Cytokine Release and Serum Lipoprotein (a) Alterations During Hemodialysis
: It has been reported recently that a number of cytokines, mainly tumor necrosis factor α (TNFα), interleukin (IL)‐1β, and IL‐6, can alter lipid metabolism and produce hyperlipidemia. Studies in hemodialysis (HD) patients have demonstrated increased production of these cytokines during HD. In order...
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| Veröffentlicht in: | Artificial organs 2000-05, Vol.24 (5), p.329-333 |
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| creator | Tzanatos, Helen A. Agroyannis, Basil Chondros, Costas Kapetanaki, Antigoni Fourtounas, Costas Soubassi, Lygeri Kopelias, Ioannis |
| description | : It has been reported recently that a number of cytokines, mainly tumor necrosis factor α (TNFα), interleukin (IL)‐1β, and IL‐6, can alter lipid metabolism and produce hyperlipidemia. Studies in hemodialysis (HD) patients have demonstrated increased production of these cytokines during HD. In order to investigate any possible relationship between changes of cytokines and lipid concentrations during HD in the serum of 25 uremic patients on chronic HD using modified cellulose membranes, TNFα, IL‐1β, IL‐6, total cholesterol (TC), triglycerides (TG), high‐density lipoprotein cholesterol (HDL‐C), low‐density lipoprotein cholesterol (LDL‐C), lipoprotein a (Lp[a]), and total proteins were measured immediately before (pre‐HD) and after HD (post‐HD), in one session. The post‐HD values were corrected according to the hemoconcentration based on the changes in serum total proteins. Serum TNFα and IL‐1β levels were significantly increased from 38.24 ± 17.85 pg/ml and 2.60 ± 3.64 pg/ml pre‐HD to 48.86 ± 25.21 and 3.49 ± 4.08 pg/ml post‐HD, p < 0.001 and p < 0.05 respectively. Also Lp(a) levels presented a statistically significant increase post‐HD and were almost doubled (pre‐HD: 15.41 mg/dl, to post‐HD: 27.39 mg/dl, p < 0.05). Serum IL‐6 as well as serum TC, TG, HDL‐C, and LDL‐C did not show any statistically significant alterations during HD. A significant positive correlation was detected between TNFα and Lp(a) values post‐HD (r: 0.413, p: 0.04), but not between pre‐HD values. No further relationship between serum cytokines and the other estimated lipid parameters was observed, either between pre‐ or post‐HD values. Our results indicate that release of TNFα and IL‐1β during HD have no effect on serum lipids concentration, except on Lp(a). It seems that the acute rise of this lipoprotein during hemodialysis may be related with the TNFα overproduction. |
| doi_str_mv | 10.1046/j.1525-1594.2000.06483.x |
| format | Article |
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Studies in hemodialysis (HD) patients have demonstrated increased production of these cytokines during HD. In order to investigate any possible relationship between changes of cytokines and lipid concentrations during HD in the serum of 25 uremic patients on chronic HD using modified cellulose membranes, TNFα, IL‐1β, IL‐6, total cholesterol (TC), triglycerides (TG), high‐density lipoprotein cholesterol (HDL‐C), low‐density lipoprotein cholesterol (LDL‐C), lipoprotein a (Lp[a]), and total proteins were measured immediately before (pre‐HD) and after HD (post‐HD), in one session. The post‐HD values were corrected according to the hemoconcentration based on the changes in serum total proteins. Serum TNFα and IL‐1β levels were significantly increased from 38.24 ± 17.85 pg/ml and 2.60 ± 3.64 pg/ml pre‐HD to 48.86 ± 25.21 and 3.49 ± 4.08 pg/ml post‐HD, p < 0.001 and p < 0.05 respectively. Also Lp(a) levels presented a statistically significant increase post‐HD and were almost doubled (pre‐HD: 15.41 mg/dl, to post‐HD: 27.39 mg/dl, p < 0.05). Serum IL‐6 as well as serum TC, TG, HDL‐C, and LDL‐C did not