Experimental Abdominal Aortic Aneurysms in Mice Lacking Expression of Inducible Nitric Oxide Synthase

To determine if nitric oxide synthase (NOS) contributes to the pathophysiology of abdominal aortic aneurysms (AAAs), C57BL/6J mice underwent transient aortic injury to induce a chronic inflammatory response. Wild-type mice developed a significant increase in aortic diameter within 14 days of elastas...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2001-09, Vol.21 (9), p.1393-1401
Hauptverfasser:	Lee, Jason K, Borhani, Martin, Ennis, Terri L, Upchurch, Gilbert R, Thompson, Robert W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aortic Aneurysm, Abdominal - etiology Aortic Aneurysm, Abdominal - metabolism Aortic Aneurysm, Abdominal - pathology Biological and medical sciences Cardiac dysrhythmias Cardiology. Vascular system Dilatation, Pathologic Female Heart Male Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Nitric Oxide Synthase - biosynthesis Nitric Oxide Synthase - genetics Nitric Oxide Synthase Type II Ovariectomy Pancreatic Elastase RNA, Messenger - biosynthesis Tyrosine - analogs & derivatives Tyrosine - metabolism
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