On the Stability of Double Stranded Nucleic Acids

We present the first pressure-versus-temperature phase diagram for the helix-to-coil transition of double stranded nucleic acids. The thermodynamic stability of a nucleic acid duplex is a complex function of temperature and pressure and strongly depends on the denaturation temperature, T M, of the d...

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Veröffentlicht in:	Journal of the American Chemical Society 2001-09, Vol.123 (38), p.9254-9259
Hauptverfasser:	Dubins, David N, Lee, Adrian, Macgregor, Robert B, Chalikian, Tigran V
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA - chemistry Hot Temperature Nucleic Acid Conformation Poly A - chemistry Poly A-U - chemistry Poly U - chemistry Polydeoxyribonucleotides - chemistry Pressure RNA - chemistry Spectrophotometry, Ultraviolet Thermodynamics
Online-Zugang:	Volltext
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