show any statistically significant alterations during HD. A significant positive correlation was detected between TNFα and Lp(a) values post‐HD (r: 0.413, p: 0.04), but not between pre‐HD values. No further relationship between serum cytokines and the other estimated lipid parameters was observed, either between pre‐ or post‐HD values. Our results indicate that release of TNFα and IL‐1β during HD have no effect on serum lipids concentration, except on Lp(a). It seems that the acute rise of this lipoprotein during hemodialysis may be related with the TNFα overproduction.</description><identifier>ISSN: 0160-564X</identifier><identifier>EISSN: 1525-1594</identifier><identifier>DOI: 10.1046/j.1525-1594.2000.06483.x</identifier><identifier>PMID: 10848673</identifier><language>eng</language><publisher>Boston, MA, USA: Blackwell Science Inc</publisher><subject>Blood Proteins - analysis ; Cellulose ; Cholesterol - blood ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Cytokines ; Female ; Follow-Up Studies ; Hemodialysis ; Humans ; Interleukin-1 - blood ; Interleukin-1 - metabolism ; Interleukin-1β ; Interleukin-6 ; Interleukin-6 - blood ; Interleukin-6 - metabolism ; Lipoprotein (a) ; Lipoprotein(a) - blood ; Male ; Membranes, Artificial ; Middle Aged ; Renal Dialysis - instrumentation ; Statistics as Topic ; Triglycerides - blood ; Tumor necrosis factor ; Tumor Necrosis Factor-alpha - analysis ; Tumor Necrosis Factor-alpha - metabolism ; Uremia - therapy</subject><ispartof>Artificial organs, 2000-05, Vol.24 (5), p.329-333</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4033-6a62bd5f5159605aa337692da408b48459cc27dd57249b8f42eebef820454e9c3</citedby><cites>FETCH-LOGICAL-c4033-6a62bd5f5159605aa337692da408b48459cc27dd57249b8f42eebef820454e9c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1525-1594.2000.06483.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1525-1594.2000.06483.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10848673$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tzanatos, Helen A.</creatorcontrib><creatorcontrib>Agroyannis, Basil</creatorcontrib><creatorcontrib>Chondros, Costas</creatorcontrib><creatorcontrib>Kapetanaki, Antigoni</creatorcontrib><creatorcontrib>Fourtounas, Costas</creatorcontrib><creatorcontrib>Soubassi, Lygeri</creatorcontrib><creatorcontrib>Kopelias, Ioannis</creatorcontrib><title>Cytokine Release and Serum Lipoprotein (a) Alterations During Hemodialysis</title><title>Artificial organs</title><addtitle>Artificial Organs</addtitle><description>: It has been reported recently that a number of cytokines, mainly tumor necrosis factor α (TNFα), interleukin (IL)‐1β, and IL‐6, can alter lipid metabolism and produce hyperlipidemia. Studies in hemodialysis (HD) patients have demonstrated increased production of these cytokines during HD. In order to investigate any possible relationship between changes of cytokines and lipid concentrations during HD in the serum of 25 uremic patients on chronic HD using modified cellulose membranes, TNFα, IL‐1β, IL‐6, total cholesterol (TC), triglycerides (TG), high‐density lipoprotein cholesterol (HDL‐C), low‐density lipoprotein cholesterol (LDL‐C), lipoprotein a (Lp[a]), and total proteins were measured immediately before (pre‐HD) and after HD (post‐HD), in one session. The post‐HD values were corrected according to the hemoconcentration based on the changes in serum total proteins. Serum TNFα and IL‐1β levels were significantly increased from 38.24 ± 17.85 pg/ml and 2.60 ± 3.64 pg/ml pre‐HD to 48.86 ± 25.21 and 3.49 ± 4.08 pg/ml post‐HD, p < 0.001 and p < 0.05 respectively. Also Lp(a) levels presented a statistically significant increase post‐HD and were almost doubled (pre‐HD: 15.41 mg/dl, to post‐HD: 27.39 mg/dl, p < 0.05). Serum IL‐6 as well as serum TC, TG, HDL‐C, and