equine encephalitis virus ; Viral Vaccines - immunology</subject><ispartof>Neurochemical research, 2001-07, Vol.26 (7), p.767-770</ispartof><rights>2001 INIST-CNRS</rights><rights>Copyright Kluwer Academic Publishers Jul 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1104615$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11565607$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NEGRETTE, Beatriz</creatorcontrib><creatorcontrib>BONILLA, Ernesto</creatorcontrib><creatorcontrib>VALERO, Nereida</creatorcontrib><creatorcontrib>PONS, Hector</creatorcontrib><creatorcontrib>GARCIA TAMAYO, Jorge</creatorcontrib><creatorcontrib>CHACIN-BONILLA, Leonor</creatorcontrib><creatorcontrib>MEDINA-LEENDERTZ, Shirley</creatorcontrib><creatorcontrib>ANEZ, Florencio</creatorcontrib><title>Melatonin treatment enhances the efficiency of mice immunization with Venezuelan equine encephalomyelitis virus TC-83</title><title>Neurochemical research</title><addtitle>Neurochem Res</addtitle><description>To determine whether treatment with melatonin (MLT) improves the efficiency of immunization against Venezuelan equine encephalomyelitis (VEE) virus, mice were vaccinated with TC-83 VEE virus and treated daily with MLT (1 or 5 mg/kg) starting 3 days before immunization, until 10 days after. IgM antibody titers were determined at days 7, 14, and 21 post-immunization. IL-10 levels were assayed at day 14 postvaccination. Treatment with MLT increased antibody titers 14 days after the immunization. IL-10 levels also increased with MLT treatment (1 and 5 mg/kg). Mice were challenged with live VEE virus at day 21 postimmunization, and viral titers were plaque assayed in chicken embryo fibroblasts 4 days after the infection. Following this challenge brain virus levels were significantly reduced. The results suggest that MLT treatment enhances the efficiency of mice immunization against VEE virus.</description><subject>Adjuvants, Immunologic - pharmacology</subject><subject>Animals</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antibodies, Viral - analysis</subject><subject>Antiviral agents</subject><subject>Biological and medical sciences</subject><subject>Brain - virology</subject><subject>Encephalitis Virus, Venezuelan Equine - immunology</subject><subject>Encephalitis Virus, Venezuelan Equine - isolation & purification</subject><subject>Encephalomyelitis, Venezuelan Equine - prevention & control</subject><subject>Encephalomyelitis, Venezuelan Equine - virology</subject><subject>Immunization</subject><subject>Medical sciences</subject><subject>Melatonin - pharmacology</subject><subject>Mice</subject><subject>Pharmacology. 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Antiinfectious agents. Antiparasitic agents</topic><topic>Antibodies, Viral - analysis</topic><topic>Antiviral agents</topic><topic>Biological and medical sciences</topic><topic>Brain - virology</topic><topic>Encephalitis Virus, Venezuelan Equine - immunology</topic><topic>Encephalitis Virus, Venezuelan Equine - isolation & purification</topic><topic>Encephalomyelitis, Venezuelan Equine - prevention & control</topic><topic>Encephalomyelitis, Venezuelan Equine - virology</topic><topic>Immunization</topic><topic>Medical sciences</topic><topic>Melatonin - pharmacology</topic><topic>Mice</topic><topic>Pharmacology. 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IgM antibody titers were determined at days 7, 14, and 21 post-immunization. IL-10 levels were assayed at day 14 postvaccination. Treatment with MLT increased antibody titers 14 days after the immunization. IL-10 levels also increased with MLT treatment (1 and 5 mg/kg). Mice were challenged with live VEE virus at day 21 postimmunization, and viral titers were plaque assayed in chicken embryo fibroblasts 4 days after the infection. Following this challenge brain virus levels were significantly reduced. The results suggest that MLT treatment enhances the efficiency of mice immunization against VEE virus.</abstract><cop>New York, NY</cop><pub>Springer</pub><pmid>11565607</pmid><doi>10.1023/A:1011645400123</doi><tpages>4</tpages></addata></record> |
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| subjects | Adjuvants, Immunologic - pharmacology Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antibodies, Viral - analysis Antiviral agents Biological and medical sciences Brain - virology Encephalitis Virus, Venezuelan Equine - immunology Encephalitis Virus, Venezuelan Equine - isolation & purification Encephalomyelitis, Venezuelan Equine - prevention & control Encephalomyelitis, Venezuelan Equine - virology Immunization Medical sciences Melatonin - pharmacology Mice Pharmacology. Drug treatments Venezuelan equine encephalitis virus Viral Vaccines - immunology |
| title | Melatonin treatment enhances the efficiency of mice immunization with Venezuelan equine encephalomyelitis virus TC-83 |
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