Synthesis of Potential Antidipsotropic Isoflavones: Inhibitors of the Mitochondrial Monoamine Oxidase−Aldehyde Dehydrogenase Pathway

Recently we have shown that daidzin, the major active principle of an ancient herbal treatment for “alcohol addiction”, suppresses ethanol intake in alcohol-preferring laboratory animals. Further, we have identified the monoamine oxidase (MAO)−aldehyde dehydrogenase (ALDH-2) pathway of the mitochond...

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Veröffentlicht in:	Journal of medicinal chemistry 2001-09, Vol.44 (20), p.3320-3328
Hauptverfasser:	Gao, Guang-Yao, Li, Dian-Jun, Keung, Wing Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Deterrents - chemical synthesis Alcohol Deterrents - chemistry Alcohol Deterrents - pharmacology Alcoholism and acute alcohol poisoning Aldehyde Dehydrogenase - antagonists & inhibitors Aldehyde Dehydrogenase, Mitochondrial Animals Binding Sites Biological and medical sciences Cricetinae Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Flavonoids - chemical synthesis Flavonoids - chemistry Flavonoids - pharmacology In Vitro Techniques Isoflavones - chemistry Medical sciences Mitochondria - drug effects Mitochondria - enzymology Mitochondria, Liver - drug effects Mitochondria, Liver - enzymology Monoamine Oxidase Inhibitors - chemical synthesis Monoamine Oxidase Inhibitors - chemistry Monoamine Oxidase Inhibitors - pharmacology Structure-Activity Relationship Toxicology
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