Argosomes: A Potential Vehicle for the Spread of Morphogens through Epithelia
The formation of morphogen gradients is essential for tissue patterning. Morphogens are released from producing cells and spread through adjacent tissue; paradoxically, however, many morphogens, including Wingless, associate tightly with the cell membrane. Here, we describe a novel cell biological m...
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| Veröffentlicht in: | Cell 2001-09, Vol.106 (5), p.633-645 |
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| creator | Greco, Valentina Hannus, Michael Eaton, Suzanne |
| description | The formation of morphogen gradients is essential for tissue patterning. Morphogens are released from producing cells and spread through adjacent tissue; paradoxically, however, many morphogens, including Wingless, associate tightly with the cell membrane. Here, we describe a novel cell biological mechanism that disperses membrane fragments over large distances through the
Drosophila imaginal disc epithelium. We call these membrane exovesicles argosomes. Argosomes are derived from basolateral membranes and are produced by many different regions of the disc. They travel through adjacent tissue where they are found predominantly in endosomes. Wingless protein colocalizes with argosomes derived from Wingless-producing cells. The properties of argosomes are consistent with their being a vehicle for the spread of Wingless protein. |
| doi_str_mv | 10.1016/S0092-8674(01)00484-6 |
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Drosophila imaginal disc epithelium. We call these membrane exovesicles argosomes. Argosomes are derived from basolateral membranes and are produced by many different regions of the disc. They travel through adjacent tissue where they are found predominantly in endosomes. Wingless protein colocalizes with argosomes derived from Wingless-producing cells. The properties of argosomes are consistent with their being a vehicle for the spread of Wingless protein.</description><identifier>ISSN: 0092-8674</identifier><identifier>EISSN: 1097-4172</identifier><identifier>DOI: 10.1016/S0092-8674(01)00484-6</identifier><identifier>PMID: 11551510</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Biomarkers ; Cell Membrane Structures - physiology ; Cell Membrane Structures - ultrastructure ; Drosophila ; Drosophila melanogaster - growth & development ; Drosophila melanogaster - metabolism ; Drosophila Proteins ; Endosomes - metabolism ; Epithelium - metabolism ; Green Fluorescent Proteins ; Heparin Lyase - pharmacology ; Indicators and Reagents - metabolism ; Luminescent Proteins - metabolism ; Models, Biological ; Morphogenesis - physiology ; morphogens ; Proto-Oncogene Proteins - metabolism ; Transport Vesicles - physiology ; Transport Vesicles - ultrastructure ; Wnt1 Protein</subject><ispartof>Cell, 2001-09, Vol.106 (5), p.633-645</ispartof><rights>2001 Cell Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0092-8674(01)00484-6$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11551510$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Greco, Valentina</creatorcontrib><creatorcontrib>Hannus, Michael</creatorcontrib><creatorcontrib>Eaton, Suzanne</creatorcontrib><title>Argosomes: A Potential Vehicle for the Spread of Morphogens through Epithelia</title><title>Cell</title><addtitle>Cell</addtitle><description>The formation of morphogen gradients is essential for tissue patterning. Morphogens are released from producing cells and spread through adjacent tissue; paradoxically, however, many morphogens, including Wingless, associate tightly with the cell membrane. Here, we describe a novel cell biological mechanism that disperses membrane fragments over large distances through the
Drosophila imaginal disc epithelium. We call these membrane exovesicles argosomes. Argosomes are derived from basolateral membranes and are produced by many different regions of the disc. They travel through adjacent tissue where they are found predominantly in endosomes. Wingless protein colocalizes with argosomes derived from Wingless-producing cells. 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Drosophila imaginal disc epithelium. We call these membrane exovesicles argosomes. Argosomes are derived from basolateral membranes and are produced by many different regions of the disc. They travel through adjacent tissue where they are found predominantly in endosomes. Wingless protein colocalizes with argosomes derived from Wingless-producing cells. The properties of argosomes are consistent with their being a vehicle for the spread of Wingless protein.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>11551510</pmid><doi>10.1016/S0092-8674(01)00484-6</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Cell Press Free Archives; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biomarkers Cell Membrane Structures - physiology Cell Membrane Structures - ultrastructure Drosophila Drosophila melanogaster - growth & development Drosophila melanogaster - metabolism Drosophila Proteins Endosomes - metabolism Epithelium - metabolism Green Fluorescent Proteins Heparin Lyase - pharmacology Indicators and Reagents - metabolism Luminescent Proteins - metabolism Models, Biological Morphogenesis - physiology morphogens Proto-Oncogene Proteins - metabolism Transport Vesicles - physiology Transport Vesicles - ultrastructure Wnt1 Protein |
| title | Argosomes: A Potential Vehicle for the Spread of Morphogens through Epithelia |
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