Ileal carcinoid tumor complicating carcinoid heart disease and secondary retroperitoneal fibrosis
A 70‐year‐old man with metastatic liver tumors showed carcinoid syndrome with clinical symptoms of facial flushing, palpitation, dyspnea, and an itching sensation. Regurgitation of the tricuspid and aortic valves was observed by echocardiography. An elevated serum level of serotonin and a high urine...
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| Veröffentlicht in: | Pathology international 2000-05, Vol.50 (5), p.404-411 |
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| creator | Sakai, Daisuke Murakami, Masato Kawazoe, Kazuya Tsutsumi, Yutaka |
| description | A 70‐year‐old man with metastatic liver tumors showed carcinoid syndrome with clinical symptoms of facial flushing, palpitation, dyspnea, and an itching sensation. Regurgitation of the tricuspid and aortic valves was observed by echocardiography. An elevated serum level of serotonin and a high urine excretion of serotonin metabolites were confirmed. Autopsy confirmed a serotonin‐immunoreactive 1 cm ileal carcinoid tumor with metastasis to the liver, bone and peritoneum. The tumor cells were argyrophilic but not argentaffin, and showed erythrophagocytosis in the primary lesion. All the four heart valves and bilateral atrial endocardium showed fibromyxoid thickening, indicating the association of carcinoid heart disease. Desmoplastic reaction with deposition of sulfated acid mucopolysaccharides was also observed in the retroperitoneal space (secondary retroperitoneal fibrosis). Stenosis of the bilateral ureters and inferior mesenteric artery provoked hydronephrosis and lethal ischemic necrosis of the left‐sided colon, respectively. Rarity of functioning ileal carcinoid tumor and pathogenesis of systemic fibroplasia are discussed. |
| doi_str_mv | 10.1046/j.1440-1827.2000.01053.x |
| format | Article |
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Regurgitation of the tricuspid and aortic valves was observed by echocardiography. An elevated serum level of serotonin and a high urine excretion of serotonin metabolites were confirmed. Autopsy confirmed a serotonin‐immunoreactive 1 cm ileal carcinoid tumor with metastasis to the liver, bone and peritoneum. The tumor cells were argyrophilic but not argentaffin, and showed erythrophagocytosis in the primary lesion. All the four heart valves and bilateral atrial endocardium showed fibromyxoid thickening, indicating the association of carcinoid heart disease. Desmoplastic reaction with deposition of sulfated acid mucopolysaccharides was also observed in the retroperitoneal space (secondary retroperitoneal fibrosis). Stenosis of the bilateral ureters and inferior mesenteric artery provoked hydronephrosis and lethal ischemic necrosis of the left‐sided colon, respectively. Rarity of functioning ileal carcinoid tumor and pathogenesis of systemic fibroplasia are discussed.</description><identifier>ISSN: 1320-5463</identifier><identifier>EISSN: 1440-1827</identifier><identifier>DOI: 10.1046/j.1440-1827.2000.01053.x</identifier><identifier>PMID: 10849330</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Science Pty</publisher><subject>Aged ; Bone Neoplasms - metabolism ; Bone Neoplasms - secondary ; carcinoid heart ; Carcinoid Heart Disease - etiology ; Carcinoid Heart Disease - pathology ; carcinoid syndrome ; Carcinoid Tumor - complications ; Carcinoid Tumor - metabolism ; Carcinoid Tumor - secondary ; erythrophagocytosis ; Humans ; ileal carcinoid ; Ileal Neoplasms - complications ; Ileal Neoplasms - metabolism ; Ileal Neoplasms - pathology ; Immunoenzyme Techniques ; Liver Neoplasms - metabolism ; Liver Neoplasms - secondary ; Male ; Peritoneal Neoplasms - metabolism ; Peritoneal Neoplasms - secondary ; Retroperitoneal Fibrosis - etiology ; Retroperitoneal Fibrosis - pathology ; secondary retroperitoneal fibrosis ; serotonin ; Serotonin - metabolism</subject><ispartof>Pathology international, 2000-05, Vol.50 (5), p.404-411</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5353-ca9a08e5dbf694c0a25029e06cf14ce6e3896bbf3144f3af2c4549c01c8a3d7c3</citedby><cites>FETCH-LOGICAL-c5353-ca9a08e5dbf694c0a25029e06cf14ce6e3896bbf3144f3af2c4549c01c8a3d7c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1440-1827.2000.01053.