Influence of Aging and Other Cardiovascular Risk Factors on Baroreflex Sensitivity
OBJECTIVES: To examine the influence of known cardiovascular risk factors (cholesterol, blood glucose levels, arterial pressures, heart rate, and aging) on baroreflex sensitivity. DESIGN: An observational epidemiological study. SETTING: Geriatric Division at the Policlinico Umberto Primo, University...
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| Veröffentlicht in: | Journal of the American Geriatrics Society (JAGS) 2001-08, Vol.49 (8), p.1059-1065 |
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| container_title | Journal of the American Geriatrics Society (JAGS) |
| container_volume | 49 |
| creator | Piccirillo, Gianfranco Di Giuseppe, Vincenza Nocco, Marialuce Lionetti, Marco Moisè, Antonio Naso, Camilla Tallarico, Demetrio Marigliano, Vincenzo Cacciafesta, Mauro |
| description | OBJECTIVES: To examine the influence of known cardiovascular risk factors (cholesterol, blood glucose levels, arterial pressures, heart rate, and aging) on baroreflex sensitivity.
DESIGN: An observational epidemiological study.
SETTING: Geriatric Division at the Policlinico Umberto Primo, University of Rome La Sapienza.
PARTICIPANTS: Two hundred three subjects whose ages ranged from 9 to 94 years, apparently healthy and free of detectable clinical evidence of atherosclerosis.
MEASUREMENTS: All subjects underwent determination of baroreflex sensitivity by phenylephrine infusion (BSphe), and by a noninvasive method derived from spectral analysis of R‐R interval and arterial pressure variabilities (α index).
RESULTS: The population, subdivided into tertiles for each variable studied, had lower BSphe values and lower α indexes as a function of age, plasma low‐density lipoprotein (LDL) cholesterol, and systolic blood pressure. The α index was significantly lower in both groups with elevated LDL cholesterol levels than in those with lower levels (II and III vs I tertile, P < .001), whereas BSphe differed significantly only in the two groups who had extreme levels of LDL (I vs III tertile, P < .001). Multiple regression analysis identified a negative association of the α index with age (P < .001), heart rate (P < .01), area under the glucose‐response curve (P < .001), and LDL cholesterol (P < .01), but of BSphe only with age (P < .001) and heart rate (P < .01).
CONCLUSION: These findings indicate that some risk factors for coronary heart disease adversely influence baroreflex sensitivity. |
| doi_str_mv | 10.1046/j.1532-5415.2001.49209.x |
| format | Article |
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DESIGN: An observational epidemiological study.
SETTING: Geriatric Division at the Policlinico Umberto Primo, University of Rome La Sapienza.
PARTICIPANTS: Two hundred three subjects whose ages ranged from 9 to 94 years, apparently healthy and free of detectable clinical evidence of atherosclerosis.
MEASUREMENTS: All subjects underwent determination of baroreflex sensitivity by phenylephrine infusion (BSphe), and by a noninvasive method derived from spectral analysis of R‐R interval and arterial pressure variabilities (α index).
RESULTS: The population, subdivided into tertiles for each variable studied, had lower BSphe values and lower α indexes as a function of age, plasma low‐density lipoprotein (LDL) cholesterol, and systolic blood pressure. The α index was significantly lower in both groups with elevated LDL cholesterol levels than in those with lower levels (II and III vs I tertile, P < .001), whereas BSphe differed significantly only in the two groups who had extreme levels of LDL (I vs III tertile, P < .001). Multiple regression analysis identified a negative association of the α index with age (P < .001), heart rate (P < .01), area under the glucose‐response curve (P < .001), and LDL cholesterol (P < .01), but of BSphe only with age (P < .001) and heart rate (P < .01).
