Phenotypic Modulation by Fibronectin Enhances the Angiotensin II–Generating System in Cultured Vascular Smooth Muscle Cells

We previously demonstrated that homogeneous cultures of vascular smooth muscle cells (VSMCs) from spontaneously hypertensive rats produce angiotensin II (Ang II) in response to increases in the levels of angiotensinogen, cathepsin D, and angiotensin-converting enzyme (ACE). The change of VSMCs from...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2000-06, Vol.20 (6), p.1500-1505
Hauptverfasser:	Hu, Wen-Yang, Fukuda, Noboru, Satoh, Chikara, Jian, Teng, Kubo, Atsushi, Nakayama, Mari, Kishioka, Hirobumi, Kanmatsuse, Katsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - biosynthesis Angiotensin II - genetics Animals Aorta Blotting, Western Cathepsin D - genetics Cell Division - drug effects Cells, Cultured Fibroblast Growth Factor 2 - genetics Fibronectins - pharmacology Gene Expression - drug effects Kinetics Male Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Peptide Fragments - pharmacology Peptidyl-Dipeptidase A - genetics Phenotype Rats Rats, Inbred WKY Reverse Transcriptase Polymerase Chain Reaction Transforming Growth Factor beta - genetics
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