The role of STAT proteins in growth hormone signaling
Growth hormone (GH) has long been known to be the body's primary regulator of body growth and a regulator of metabolism, yet the mechanisms by which GH regulates the transcription of specific genes required for these processes are just now being delineated. GH binding to its receptor recruits a...
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| Veröffentlicht in: | Oncogene 2000-05, Vol.19 (21), p.2585-2597 |
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| description | Growth hormone (GH) has long been known to be the body's primary regulator of body growth and a regulator of metabolism, yet the mechanisms by which GH regulates the transcription of specific genes required for these processes are just now being delineated. GH binding to its receptor recruits and activates the receptor-associated JAK2 that in turn phosphorylates tyrosines within itself and the GH receptor. These tyrosines form binding sites for a number of signaling proteins, including members of the family of signal transducers and activators of transcription (STAT). Among the known signaling molecules for GH, STAT proteins play a particularly prominent role in the regulation of gene transcription. This paper will review what is currently understood about which STAT proteins are regulated by GH, how they are regulated by GH, the GH-dependent genes they regulate, and discuss current theories about how GH-activated STAT signaling is regulated. Particular attention will be given to the novel role that STAT5 plays in sexually dimorphic gene expression in the liver as determined by the secretory pattern of GH and the role of STAT5 in body growth. Oncogene (2000). |
| doi_str_mv | 10.1038/sj.onc.1203526 |
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GH binding to its receptor recruits and activates the receptor-associated JAK2 that in turn phosphorylates tyrosines within itself and the GH receptor. These tyrosines form binding sites for a number of signaling proteins, including members of the family of signal transducers and activators of transcription (STAT). Among the known signaling molecules for GH, STAT proteins play a particularly prominent role in the regulation of gene transcription. This paper will review what is currently understood about which STAT proteins are regulated by GH, how they are regulated by GH, the GH-dependent genes they regulate, and discuss current theories about how GH-activated STAT signaling is regulated. Particular attention will be given to the novel role that STAT5 plays in sexually dimorphic gene expression in the liver as determined by the secretory pattern of GH and the role of STAT5 in body growth. Oncogene (2000).</description><identifier>ISSN: 0950-9232</identifier><identifier>EISSN: 1476-5594</identifier><identifier>DOI: 10.1038/sj.onc.1203526</identifier><identifier>PMID: 10851057</identifier><identifier>CODEN: ONCNES</identifier><language>eng</language><publisher>England: Nature Publishing Group</publisher><subject>Adaptor Proteins, Signal Transducing ; Animals ; Binding sites ; Carrier Proteins - metabolism ; Cell Nucleus - metabolism ; Cellular signal transduction ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Gene expression ; Gene Expression Regulation - genetics ; Gene regulation ; Genes ; Genetic aspects ; Genetic regulation ; Genetic transcription ; Growth Hormone - metabolism ; Growth hormones ; Human Growth Hormone - metabolism ; Humans ; Janus kinase 2 ; Kinases ; Liver ; Metabolism ; Milk Proteins ; Nuclear Proteins - genetics ; Phosphorylation ; Physiological aspects ; Physiology ; Proteins ; Receptors, Somatotropin - metabolism ; Serpins ; Sexual dimorphism ; Signal Transduction ; Somatotropin ; Stat5 protein ; STAT5 Transcription Factor ; Trans-Activators - genetics ; Trans-Activators - metabolism ; Transcription factors</subject><ispartof>Oncogene, 2000-05, Vol.19 (21), p.2585-2597</ispartof><rights>COPYRIGHT 2000 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group May 25, 2000</rights><rights>Macmillan Publishers Limited 2000.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c550t-8947c65d0034d7ded701f4cf2612c6749c397db68f62b28156ad2faf6c3e3dac3</citedby><cites>FETCH-LOGICAL-c550t-8947c65d0034d7ded701f4cf2612c6749c397db68f62b28156ad2faf6c3e3dac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10851057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Herrington, J</creatorcontrib><creatorcontrib>Smit, L S</creatorcontrib><creatorcontrib>Schwartz, J</creatorcontrib><creatorcontrib>Carter-Su, C</creatorcontrib><title>The role of STAT proteins in growth hormone signaling</title><title>Oncogene</title><addtitle>Oncogene</addtitle><description>Growth hormone (GH) has long been known to be the body's primary regulator of body growth and a regulator of metabolism, yet the mechanisms by which GH regulates the transcription of specific genes required for these processes are just now being delineated. GH binding to its receptor recruits and activates the receptor-associated JAK2 that in turn phosphorylates tyrosines within itself and the GH receptor. These tyrosines form binding sites for a number of signaling proteins, including members of the family of signal transducers and activators of transcription (STAT). Among the known signaling molecules for GH, STAT proteins play a particularly prominent role in the regulation of gene transcription. This paper will review what is currently understood about which STAT proteins are regulated by GH, how they are regulated by GH, the GH-dependent genes they regulate, and discuss current theories about how GH-activated STAT signaling is regulated. Particular attention will be given to the novel role that STAT5 plays in sexually dimorphic gene expression in the liver as determined by the secretory pattern of GH and the role of STAT5 in body growth. Oncogene (2000).