Soluble Type II Transforming Growth Factor-β (TGF-β) Receptor Inhibits TGF-β Signaling in COLO-357 Pancreatic Cancer Cells in Vitro and Attenuates Tumor Formation

Human pancreatic ductal adenocarcinomas overexpress transforming growth factor-βs (TGF-βs). This overexpression has been correlated with decreased patient survival. TGF-βs bind to a type II TGF-β receptor (TβRII) dimer, which heterotetramerizes with a type I TGF-β receptor (TβRI) dimer, thereby acti...

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Veröffentlicht in:	Clinical cancer research 2001-09, Vol.7 (9), p.2931-2940
Hauptverfasser:	ROWLAND-GOLDSMITH, Melissa A, MARUYAMA, Haruhisa, KUSAMA, Toshiyuki, RALLI, Sonia, KORC, Murray
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Cell Division - drug effects Cell Division - genetics Cell Movement - drug effects Chemotherapy Female Gene Expression Genetic Vectors - genetics Humans Medical sciences Mice Mice, Nude Neoplasm Invasiveness Neoplasm Transplantation Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Pancreatic Neoplasms - therapy Pharmacology. Drug treatments Receptors, Transforming Growth Factor beta - genetics Receptors, Transforming Growth Factor beta - metabolism Signal Transduction Solubility Transfection Transforming Growth Factor beta - metabolism Transforming Growth Factor beta - pharmacology Transforming Growth Factor beta1 Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - metabolism Xenograft Model Antitumor Assays
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