Immunoreactivity for cadherins, HGF/SF, met, and erbB‐2 in pleural malignant mesotheliomas
Aims To assess the immunoreactivity of malignant mesotheliomas for N‐ and E‐cadherins, hepatocyte growth factor/scatter factor (HGF/SF) and the tyrosine kinase receptors, met and erbB‐2. Methods and results Pleural malignant mesotheliomas were stained using a standard indirect immunoperoxidase metho...
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| Veröffentlicht in: | Histopathology 2000-06, Vol.36 (6), p.522-528 |
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| creator | Thirkettle, I Harvey, P Hasleton, P S Ball, R Y Warn, R M |
| description | Aims
To assess the immunoreactivity of malignant mesotheliomas for N‐ and E‐cadherins, hepatocyte growth factor/scatter factor (HGF/SF) and the tyrosine kinase receptors, met and erbB‐2.
Methods and results
Pleural malignant mesotheliomas were stained using a standard indirect immunoperoxidase method applied to paraffin sections. Malignant mesotheliomas were immunoreactive for N‐cadherin (26/29; 90%), met (29/29; 100%) and erbB‐2 (28/29; 97%). Focal immunoreactivity was present for E‐cadherin in epithelioid or mixed tumours (14/25; 56%), and for HGF/SF (9/24; 38%).
Conclusions
Expression of N‐cadherin supports the diagnosis of malignant mesothelioma and use of appropriate antibodies would be a useful addition to a diagnostic antibody panel. Focal staining for E‐cadherin does not exclude mesothelioma. Signalling pathways mediated via met and erbB‐2 may play a role in the growth and spread of malignant mesotheliomas. |
| doi_str_mv | 10.1046/j.1365-2559.2000.00888.x |
| format | Article |
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To assess the immunoreactivity of malignant mesotheliomas for N‐ and E‐cadherins, hepatocyte growth factor/scatter factor (HGF/SF) and the tyrosine kinase receptors, met and erbB‐2.
Methods and results
Pleural malignant mesotheliomas were stained using a standard indirect immunoperoxidase method applied to paraffin sections. Malignant mesotheliomas were immunoreactive for N‐cadherin (26/29; 90%), met (29/29; 100%) and erbB‐2 (28/29; 97%). Focal immunoreactivity was present for E‐cadherin in epithelioid or mixed tumours (14/25; 56%), and for HGF/SF (9/24; 38%).
Conclusions
Expression of N‐cadherin supports the diagnosis of malignant mesothelioma and use of appropriate antibodies would be a useful addition to a diagnostic antibody panel. Focal staining for E‐cadherin does not exclude mesothelioma. Signalling pathways mediated via met and erbB‐2 may play a role in the growth and spread of malignant mesotheliomas.</description><identifier>ISSN: 0309-0167</identifier><identifier>EISSN: 1365-2559</identifier><identifier>DOI: 10.1046/j.1365-2559.2000.00888.x</identifier><identifier>PMID: 10849094</identifier><language>eng</language><publisher>Oxford, U.K. and Cambridge, USA: Blackwell Science Ltd</publisher><subject>Adenocarcinoma - metabolism ; Adenocarcinoma - pathology ; Biological and medical sciences ; Cadherins - analysis ; erbB‐2 ; E‐cadherin ; Hepatocyte Growth Factor - analysis ; hepatocyte growth factor/scatter factor ; Humans ; Immunohistochemistry ; Medical sciences ; mesothelioma ; Mesothelioma - metabolism ; Mesothelioma - pathology ; met ; Neoplasm Metastasis ; N‐cadherin ; Pleural Neoplasms - metabolism ; Pleural Neoplasms - pathology ; Pleurisy - metabolism ; Pleurisy - pathology ; Pneumology ; Proto-Oncogene Proteins c-met - analysis ; Receptor, ErbB-2 - analysis ; Tumors of the respiratory system and mediastinum</subject><ispartof>Histopathology, 2000-06, Vol.36 (6), p.522-528</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4598-5c88239967e059f888de76dafbbafee8964570d110d3b55ef6eae8e0d9e223f23</citedby><cites>FETCH-LOGICAL-c4598-5c88239967e059f888de76dafbbafee8964570d110d3b55ef6eae8e0d9e223f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2559.2000.00888.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1414952$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10849094$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thirkettle, I</creatorcontrib><creatorcontrib>Harvey, P</creatorcontrib><creatorcontrib>Hasleton, P S</creatorcontrib><creatorcontrib>Ball, R Y</creatorcontrib><creatorcontrib>Warn, R M</creatorcontrib><title>Immunoreactivity for cadherins, HGF/SF, met, and erbB‐2 in pleural malignant mesotheliomas</title><title>Histopathology</title><addtitle>Histopathology</addtitle><description>Aims
To assess the immunoreactivity of malignant mesotheliomas for N‐ and E‐cadherins, hepatocyte growth factor/scatter factor (HGF/SF) and the tyrosine kinase receptors, met and erbB‐2.
