Sites of Aggrecan Cleavage by Recombinant Human Aggrecanase-1 (ADAMTS-4)

Aggrecan, the major proteoglycan of cartilage that provides its mechanical properties of compressibility and elasticity, is one of the first matrix components to undergo measurable loss in arthritic diseases. Two major sites of proteolytic cleavage have been identified within the interglobular domai...

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Veröffentlicht in:	The Journal of biological chemistry 2000-06, Vol.275 (24), p.18566-18573
Hauptverfasser:	Tortorella, Micky D., Pratta, Michael, Liu, Rui-Qin, Austin, Julian, Ross, O.Harold, Abbaszade, Ilgar, Burn, Tim, Arner, Elizabeth
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins ADAMTS-4 protein ADAMTS4 Protein aggrecan aggrecanase 1 Aggrecans Alanine - metabolism Amino Acid Sequence Electrophoresis, Polyacrylamide Gel Extracellular Matrix Proteins Glutamine - metabolism Humans Lectins, C-Type Metalloendopeptidases - metabolism Molecular Sequence Data Molecular Weight Procollagen N-Endopeptidase Proteoglycans - metabolism Substrate Specificity
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