Impaired Superoxide Production Due to a Deficiency in Phagocyte NADPH Oxidase Fails to Inhibit Atherosclerosis in Mice

Superoxide, the reduced form of molecular oxygen, has been implicated in the genesis of vascular disease. One potential mechanism involves oxidation of low density lipoprotein into an atherogenic particle. A second involves reaction with nitric oxide to generate peroxynitrite, a highly oxidizing int...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2000-06, Vol.20 (6), p.1529-1535
Hauptverfasser:	Kirk, Elizabeth A, Dinauer, Mary C, Rosen, Henry, Chait, Alan, Heinecke, Jay W, LeBoeuf, Renée C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoproteins E - deficiency Apolipoproteins E - genetics Arteriosclerosis - blood Arteriosclerosis - genetics Arteriosclerosis - prevention & control Cholesterol - blood Female Gene Expression Male Mice Mice, Inbred C57BL NADH, NADPH Oxidoreductases - genetics NADPH Oxidases - deficiency NADPH Oxidases - genetics Phagocytes - enzymology Phagocytes - metabolism RNA, Messenger - metabolism Sex Characteristics Superoxides - metabolism Triglycerides - blood
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