NTS A(2a) purinoceptor activation elicits hindlimb vasodilation primarily via a beta-adrenergic mechanism

Previously, we have shown that activation of adenosine A(2a) receptors in the subpostremal nucleus tractus solitarii (NTS) via microinjection of the selective A(2a) receptor agonist CGS-21680 elicits potent, dose-dependent decreases in mean arterial pressure and preferential, marked hindlimb vasodil...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2000-06, Vol.278 (6), p.H1775-H1782
Hauptverfasser:	Kitchen, A M, Scislo, T J, O'Leary, D S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - pharmacology Adrenal Glands - physiology Adrenergic beta-Antagonists - pharmacology Animals Blood Pressure - drug effects Cardiovascular Physiological Phenomena Hindlimb - blood supply Lumbosacral Region Male Phenethylamines - pharmacology Propranolol - pharmacology Rats Rats, Sprague-Dawley Receptor, Adenosine A2A Receptors, Adrenergic, beta - physiology Receptors, Purinergic P1 - physiology Solitary Nucleus - metabolism Sympathetic Nervous System - physiology Vasoconstriction Vasodilation - physiology
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