</description><subject>Adaptor Proteins, Signal Transducing</subject><subject>Animals</subject><subject>Binding sites</subject><subject>Carrier Proteins - metabolism</subject><subject>Cell Nucleus - metabolism</subject><subject>Cellular signal transduction</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Gene expression</subject><subject>Gene Expression Regulation - genetics</subject><subject>Gene regulation</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic regulation</subject><subject>Genetic transcription</subject><subject>Growth Hormone - metabolism</subject><subject>Growth hormones</subject><subject>Human Growth Hormone - metabolism</subject><subject>Humans</subject><subject>Janus kinase 2</subject><subject>Kinases</subject><subject>Liver</subject><subject>Metabolism</subject><subject>Milk Proteins</subject><subject>Nuclear Proteins - genetics</subject><subject>Phosphorylation</subject><subject>Physiological aspects</subject><subject>Physiology</subject><subject>Proteins</subject><subject>Receptors, Somatotropin - metabolism</subject><subject>Serpins</subject><subject>Sexual dimorphism</subject><subject>Signal Transduction</subject><subject>Somatotropin</subject><subject>Stat5 protein</subject><subject>STAT5 Transcription Factor</subject><subject>Trans-Activators - genetics</subject><subject>Trans-Activators - metabolism</subject><subject>Transcription factors</subject><issn>0950-9232</issn><issn>1476-5594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkctrGzEQxkVIadyk1xzDkkJv647e0tGEviDQQ92zkPWwZXZXibSm9L-vTAwpJaXMYWD4zTePD6FrDEsMVH2o-2We3BIToJyIM7TATIqec83O0QI0h14TSi7Qm1r3ACA1kNfoAoPiGLhcIL7eha7kIXQ5dt_Xq3X3UPIc0lS7NHXbkn_Ou26Xy5in0NW0neyQpu0VehXtUMPbU75EPz59XN996e-_ff56t7rvHecw90oz6QT3AJR56YOXgCNzkQhMnJBMO6ql3wgVBdkQhbmwnkQbhaOBeuvoJXr_pNuWejyEOpsxVReGwU4hH6qRGCvgGv4LYsmZ1Fg28N1f4D4fSruqGiIYpkCFUo26_SdFJKVcMPUstbVDMGmKeS7WHeeaFQFgRznWqOULVAsfxuTaV2Nq9ZcaXMm1lhDNQ0mjLb8MBnP03NS9aZ6bk-et4ea07GEzBv8H_mQy_Q0MxqNd</recordid><startdate>20000525</startdate><enddate>20000525</enddate><creator>Herrington, J</creator><creator>Smit, L S</creator><creator>Schwartz, J</creator><creator>Carter-Su, C</creator><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20000525</creationdate><title>The role of STAT proteins in growth hormone signaling</title><author>Herrington, J ; Smit, L S ; Schwartz, J ; Carter-Su, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c550t-8947c65d0034d7ded701f4cf2612c6749c397db68f62b28156ad2faf6c3e3dac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adaptor Proteins, Signal Transducing</topic><topic>Animals</topic><topic>Binding sites</topic><topic>Carrier Proteins - 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Academic</collection><jtitle>Oncogene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Herrington, J</au><au>Smit, L S</au><au>Schwartz, J</au><au>Carter-Su, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of STAT proteins in growth hormone signaling</atitle><jtitle>Oncogene</jtitle><addtitle>Oncogene</addtitle><date>2000-05-25</date><risdate>2000</risdate><volume>19</volume><issue>21</issue><spage>2585</spage><epage>2597</epage><pages>2585-2597</pages><issn>0950-9232</issn><eissn>1476-5594</eissn><coden>ONCNES</coden><abstract>Growth hormone (GH) has long been known to be the body's primary regulator of body growth and a regulator of metabolism, yet the mechanisms by which GH regulates the transcription of specific genes required for these processes are just now being delineated. 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| source | MEDLINE; Nature Journals Online; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerLink Journals - AutoHoldings |
| subjects | Adaptor Proteins, Signal Transducing Animals Binding sites Carrier Proteins - metabolism Cell Nucleus - metabolism Cellular signal transduction DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene expression Gene Expression Regulation - genetics Gene regulation Genes Genetic aspects Genetic regulation Genetic transcription Growth Hormone - metabolism Growth hormones Human Growth Hormone - metabolism Humans Janus kinase 2 Kinases Liver Metabolism Milk Proteins Nuclear Proteins - genetics Phosphorylation Physiological aspects Physiology Proteins Receptors, Somatotropin - metabolism Serpins Sexual dimorphism Signal Transduction Somatotropin Stat5 protein STAT5 Transcription Factor Trans-Activators - genetics Trans-Activators - metabolism Transcription factors |
| title | The role of STAT proteins in growth hormone signaling |
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