The influence of nitric oxide on in vivo human skeletal muscle properties
We have investigated the action of exogenous nitric oxide (NO) on the strength and contractile properties of human skeletal muscle working in vivo. Maximum isometric voluntary contraction force (MVC) of the quadriceps was measured and superimposed electrical stimulation was used to estimate the leve...
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| Veröffentlicht in: | Acta physiologica Scandinavica 2000-06, Vol.169 (2), p.141-148 |
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| description | We have investigated the action of exogenous nitric oxide (NO) on the strength and contractile properties of human skeletal muscle working in vivo. Maximum isometric voluntary contraction force (MVC) of the quadriceps was measured and superimposed electrical stimulation was used to estimate the level of activation and ‘true maximum force’ (TMF). Force–frequency relationships were determined to assess changes in contractile properties of the muscle. Subjects in the experimental group (E, n=10) were measured before and during two separate periods of treatment with different doses of glyceryl trinitrate, a NO donor, delivering 100 (GTN100) or 200 (GTN200) μg h–1 as a trans‐dermal patch. A control group (C, n=6) was measured during two similar periods whilst taking an oral placebo. There was a significant increase in strength with GTN200 (MVC: +5.15%; TMF: +3.87%). There was no change in the strength of group C. There was a trend towards reduced forces at submaximal frequencies with GTN administration but the most notable change was a decline in twitch force (approximately 12%, P |
| doi_str_mv | 10.1046/j.1365-201x.2000.00725.x |
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P ; MAAS, H ; JONES, D. A</creator><creatorcontrib>FOLLAND, J. P ; MAAS, H ; JONES, D. A</creatorcontrib><description>We have investigated the action of exogenous nitric oxide (NO) on the strength and contractile properties of human skeletal muscle working in vivo. Maximum isometric voluntary contraction force (MVC) of the quadriceps was measured and superimposed electrical stimulation was used to estimate the level of activation and ‘true maximum force’ (TMF). Force–frequency relationships were determined to assess changes in contractile properties of the muscle. Subjects in the experimental group (E, n=10) were measured before and during two separate periods of treatment with different doses of glyceryl trinitrate, a NO donor, delivering 100 (GTN100) or 200 (GTN200) μg h–1 as a trans‐dermal patch. A control group (C, n=6) was measured during two similar periods whilst taking an oral placebo. There was a significant increase in strength with GTN200 (MVC: +5.15%; TMF: +3.87%). There was no change in the strength of group C. There was a trend towards reduced forces at submaximal frequencies with GTN administration but the most notable change was a decline in twitch force (approximately 12%, P < 0.05) with GTN100 treatment and this remained depressed throughout the study. No changes were seen in the contractile properties of the control group C. The present results show that GTN treatment increased maximum voluntary strength but decreased twitch tension. The time course and dose–response characteristics indicate that these are two separate actions of NO on human muscle working in vivo.</description><identifier>ISSN: 0001-6772</identifier><identifier>EISSN: 1365-201X</identifier><identifier>DOI: 10.1046/j.1365-201x.2000.00725.x</identifier><identifier>PMID: 10848644</identifier><identifier>CODEN: APSCAX</identifier><language>eng</language><publisher>Oxford UK: Blackwell Science Ltd</publisher><subject>Adult ; Antianginal agents. Coronary vasodilator agents ; Biological and medical sciences ; Cardiovascular system ; Electric Stimulation ; Female ; force–frequency relationship ; Fundamental and applied biological sciences. Psychology ; glyceryl trinitrate (GTN) ; Humans ; Isometric Contraction - drug effects ; Male ; maximum voluntary contraction (MVC) ; Medical sciences ; Muscle, Skeletal - drug effects ; Muscle, Skeletal - physiology ; nitric oxide (NO) ; Nitric Oxide - metabolism ; Nitric Oxide Donors - administration & dosage ; Nitroglycerin - administration & dosage ; Pharmacology. Drug treatments ; skeletal muscle ; Striated muscle. Tendons ; Vasodilator Agents - administration & dosage ; Vertebrates: osteoarticular system, musculoskeletal system ; Volition - physiology</subject><ispartof>Acta physiologica Scandinavica, 2000-06, Vol.169 (2), p.141-148</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4445-8eeb043bec2e0548e9b916f81e2fca76ff8c633584e512f7f66c90bc59301fbc3</citedby><cites>FETCH-LOGICAL-c4445-8eeb043bec2e0548e9b916f81e2fca76ff8c633584e512f7f66c90bc59301fbc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-201x.2000.00725.