Methods and results
Pleural malignant mesotheliomas were stained using a standard indirect immunoperoxidase method applied to paraffin sections. Malignant mesotheliomas were immunoreactive for N‐cadherin (26/29; 90%), met (29/29; 100%) and erbB‐2 (28/29; 97%). Focal immunoreactivity was present for E‐cadherin in epithelioid or mixed tumours (14/25; 56%), and for HGF/SF (9/24; 38%).
Conclusions
Expression of N‐cadherin supports the diagnosis of malignant mesothelioma and use of appropriate antibodies would be a useful addition to a diagnostic antibody panel. Focal staining for E‐cadherin does not exclude mesothelioma. Signalling pathways mediated via met and erbB‐2 may play a role in the growth and spread of malignant mesotheliomas.</description><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - pathology</subject><subject>Biological and medical sciences</subject><subject>Cadherins - analysis</subject><subject>erbB‐2</subject><subject>E‐cadherin</subject><subject>Hepatocyte Growth Factor - analysis</subject><subject>hepatocyte growth factor/scatter factor</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Medical sciences</subject><subject>mesothelioma</subject><subject>Mesothelioma - metabolism</subject><subject>Mesothelioma - pathology</subject><subject>met</subject><subject>Neoplasm Metastasis</subject><subject>N‐cadherin</subject><subject>Pleural Neoplasms - metabolism</subject><subject>Pleural Neoplasms - pathology</subject><subject>Pleurisy - metabolism</subject><subject>Pleurisy - pathology</subject><subject>Pneumology</subject><subject>Proto-Oncogene Proteins c-met - analysis</subject><subject>Receptor, ErbB-2 - analysis</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0309-0167</issn><issn>1365-2559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM1u1DAQgC1ERbeFV0A-IE6bdOzEiS1xoVW3u1KlHgo3JMtJxtQrJ1nsBLq3PkKfkSchYVfAkdOMNN_8fYRQBimDvLjYpiwrRMKFUCkHgBRASpk-viCLP4WXZAEZqARYUZ6Ssxi3AKzMOH9FThnIXIHKF-TLpm3Hrg9o6sF9d8Oe2j7Q2jQPGFwXl3R9s7q4Xy1pi8OSmq6hGKrLn0_PnLqO7jyOwXjaGu--dqYbJiz2wwN617cmviYn1viIb47xnHxeXX-6Wie3dzebq4-3SZ0LJRNRS8kzpYoSQSg7fdJgWTTGVpWxiFIVuSihYQyarBICbYEGJUKjkPPM8uycvD_M3YX-24hx0K2LNXpvOuzHqEvGSskZm0B5AOvQxxjQ6l1wrQl7zUDPZvVWzwL1LFDPZvVvs_pxan173DFWLTb_NB5UTsC7I2BibbwNpqtd_MvlLFdivvXDAfvhPO7_e79eb-6nJPsFifyUfA</recordid><startdate>200006</startdate><enddate>200006</enddate><creator>Thirkettle, I</creator><creator>Harvey, P</creator><creator>Hasleton, P S</creator><creator>Ball, R Y</creator><creator>Warn, R M</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200006</creationdate><title>Immunoreactivity for cadherins, HGF/SF, met, and erbB‐2 in pleural malignant mesotheliomas</title><author>Thirkettle, I ; Harvey, P ; Hasleton, P S ; Ball, R Y ; Warn, R M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4598-5c88239967e059f888de76dafbbafee8964570d110d3b55ef6eae8e0d9e223f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - pathology</topic><topic>Biological and medical sciences</topic><topic>Cadherins - analysis</topic><topic>erbB‐2</topic><topic>E‐cadherin</topic><topic>Hepatocyte Growth Factor - analysis</topic><topic>hepatocyte growth factor/scatter factor</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Medical