Glucocorticoids Regulate TCR-Induced Elevation of CD4: Functional Implications

CD4 serves as a coreceptor during Ag recognition by the TCR. This interaction results in a marked increase in the sensitivity of a T cell to Ag presented by MHC class II molecules. Here we report that activation of T cells either by plate-bound mAb (anti-TCR, anti-CD3) or soluble activators (staphyl...

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Veröffentlicht in:	The Journal of immunology (1950) 2000-06, Vol.164 (12), p.6213-6220
Hauptverfasser:	Wiegers, G. Jan, Stec, Ilona E. M, Klinkert, Wolfgang E. F, Reul, Johannes M. H. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - antagonists & inhibitors Adjuvants, Immunologic - pharmacology AIDS/HIV Animals Antibodies, Monoclonal - pharmacology CD4 antigen CD4 Antigens - biosynthesis CD4 Antigens - immunology CD4 Antigens - physiology CD4-Positive T-Lymphocytes - immunology Cells, Cultured Corticosterone - antagonists & inhibitors Corticosterone - pharmacology Corticosterone - physiology Down-Regulation - drug effects Down-Regulation - immunology Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Male Mifepristone - pharmacology Rats Rats, Wistar Receptors, Antigen, T-Cell - antagonists & inhibitors Receptors, Antigen, T-Cell - biosynthesis Receptors, Antigen, T-Cell - physiology Receptors, Glucocorticoid - antagonists & inhibitors T-Lymphocytes - drug effects T-Lymphocytes - immunology T-Lymphocytes - metabolism
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