Cardiomyocyte-transistor-hybrids for sensor application
An extracellular recording system has been designed for the detection of electrical cell signals using p-channel or n-channel field-effect transistor (FET) arrays with non-metallized gates. Signals from rat heart muscle cell were recorded by these devices and the results described on the basis of an...
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| Veröffentlicht in: | Biosensors & bioelectronics 2001-09, Vol.16 (7), p.565-570 |
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| container_title | Biosensors & bioelectronics |
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| creator | Ingebrandt, Sven Yeung, Chi-Kong Krause, Michael Offenhäusser, Andreas |
| description | An extracellular recording system has been designed for the detection of electrical cell signals using p-channel or n-channel field-effect transistor (FET) arrays with non-metallized gates. Signals from rat heart muscle cell were recorded by these devices and the results described on the basis of an equivalent circuit. This technique is sensitive enough to detect minute changes of the extracellular membrane voltage and has potential applications in drug screening. We show that known cardiac stimulants (isoproterenol, norepinephrine) and relaxants (verapamil, carbamylcholine) have characteristic effects on the heart cells in terms of the changes of beat frequencies in the absence or presence of corresponding agents. |
| doi_str_mv | 10.1016/S0956-5663(01)00170-1 |
| format | Article |
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Signals from rat heart muscle cell were recorded by these devices and the results described on the basis of an equivalent circuit. This technique is sensitive enough to detect minute changes of the extracellular membrane voltage and has potential applications in drug screening. 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| ispartof | Biosensors & bioelectronics, 2001-09, Vol.16 (7), p.565-570 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Action Potentials - drug effects Animals Biosensing Techniques - instrumentation Cardiovascular Agents - pharmacology Cells, Cultured Dissociated cardiac myocytes Drug Evaluation, Preclinical Extracellular recording Field effect transistors Heart - drug effects Myocardium - cytology Myocardium - metabolism Pharmacological biosensor Rats Transistors, Electronic |
| title | Cardiomyocyte-transistor-hybrids for sensor application |
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