CD84 functions as a homophilic adhesion molecule and enhances IFN-gamma secretion: adhesion is mediated by Ig-like domain 1

CD84 is a member of the CD2 subset of the Ig superfamily of cell surface molecules. Its cytoplasmic tail binds to Src homology 2 domain-containing protein 1A (signaling lymphocytic activation molecule-associated protein), a protein encoded by the X-linked lymphoproliferative disease gene. It is pref...

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Veröffentlicht in:	The Journal of immunology (1950) 2001-10, Vol.167 (7), p.3668-3676
Hauptverfasser:	Martin, M, Romero, X, de la Fuente, M A, Tovar, V, Zapater, N, Esplugues, E, Pizcueta, P, Bosch, J, Engel, P
Format:	Artikel
Sprache:	eng
Schlagworte:	adhesion molecules Animals Antibodies, Monoclonal - immunology Antigens, CD - chemistry Antigens, CD - immunology Antigens, CD - physiology Binding, Competitive CD84 antigen Cell Adhesion Cell Adhesion Molecules - chemistry Cell Adhesion Molecules - physiology Cells, Cultured Child Child, Preschool COS Cells g-Interferon Humans Immunoglobulins - chemistry Interferon-gamma - biosynthesis Lymphocyte Activation Membrane Glycoproteins Mice Protein Structure, Tertiary Signaling Lymphocytic Activation Molecule Family T-Lymphocytes - immunology Thymus Gland - immunology Tumor Cells, Cultured
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