Up-regulation of macrophage inflammatory protein-3 alpha/CCL20 and CC chemokine receptor 6 in psoriasis

Autoimmunity plays a key role in the immunopathogenesis of psoriasis; however, little is known about the recruitment of pathogenic cells to skin lesions. We report here that the CC chemokine, macrophage inflammatory protein-3 alpha, recently renamed CCL20, and its receptor CCR6 are markedly up-regul...

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Veröffentlicht in:	The Journal of immunology (1950) 2000-06, Vol.164 (12), p.6621-6632
Hauptverfasser:	Homey, B, Dieu-Nosjean, M C, Wiesenborn, A, Massacrier, C, Pin, J J, Oldham, E, Catron, D, Buchanan, M E, Müller, A, deWaal Malefyt, R, Deng, G, Orozco, R, Ruzicka, T, Lehmann, P, Lebecque, S, Caux, C, Zlotnik, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Differentiation, T-Lymphocyte Antigens, Neoplasm CCL20 protein CCR6 protein CD40 Ligand CD40L protein Chemokine CCL20 Chemokines, CC Chemotaxis, Leukocyte - immunology Dose-Response Relationship, Immunologic g-Interferon Humans Interferon-gamma - physiology Interleukin 1^a Interleukin-1 - physiology Interleukin-17 - physiology macrophage inflammatory protein 3^a Macrophage Inflammatory Proteins - biosynthesis Macrophage Inflammatory Proteins - metabolism Macrophage Inflammatory Proteins - physiology Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - physiology Psoriasis - immunology Psoriasis - metabolism Psoriasis - pathology Receptors, CCR6 Receptors, Chemokine - biosynthesis Receptors, Lymphocyte Homing - biosynthesis Skin - cytology Skin - immunology Skin - metabolism T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Tumor Necrosis Factor-alpha - physiology Up-Regulation - immunology
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