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-201x.2000.00725.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1399611$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10848644$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FOLLAND, J. P</creatorcontrib><creatorcontrib>MAAS, H</creatorcontrib><creatorcontrib>JONES, D. A</creatorcontrib><title>The influence of nitric oxide on in vivo human skeletal muscle properties</title><title>Acta physiologica Scandinavica</title><addtitle>Acta Physiol Scand</addtitle><description>We have investigated the action of exogenous nitric oxide (NO) on the strength and contractile properties of human skeletal muscle working in vivo. Maximum isometric voluntary contraction force (MVC) of the quadriceps was measured and superimposed electrical stimulation was used to estimate the level of activation and ‘true maximum force’ (TMF). Force–frequency relationships were determined to assess changes in contractile properties of the muscle. Subjects in the experimental group (E, n=10) were measured before and during two separate periods of treatment with different doses of glyceryl trinitrate, a NO donor, delivering 100 (GTN100) or 200 (GTN200) μg h–1 as a trans‐dermal patch. A control group (C, n=6) was measured during two similar periods whilst taking an oral placebo. There was a significant increase in strength with GTN200 (MVC: +5.15%; TMF: +3.87%). There was no change in the strength of group C. There was a trend towards reduced forces at submaximal frequencies with GTN administration but the most notable change was a decline in twitch force (approximately 12%, P < 0.05) with GTN100 treatment and this remained depressed throughout the study. No changes were seen in the contractile properties of the control group C. The present results show that GTN treatment increased maximum voluntary strength but decreased twitch tension. The time course and dose–response characteristics indicate that these are two separate actions of NO on human muscle working in vivo.</description><subject>Adult</subject><subject>Antianginal agents. Coronary vasodilator agents</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular system</subject><subject>Electric Stimulation</subject><subject>Female</subject><subject>force–frequency relationship</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>glyceryl trinitrate (GTN)</subject><subject>Humans</subject><subject>Isometric Contraction - drug effects</subject><subject>Male</subject><subject>maximum voluntary contraction (MVC)</subject><subject>Medical sciences</subject><subject>Muscle, Skeletal - drug effects</subject><subject>Muscle, Skeletal - physiology</subject><subject>nitric oxide (NO)</subject><subject>Nitric Oxide - metabolism</subject><subject>Nitric Oxide Donors - administration & dosage</subject><subject>Nitroglycerin - administration & dosage</subject><subject>Pharmacology. Drug treatments</subject><subject>skeletal muscle</subject><subject>Striated muscle. Tendons</subject><subject>Vasodilator Agents - administration & dosage</subject><subject>Vertebrates: osteoarticular system, musculoskeletal system</subject><subject>Volition - physiology</subject><issn>0001-6772</issn><issn>1365-201X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE9P2zAYhy00RDu2rzD5MO2WzP_iOIcdqorBtEpwKBI3yzGvhTsnKXHTlRsS35RPgks6jSMn-9Xvef2TH4QwJTklQn5f5ZTLImOE7nJGCMkJKVmR747Q9F9w8wFNU0IzWZZsgj7GuEojV4ydoAklSigpxBT9Xt4B9q0LA7QWcOdw6ze9t7jb-ds0tyl8fnza-m2H74bGtDj-gQAbE3AzRBsAr_tuDf3GQ_yEjp0JET4fzlN0_fNsOb_IFpfnv-azRWaFEEWmAGoieA2WASmEgqquqHSKAnPWlNI5ZSXnhRJQUOZKJ6WtSG2LihPqastP0bfx3VR9P0Dc6MZHCyGYFroh6pLS9E0pEqhG0PZdjD04ve59Y_oHTYnei9Qrvfel9yL1XqR-Fal3afXLoWOoG7h9sziaS8DXA2CiNcH1prU-_ud4VUlKE_ZjxP76AA_v7tezq4tZuvEXCO2QHw</recordid><startdate>200006</startdate><enddate>200006</enddate><creator>FOLLAND, J. P</creator><creator>MAAS, H</creator><creator>JONES, D. A</creator><general>Blackwell Science Ltd</general><general>Blackwell Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200006</creationdate><title>The influence of nitric oxide on in vivo human skeletal muscle properties</title><author>FOLLAND, J. P ; MAAS, H ; JONES, D. A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4445-8eeb043bec2e0548e9b916f81e2fca76ff8c633584e512f7f66c90bc59301fbc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Antianginal agents. Coronary vasodilator agents</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular system</topic><topic>Electric Stimulation</topic><topic>Female</topic><topic>force–frequency relationship</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>glyceryl trinitrate (GTN)</topic><topic>Humans</topic><topic>Isometric Contraction - drug effects</topic><topic>Male</topic><topic>maximum voluntary contraction (MVC)</topic><topic>Medical sciences</topic><topic>Muscle, Skeletal - drug effects</topic><topic>Muscle, Skeletal - physiology</topic><topic>nitric oxide (NO)</topic><topic>Nitric Oxide - metabolism</topic><topic>Nitric Oxide Donors - administration & dosage</topic><topic>Nitroglycerin - administration & dosage</topic><topic>Pharmacology. Drug treatments</topic><topic>skeletal muscle</topic><topic>Striated muscle. Tendons</topic><topic>Vasodilator Agents - administration & dosage</topic><topic>Vertebrates: osteoarticular system, musculoskeletal system</topic><topic>Volition - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FOLLAND, J. P</creatorcontrib><creatorcontrib>MAAS, H</creatorcontrib><creatorcontrib>JONES, D. A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta physiologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FOLLAND, J. P</au><au>MAAS, H</au><au>JONES, D. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The influence of nitric oxide on in vivo human skeletal muscle properties</atitle><jtitle>Acta physiologica Scandinavica</jtitle><addtitle>Acta Physiol Scand</addtitle><date>2000-06</date><risdate>2000</risdate><volume>169</volume><issue>2</issue><spage>141</spage><epage>148</epage><pages>141-148</pages><issn>0001-6772</issn><eissn>1365-201X</eissn><coden>APSCAX</coden><abstract>We have investigated the action of exogenous nitric oxide (NO) on the strength and contractile properties of human skeletal muscle working in vivo. Maximum isometric voluntary contraction force (MVC) of the quadriceps was measured and superimposed electrical stimulation was used to estimate the level of activation and ‘true maximum force’ (TMF). Force–frequency relationships were determined to assess changes in contractile properties of the muscle. Subjects in the experimental group (E, n=10) were measured before and during two separate periods of treatment with different doses of glyceryl trinitrate, a NO donor, delivering 100 (GTN100) or 200 (GTN200) μg h–1 as a trans‐dermal patch. A control group (C, n=6) was measured during two similar periods whilst taking an oral placebo. There was a significant increase in strength with GTN200 (MVC: +5.15%; TMF: +3.87%). There was no change in the strength of group C. There was a trend towards reduced forces at submaximal frequencies with GTN administration but the most notable change was a decline in twitch force (approximately 12%, P < 0.05) with GTN100 treatment and this remained depressed throughout the study. No changes were seen in the contractile properties of the control group C. The present results show that GTN treatment increased maximum voluntary strength but decreased twitch tension. The time course and dose–response characteristics indicate that these are two separate actions of NO on human muscle working in vivo.</abstract><cop>Oxford UK</cop><pub>Blackwell Science Ltd</pub><pmid>10848644</pmid><doi>10.1046/j.1365-201x.2000.00725.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Antianginal agents. Coronary vasodilator agents Biological and medical sciences Cardiovascular system Electric Stimulation Female force–frequency relationship Fundamental and applied biological sciences. Psychology glyceryl trinitrate (GTN) Humans Isometric Contraction - drug effects Male maximum voluntary contraction (MVC) Medical sciences Muscle, Skeletal - drug effects Muscle, Skeletal - physiology nitric oxide (NO) Nitric Oxide - metabolism Nitric Oxide Donors - administration & dosage Nitroglycerin - administration & dosage Pharmacology. Drug treatments skeletal muscle Striated muscle. Tendons Vasodilator Agents - administration & dosage Vertebrates: osteoarticular system, musculoskeletal system Volition - physiology |
| title | The influence of nitric oxide on in vivo human skeletal muscle properties |
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