Fas ligand expression by neoplastic T lymphocytes mediates elimination of CD8+ cytotoxic T lymphocytes in mycosis fungoides : A potential mechanism of tumor immune escape?

Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma (CTCL) and arises from the accumulation and clonal proliferation of epidermotropic, CD4+/CD45RO+ (helper/memory) T lymphocytes. Loss of CD8+ CTLs within MF lesions is associated with poor prognosis and disease progression. B...

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Veröffentlicht in:	Clinical cancer research 2001-09, Vol.7 (9), p.2682-2692
Hauptverfasser:	XIAO NI, HAZARIKA, Parul, CHUNLEI ZHANG, TALPUR, Rakhashandra, DUVIC, Madeleine
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Apoptosis Biological and medical sciences CD8 Antigens - metabolism Fas Ligand Protein Female General aspects (metabolism, cell proliferation, established cell line...) Humans Immunohistochemistry In Situ Nick-End Labeling Jurkat Cells Leukocyte Common Antigens - metabolism Male Medical sciences Membrane Glycoproteins - biosynthesis Middle Aged Mycosis Fungoides - immunology Mycosis Fungoides - metabolism Mycosis Fungoides - pathology Skin - chemistry Skin - immunology Skin - pathology Skin Neoplasms - immunology Skin Neoplasms - metabolism Skin Neoplasms - pathology T-Lymphocytes - chemistry T-Lymphocytes - immunology T-Lymphocytes - pathology T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - metabolism T-Lymphocytes, Cytotoxic - pathology Tumor cell Tumor Cells, Cultured Tumors
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