LDL‐C did not show any statistically significant alterations during HD. A significant positive correlation was detected between TNFα and Lp(a) values post‐HD (r: 0.413, p: 0.04), but not between pre‐HD values. No further relationship between serum cytokines and the other estimated lipid parameters was observed, either between pre‐ or post‐HD values. Our results indicate that release of TNFα and IL‐1β during HD have no effect on serum lipids concentration, except on Lp(a). It seems that the acute rise of this lipoprotein during hemodialysis may be related with the TNFα overproduction.</description><subject>Blood Proteins - analysis</subject><subject>Cellulose</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Cytokines</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Hemodialysis</subject><subject>Humans</subject><subject>Interleukin-1 - blood</subject><subject>Interleukin-1 - metabolism</subject><subject>Interleukin-1β</subject><subject>Interleukin-6</subject><subject>Interleukin-6 - blood</subject><subject>Interleukin-6 - metabolism</subject><subject>Lipoprotein (a)</subject><subject>Lipoprotein(a) - blood</subject><subject>Male</subject><subject>Membranes, Artificial</subject><subject>Middle Aged</subject><subject>Renal Dialysis - instrumentation</subject><subject>Statistics as Topic</subject><subject>Triglycerides - blood</subject><subject>Tumor necrosis factor</subject><subject>Tumor Necrosis Factor-alpha - analysis</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>Uremia - therapy</subject><issn>0160-564X</issn><issn>1525-1594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtq20AUhoeS0jhJXyFoFZKF1BnNRaNFFkZJ7VJjQ9KS7oaRdBTG1sWZkai9C_RN-ySVKmOyzGoOzPf_5_Ah5BEcEMzEl3VAeMh9wmMWhBjjAAsmabD7gCbHjxM0wURgnwv26xSdObfuwYhh8QmdEiyZFBGdoEWyb5uNqcF7gBK0A0_XufcItqu8hdk2W9u0YGrvWt9407IFq1vT1M6766ypn_--_plD1eRGl3tn3AX6WOjSwefDe45-fr3_kcz9xWr2LZku_IxhSn2hRZjmvOD9mQJzrSmNRBzmmmGZMsl4nGVhlOc8ClmcyoKFACkUMsSMM4gzeo6uxt7-upcOXKsq4zIoS11D0zkVERJxSWUPyhHMbOOchUJtram03SuC1WBSrdUgTA3C1GBS_Tepdn308rCjSyvI3wRHdT1wOwK_TQn7dxer6ephmPq8P-aNa2F3zGu7UX19xNXTcqaSmCfx8vuTEvQfftuRRw</recordid><startdate>200005</startdate><enddate>200005</enddate><creator>Tzanatos, Helen A.</creator><creator>Agroyannis, Basil</creator><creator>Chondros, Costas</creator><creator>Kapetanaki, Antigoni</creator><creator>Fourtounas, Costas</creator><creator>Soubassi, Lygeri</creator><creator>Kopelias, Ioannis</creator><general>Blackwell Science Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200005</creationdate><title>Cytokine Release and Serum Lipoprotein (a) Alterations During Hemodialysis</title><author>Tzanatos, Helen A. ; Agroyannis, Basil ; Chondros, Costas ; Kapetanaki, Antigoni ; Fourtounas, Costas ; Soubassi, Lygeri ; Kopelias, Ioannis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4033-6a62bd5f5159605aa337692da408b48459cc27dd57249b8f42eebef820454e9c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Blood Proteins - analysis</topic><topic>Cellulose</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Cytokines</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Hemodialysis</topic><topic>Humans</topic><topic>Interleukin-1 - blood</topic><topic>Interleukin-1 - metabolism</topic><topic>Interleukin-1β</topic><topic>Interleukin-6</topic><topic>Interleukin-6 - blood</topic><topic>Interleukin-6 - metabolism</topic><topic>Lipoprotein (a)</topic><topic>Lipoprotein(a) - blood</topic><topic>Male</topic><topic>Membranes, Artificial</topic><topic>Middle Aged</topic><topic>Renal Dialysis - instrumentation</topic><topic>Statistics as Topic</topic><topic>Triglycerides - blood</topic><topic>Tumor necrosis factor</topic><topic>Tumor Necrosis Factor-alpha - analysis</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>Uremia - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tzanatos, Helen A.