Unravelling the mysteries of virulence gene regulation in Salmonella typhimurium
Salmonella typhimurium, which causes gastroenteritis in calves and humans as well as a typhoid‐like disease in mice, uses numerous virulence factors to infect its hosts. Genes encoding these factors are regulated by many environmental conditions and regulatory pathways in vitro. Many virulence genes...
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| Veröffentlicht in: | Molecular microbiology 2000-06, Vol.36 (5), p.1024-1033 |
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| creator | Lucas, Robin L. Lee, Catherine A. |
| description | Salmonella typhimurium, which causes gastroenteritis in calves and humans as well as a typhoid‐like disease in mice, uses numerous virulence factors to infect its hosts. Genes encoding these factors are regulated by many environmental conditions and regulatory pathways in vitro. Many virulence genes are specifically induced at particular sites during infection or in cultured host cells. The complex regulation of virulence genes observed in vitro may be necessary to restrict their expression to specific locations within the host. In vitro and in vivo studies provide clues about how virulence genes might be regulated in vivo. Future studies must assess the actual environmental signals and regulators that modulate each virulence gene in vivo and determine how multiple regulatory pathways are integrated to co‐ordinate the appropriate expression of virulence factors at specific sites in vivo. |
| doi_str_mv | 10.1046/j.1365-2958.2000.01961.x |
| format | Article |
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Genes encoding these factors are regulated by many environmental conditions and regulatory pathways in vitro. Many virulence genes are specifically induced at particular sites during infection or in cultured host cells. The complex regulation of virulence genes observed in vitro may be necessary to restrict their expression to specific locations within the host. In vitro and in vivo studies provide clues about how virulence genes might be regulated in vivo. Future studies must assess the actual environmental signals and regulators that modulate each virulence gene in vivo and determine how multiple regulatory pathways are integrated to co‐ordinate the appropriate expression of virulence factors at specific sites in vivo.</description><identifier>ISSN: 0950-382X</identifier><identifier>EISSN: 1365-2958</identifier><identifier>DOI: 10.1046/j.1365-2958.2000.01961.x</identifier><identifier>PMID: 10844688</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Animals ; Environment ; Gene Expression Regulation, Bacterial ; Mice ; Models, Genetic ; Salmonella typhimurium ; Salmonella typhimurium - genetics ; Salmonella typhimurium - pathogenicity ; Signal Transduction ; Virulence - genetics ; virulence factors</subject><ispartof>Molecular microbiology, 2000-06, Vol.36 (5), p.1024-1033</ispartof><rights>Copyright Blackwell Scientific Publications Ltd. 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Genes encoding these factors are regulated by many environmental conditions and regulatory pathways in vitro. Many virulence genes are specifically induced at particular sites during infection or in cultured host cells. The complex regulation of virulence genes observed in vitro may be necessary to restrict their expression to specific locations within the host. In vitro and in vivo studies provide clues about how virulence genes might be regulated in vivo. Future studies must assess the actual environmental signals and regulators that modulate each virulence gene in vivo and determine how multiple regulatory pathways are integrated to co‐ordinate the appropriate expression of virulence factors at specific sites in vivo.</description><subject>Animals</subject><subject>Environment</subject><subject>Gene Expression Regulation, Bacterial</subject><subject>Mice</subject><subject>Models, Genetic</subject><subject>Salmonella typhimurium</subject><subject>Salmonella typhimurium - genetics</subject><subject>Salmonella typhimurium - pathogenicity</subject><subject>Signal Transduction</subject><subject>Virulence - genetics</subject><subject>virulence factors</subject><issn>0950-382X</issn><issn>1365-2958</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1P3DAQhq2qCJaPv1BZPfSW4Injr0MPFYKCBAIJVuJmZZ3ZxavE2ToJsP--DkuriktPHvl9bM3MQwgFlgMr5ek6By5FVhih84IxljMwEvLXT2T2N_hMZswIlnFdPB6Qw75fMwacSb5PDoDpspRaz8jdPMTqGZvGhxUdnpC2237A6LGn3ZI--zg2GBzSFQakEVdjUw2-C9QHel81bRfS04oO282Tb8fox_aY7C2rpseT9_OIzC_OH84us-vbn1dnP64zx1UJWa3ALApTmoVYlBKdQ4caQXPplqqqUwRCSlPXqCthQPLalaoWyrl0t1SKH5Fvu383sfs1Yj_Y1vdu6iZgN_ZWASiQhfkvCEqnPkAk8OsHcN2NMaQhbNquACl0maAv79C4aLG2m-jbKm7tn40m4PsOePENbv_J7WTOru0kyE6C7GTOvpmzr_bm5mqq-G8AdIz5</recordid><startdate>200006</startdate><enddate>200006</enddate><creator>Lucas, Robin L.</creator><creator>Lee, Catherine A.</creator><general>Blackwell Science Ltd</general><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>200006</creationdate><title>Unravelling the mysteries of virulence gene regulation in Salmonella typhimurium</title><author>Lucas, Robin L. ; Lee, Catherine A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3741-d719b2949b5b46eccece8e1836cf7adb2915669dde8a59163dc47d57cc9ddf773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Environment</topic><topic>Gene Expression Regulation, Bacterial</topic><topic>Mice</topic><topic>Models, Genetic</topic><topic>Salmonella typhimurium</topic><topic>Salmonella typhimurium - genetics</topic><topic>Salmonella typhimurium - pathogenicity</topic><topic>Signal Transduction</topic><topic>Virulence - genetics</topic><topic>virulence factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lucas, Robin L.</creatorcontrib><creatorcontrib>Lee, Catherine A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lucas, Robin L.</au><au>Lee, Catherine A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unravelling the mysteries of virulence gene regulation in Salmonella typhimurium</atitle><jtitle>Molecular microbiology</jtitle><addtitle>Mol Microbiol</addtitle><date>2000-06</date><risdate>2000</risdate><volume>36</volume><issue>5</issue><spage>1024</spage><epage>1033</epage><pages>1024-1033</pages><issn>0950-382X</issn><eissn>1365-2958</eissn><abstract>Salmonella typhimurium, which causes gastroenteritis in calves and humans as well as a typhoid‐like disease in mice, uses numerous virulence factors to infect its hosts. 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| ispartof | Molecular microbiology, 2000-06, Vol.36 (5), p.1024-1033 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Environment Gene Expression Regulation, Bacterial Mice Models, Genetic Salmonella typhimurium Salmonella typhimurium - genetics Salmonella typhimurium - pathogenicity Signal Transduction Virulence - genetics virulence factors |
| title | Unravelling the mysteries of virulence gene regulation in Salmonella typhimurium |
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