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1440-1827.2000.01053.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10849330$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sakai, Daisuke</creatorcontrib><creatorcontrib>Murakami, Masato</creatorcontrib><creatorcontrib>Kawazoe, Kazuya</creatorcontrib><creatorcontrib>Tsutsumi, Yutaka</creatorcontrib><title>Ileal carcinoid tumor complicating carcinoid heart disease and secondary retroperitoneal fibrosis</title><title>Pathology international</title><addtitle>Pathol Int</addtitle><description>A 70‐year‐old man with metastatic liver tumors showed carcinoid syndrome with clinical symptoms of facial flushing, palpitation, dyspnea, and an itching sensation. Regurgitation of the tricuspid and aortic valves was observed by echocardiography. An elevated serum level of serotonin and a high urine excretion of serotonin metabolites were confirmed. Autopsy confirmed a serotonin‐immunoreactive 1 cm ileal carcinoid tumor with metastasis to the liver, bone and peritoneum. The tumor cells were argyrophilic but not argentaffin, and showed erythrophagocytosis in the primary lesion. All the four heart valves and bilateral atrial endocardium showed fibromyxoid thickening, indicating the association of carcinoid heart disease. Desmoplastic reaction with deposition of sulfated acid mucopolysaccharides was also observed in the retroperitoneal space (secondary retroperitoneal fibrosis). Stenosis of the bilateral ureters and inferior mesenteric artery provoked hydronephrosis and lethal ischemic necrosis of the left‐sided colon, respectively. Rarity of functioning ileal carcinoid tumor and pathogenesis of systemic fibroplasia are discussed.</description><subject>Aged</subject><subject>Bone Neoplasms - metabolism</subject><subject>Bone Neoplasms - secondary</subject><subject>carcinoid heart</subject><subject>Carcinoid Heart Disease - etiology</subject><subject>Carcinoid Heart Disease - pathology</subject><subject>carcinoid syndrome</subject><subject>Carcinoid Tumor - complications</subject><subject>Carcinoid Tumor - metabolism</subject><subject>Carcinoid Tumor - secondary</subject><subject>erythrophagocytosis</subject><subject>Humans</subject><subject>ileal carcinoid</subject><subject>Ileal Neoplasms - complications</subject><subject>Ileal Neoplasms - metabolism</subject><subject>Ileal Neoplasms - pathology</subject><subject>Immunoenzyme Techniques</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - secondary</subject><subject>Male</subject><subject>Peritoneal Neoplasms - metabolism</subject><subject>Peritoneal Neoplasms - secondary</subject><subject>Retroperitoneal Fibrosis - etiology</subject><subject>Retroperitoneal Fibrosis - pathology</subject><subject>secondary retroperitoneal fibrosis</subject><subject>serotonin</subject><subject>Serotonin - metabolism</subject><issn>1320-5463</issn><issn>1440-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtOwzAQRS0EoqXwC8grdgnj2HktWKCKRyUELGBtOc4EXCVxsFPR_j0JqVCXrOZKc-fOzCGEMggZiOR6HTIhIGBZlIYRAITAIObh9ojM_xrHg-YRBLFI-Iyceb8GYClP4JTMGGQi5xzmRK1qVDXVymnTWlPSftNYR7Vtutpo1Zv246D5icr1tDQelUeq2pJ61LYtldtRh72zHTrT23aMrEzhrDf-nJxUqvZ4sa8L8n5_97Z8DJ5eHlbL26dAxzzmgVa5ggzjsqiSXGhQUQxRjpDoigmNCfIsT4qi4sODFVdVpEUscg1MZ4qXqeYLcjXlds5-bdD3sjFeY12rFu3Gy5SxNOY8G4zZZNTDfd5hJTtnmuEFyUCOeOVajhTlSFGOeOUvXrkdRi_3OzZFg-XB4MRzMNxMhm9T4-7fwfJ19Twq_gPKyYr3</recordid><startdate>200005</startdate><enddate>200005</enddate><creator>Sakai, Daisuke</creator><creator>Murakami, Masato</creator><creator>Kawazoe, Kazuya</creator><creator>Tsutsumi, Yutaka</creator><general>Blackwell Science Pty</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200005</creationdate><title>Ileal carcinoid tumor complicating carcinoid heart disease and secondary retroperitoneal fibrosis</title><author>Sakai, Daisuke ; Murakami, Masato ; Kawazoe, Kazuya ; Tsutsumi, Yutaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5353-ca9a08e5dbf694c0a25029e06cf14ce6e3896bbf3144f3af2c4549c01c8a3d7c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Aged</topic><topic>Bone Neoplasms - metabolism</topic><topic>Bone Neoplasms - secondary</topic><topic>carcinoid heart</topic><topic>Carcinoid Heart Disease - etiology</topic><topic>Carcinoid Heart Disease - pathology</topic><topic>carcinoid syndrome</topic><topic>Carcinoid Tumor - complications</topic><topic>Carcinoid Tumor - metabolism</topic><topic>Carcinoid Tumor - secondary</topic><topic>erythrophagocytosis</topic><topic>Humans</topic><topic>ileal carcinoid</topic><topic>Ileal Neoplasms - complications</topic><topic>Ileal Neoplasms - metabolism</topic><topic>Ileal Neoplasms - pathology</topic><topic>Immunoenzyme Techniques</topic><topic>Liver Neoplasms - metabolism</topic><topic>Liver Neoplasms - secondary</topic><topic>Male</topic><topic>Peritoneal Neoplasms - metabolism</topic><topic>Peritoneal Neoplasms - secondary</topic><topic>Retroperitoneal Fibrosis - etiology</topic><topic>Retroperitoneal Fibrosis - pathology</topic><topic>secondary retroperitoneal fibrosis</topic><topic>serotonin</topic><topic>Serotonin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sakai, Daisuke</creatorcontrib><creatorcontrib>Murakami, Masato</creatorcontrib><creatorcontrib>Kawazoe, Kazuya</creatorcontrib><creatorcontrib>Tsutsumi, Yutaka</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sakai, Daisuke</au><au>Murakami, Masato</au><au>Kawazoe, Kazuya</au><au>Tsutsumi, Yutaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ileal carcinoid tumor complicating carcinoid heart disease and secondary retroperitoneal fibrosis</atitle><jtitle>Pathology international</jtitle><addtitle>Pathol Int</addtitle><date>2000-05</date><risdate>2000</risdate><volume>50</volume><issue>5</issue><spage>404</spage><epage>411</epage><pages>404-411</pages><issn>1320-5463</issn><eissn>1440-1827</eissn><abstract>A 70‐year‐old man with metastatic liver tumors showed carcinoid syndrome with clinical symptoms of facial flushing, palpitation, dyspnea, and an itching sensation. Regurgitation of the tricuspid and aortic valves was observed by echocardiography. An elevated serum level of serotonin and a high urine excretion of serotonin metabolites were confirmed. Autopsy confirmed a serotonin‐immunoreactive 1 cm ileal carcinoid tumor with metastasis to the liver, bone and peritoneum. The tumor cells were argyrophilic but not argentaffin, and showed erythrophagocytosis in the primary lesion. All the four heart valves and bilateral atrial endocardium showed fibromyxoid thickening, indicating the association of carcinoid heart disease. Desmoplastic reaction with deposition of sulfated acid mucopolysaccharides was also observed in the retroperitoneal space (secondary retroperitoneal fibrosis). Stenosis of the bilateral ureters and inferior mesenteric artery provoked hydronephrosis and lethal ischemic necrosis of the left‐sided colon, respectively. Rarity of functioning ileal carcinoid tumor and pathogenesis of systemic fibroplasia are discussed.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Science Pty</pub><pmid>10849330</pmid><doi>10.1046/j.1440-1827.2000.01053.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Bone Neoplasms - metabolism Bone Neoplasms - secondary carcinoid heart Carcinoid Heart Disease - etiology Carcinoid Heart Disease - pathology carcinoid syndrome Carcinoid Tumor - complications Carcinoid Tumor - metabolism Carcinoid Tumor - secondary erythrophagocytosis Humans ileal carcinoid Ileal Neoplasms - complications Ileal Neoplasms - metabolism Ileal Neoplasms - pathology Immunoenzyme Techniques Liver Neoplasms - metabolism Liver Neoplasms - secondary Male Peritoneal Neoplasms - metabolism Peritoneal Neoplasms - secondary Retroperitoneal Fibrosis - etiology Retroperitoneal Fibrosis - pathology secondary retroperitoneal fibrosis serotonin Serotonin - metabolism |
| title | Ileal carcinoid tumor complicating carcinoid heart disease and secondary retroperitoneal fibrosis |
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