sciences</topic><topic>mesothelioma</topic><topic>Mesothelioma - metabolism</topic><topic>Mesothelioma - pathology</topic><topic>met</topic><topic>Neoplasm Metastasis</topic><topic>N‐cadherin</topic><topic>Pleural Neoplasms - metabolism</topic><topic>Pleural Neoplasms - pathology</topic><topic>Pleurisy - metabolism</topic><topic>Pleurisy - pathology</topic><topic>Pneumology</topic><topic>Proto-Oncogene Proteins c-met - analysis</topic><topic>Receptor, ErbB-2 - analysis</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thirkettle, I</creatorcontrib><creatorcontrib>Harvey, P</creatorcontrib><creatorcontrib>Hasleton, P S</creatorcontrib><creatorcontrib>Ball, R Y</creatorcontrib><creatorcontrib>Warn, R M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Histopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thirkettle, I</au><au>Harvey, P</au><au>Hasleton, P S</au><au>Ball, R Y</au><au>Warn, R M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunoreactivity for cadherins, HGF/SF, met, and erbB‐2 in pleural malignant mesotheliomas</atitle><jtitle>Histopathology</jtitle><addtitle>Histopathology</addtitle><date>2000-06</date><risdate>2000</risdate><volume>36</volume><issue>6</issue><spage>522</spage><epage>528</epage><pages>522-528</pages><issn>0309-0167</issn><eissn>1365-2559</eissn><abstract>Aims
To assess the immunoreactivity of malignant mesotheliomas for N‐ and E‐cadherins, hepatocyte growth factor/scatter factor (HGF/SF) and the tyrosine kinase receptors, met and erbB‐2.
Methods and results
Pleural malignant mesotheliomas were stained using a standard indirect immunoperoxidase method applied to paraffin sections. Malignant mesotheliomas were immunoreactive for N‐cadherin (26/29; 90%), met (29/29; 100%) and erbB‐2 (28/29; 97%). Focal immunoreactivity was present for E‐cadherin in epithelioid or mixed tumours (14/25; 56%), and for HGF/SF (9/24; 38%).
Conclusions
Expression of N‐cadherin supports the diagnosis of malignant mesothelioma and use of appropriate antibodies would be a useful addition to a diagnostic antibody panel. Focal staining for E‐cadherin does not exclude mesothelioma. Signalling pathways mediated via met and erbB‐2 may play a role in the growth and spread of malignant mesotheliomas.</abstract><cop>Oxford, U.K. and Cambridge, USA</cop><pub>Blackwell Science Ltd</pub><pmid>10849094</pmid><doi>10.1046/j.1365-2559.2000.00888.x</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adenocarcinoma - metabolism Adenocarcinoma - pathology Biological and medical sciences Cadherins - analysis erbB‐2 E‐cadherin Hepatocyte Growth Factor - analysis hepatocyte growth factor/scatter factor Humans Immunohistochemistry Medical sciences mesothelioma Mesothelioma - metabolism Mesothelioma - pathology met Neoplasm Metastasis N‐cadherin Pleural Neoplasms - metabolism Pleural Neoplasms - pathology Pleurisy - metabolism Pleurisy - pathology Pneumology Proto-Oncogene Proteins c-met - analysis Receptor, ErbB-2 - analysis Tumors of the respiratory system and mediastinum |
| title | Immunoreactivity for cadherins, HGF/SF, met, and erbB‐2 in pleural malignant mesotheliomas |
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