</creatorcontrib><creatorcontrib>Agroyannis, Basil</creatorcontrib><creatorcontrib>Chondros, Costas</creatorcontrib><creatorcontrib>Kapetanaki, Antigoni</creatorcontrib><creatorcontrib>Fourtounas, Costas</creatorcontrib><creatorcontrib>Soubassi, Lygeri</creatorcontrib><creatorcontrib>Kopelias, Ioannis</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Artificial organs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tzanatos, Helen A.</au><au>Agroyannis, Basil</au><au>Chondros, Costas</au><au>Kapetanaki, Antigoni</au><au>Fourtounas, Costas</au><au>Soubassi, Lygeri</au><au>Kopelias, Ioannis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytokine Release and Serum Lipoprotein (a) Alterations During Hemodialysis</atitle><jtitle>Artificial organs</jtitle><addtitle>Artificial Organs</addtitle><date>2000-05</date><risdate>2000</risdate><volume>24</volume><issue>5</issue><spage>329</spage><epage>333</epage><pages>329-333</pages><issn>0160-564X</issn><eissn>1525-1594</eissn><abstract>: It has been reported recently that a number of cytokines, mainly tumor necrosis factor α (TNFα), interleukin (IL)‐1β, and IL‐6, can alter lipid metabolism and produce hyperlipidemia. Studies in hemodialysis (HD) patients have demonstrated increased production of these cytokines during HD. In order to investigate any possible relationship between changes of cytokines and lipid concentrations during HD in the serum of 25 uremic patients on chronic HD using modified cellulose membranes, TNFα, IL‐1β, IL‐6, total cholesterol (TC), triglycerides (TG), high‐density lipoprotein cholesterol (HDL‐C), low‐density lipoprotein cholesterol (LDL‐C), lipoprotein a (Lp[a]), and total proteins were measured immediately before (pre‐HD) and after HD (post‐HD), in one session. The post‐HD values were corrected according to the hemoconcentration based on the changes in serum total proteins. Serum TNFα and IL‐1β levels were significantly increased from 38.24 ± 17.85 pg/ml and 2.60 ± 3.64 pg/ml pre‐HD to 48.86 ± 25.21 and 3.49 ± 4.08 pg/ml post‐HD, p < 0.001 and p < 0.05 respectively. Also Lp(a) levels presented a statistically significant increase post‐HD and were almost doubled (pre‐HD: 15.41 mg/dl, to post‐HD: 27.39 mg/dl, p < 0.05). Serum IL‐6 as well as serum TC, TG, HDL‐C, and LDL‐C did not show any statistically significant alterations during HD. A significant positive correlation was detected between TNFα and Lp(a) values post‐HD (r: 0.413, p: 0.04), but not between pre‐HD values. No further relationship between serum cytokines and the other estimated lipid parameters was observed, either between pre‐ or post‐HD values. Our results indicate that release of TNFα and IL‐1β during HD have no effect on serum lipids concentration, except on Lp(a). It seems that the acute rise of this lipoprotein during hemodialysis may be related with the TNFα overproduction.</abstract><cop>Boston, MA, USA</cop><pub>Blackwell Science Inc</pub><pmid>10848673</pmid><doi>10.1046/j.1525-1594.2000.06483.x</doi><tpages>5</tpages></addata></record> |
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| subjects | Blood Proteins - analysis Cellulose Cholesterol - blood Cholesterol, HDL - blood Cholesterol, LDL - blood Cytokines Female Follow-Up Studies Hemodialysis Humans Interleukin-1 - blood Interleukin-1 - metabolism Interleukin-1β Interleukin-6 Interleukin-6 - blood Interleukin-6 - metabolism Lipoprotein (a) Lipoprotein(a) - blood Male Membranes, Artificial Middle Aged Renal Dialysis - instrumentation Statistics as Topic Triglycerides - blood Tumor necrosis factor Tumor Necrosis Factor-alpha - analysis Tumor Necrosis Factor-alpha - metabolism Uremia - therapy |
| title | Cytokine Release and Serum Lipoprotein (a) Alterations During Hemodialysis |
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