CONCLUSION: These findings indicate that some risk factors for coronary heart disease adversely influence baroreflex sensitivity.]]></description><identifier>ISSN: 0002-8614</identifier><identifier>EISSN: 1532-5415</identifier><identifier>DOI: 10.1046/j.1532-5415.2001.49209.x</identifier><identifier>PMID: 11555067</identifier><identifier>CODEN: JAGSAF</identifier><language>eng</language><publisher>Boston, MA, USA: Blackwell Science Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Ageing ; Aging ; Aging - physiology ; Analysis of Variance ; autonomic nervous system ; autonomic neuropathy ; Baroreflex - physiology ; Baroreflex sensitivity ; Biological and medical sciences ; Blood Glucose ; Blood Pressure ; Cardiology. Vascular system ; Cardiovascular disease ; Cardiovascular system ; Case-Control Studies ; Child ; Cholesterol ; Cholesterol - blood ; Elderly people ; endothelial dysfunction ; Female ; Health risk assessment ; Heart ; Heart failure, cardiogenic pulmonary edema, cardiac enlargement ; Heart Rate ; Humans ; hypertension ; Influence ; Italy ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Nervous system ; power spectral analysis ; Regression Analysis ; Ventricular Function, Left</subject><ispartof>Journal of the American Geriatrics Society (JAGS), 2001-08, Vol.49 (8), p.1059-1065</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright Lippincott Williams & Wilkins Aug 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4929-a7c05689be73102f0733159123b9f664702133b5543a02315aff6e0f19382c483</citedby><cites>FETCH-LOGICAL-c4929-a7c05689be73102f0733159123b9f664702133b5543a02315aff6e0f19382c483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1532-5415.2001.49209.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1532-5415.2001.49209.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,30981,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14068832$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11555067$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Piccirillo, Gianfranco</creatorcontrib><creatorcontrib>Di Giuseppe, Vincenza</creatorcontrib><creatorcontrib>Nocco, Marialuce</creatorcontrib><creatorcontrib>Lionetti, Marco</creatorcontrib><creatorcontrib>Moisè, Antonio</creatorcontrib><creatorcontrib>Naso, Camilla</creatorcontrib><creatorcontrib>Tallarico, Demetrio</creatorcontrib><creatorcontrib>Marigliano, Vincenzo</creatorcontrib><creatorcontrib>Cacciafesta, Mauro</creatorcontrib><title>Influence of Aging and Other Cardiovascular Risk Factors on Baroreflex Sensitivity</title><title>Journal of the American Geriatrics Society (JAGS)</title><addtitle>Journal of the American Geriatrics Society</addtitle><description><![CDATA[OBJECTIVES: To examine the influence of known cardiovascular risk factors (cholesterol, blood glucose levels, arterial pressures, heart rate, and aging) on baroreflex sensitivity.
DESIGN: An observational epidemiological study.
SETTING: Geriatric Division at the Policlinico Umberto Primo, University of Rome La Sapienza.
PARTICIPANTS: Two hundred three subjects whose ages ranged from 9 to 94 years, apparently healthy and free of detectable clinical evidence of atherosclerosis.
MEASUREMENTS: All subjects underwent determination of baroreflex sensitivity by phenylephrine infusion (BSphe), and by a noninvasive method derived from spectral analysis of R‐R interval and arterial pressure variabilities (α index).
RESULTS: The population, subdivided into tertiles for each variable studied, had lower BSphe values and lower α indexes as a function of age, plasma low‐density lipoprotein (LDL) cholesterol, and systolic blood pressure. The α index was significantly lower in both groups with elevated LDL cholesterol levels than in those with lower levels (II and III vs I tertile, P < .001), whereas BSphe differed significantly only in the two groups who had extreme levels of LDL (I vs III tertile, P < .001). Multiple regression analysis identified a negative association of the α index with age (P < .001), heart rate (P < .01), area under the glucose‐response curve (P < .001), and LDL cholesterol (P < .01), but of BSphe only with age (P < .001) and heart rate (P < .01).
CONCLUSION: These findings indicate that some risk factors for coronary heart disease adversely influence baroreflex sensitivity.]]></description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Ageing</subject><subject>Aging</subject><subject>Aging - physiology</subject><subject>Analysis of Variance</subject><subject>autonomic nervous system</subject><subject>autonomic neuropathy</subject><subject>Baroreflex - physiology</subject><subject>Baroreflex sensitivity</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose</subject><subject>Blood Pressure</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular system</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Cholesterol</subject><subject>Cholesterol - blood</subject><subject>Elderly people</subject><subject>endothelial dysfunction</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Heart</subject><subject>Heart failure, cardiogenic pulmonary edema, cardiac enlargement</subject><subject>Heart Rate</subject><subject>Humans</subject><subject>hypertension</subject><subject>Influence</subject><subject>Italy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Nervous system</subject><subject>power spectral analysis</subject><subject>Regression Analysis</subject><subject>Ventricular Function, Left</subject><issn>0002-8614</issn><issn>1532-5415</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqNkU1vEzEQhi0EoqHwF5CFBLddPPb6Yy9IbURCUWlRA-JoORu7ON2si71bkn-Pt4laiQucbGmeeT3jByEMpARSiffrEjijBa-Al5QQKKuakrrcPkGTh8JTNCGE0EIJqI7Qi5TWGaREqefoCIBzToScoKuzzrWD7RqLg8Mn1767xqZb4cv-p414auLKhzuTmqE1EV_5dINnpulDTDh0-NTEEK1r7RYvbJd87-98v3uJnjnTJvvqcB6j77OP36afivPL-dn05Lxo8rR1YWRDuFD10koGhDoiGQNeA2XL2glRSUKBsSXnFTOE5pJxTljioGaKNpVix-jdPvc2hl-DTb3e-NTYtjWdDUPSEkAoWdf_BLmUXACHDL75C1yHIXZ5CU2B5Ge5HCG1h5oYUsrr69voNybuNBA92tFrPUrQowQ92tH3dvQ2t74-5A_LjV09Nh50ZODtAchfbloXTdf49MhVRCjFaOY-7LnfvrW7_x5Af54v7q85oNgH-NTb7UOAiTc6jyG5_nEx11--stlifir0BfsDhue21g</recordid><startdate>200108</startdate><enddate>200108</enddate><creator>Piccirillo, Gianfranco</creator><creator>Di Giuseppe, Vincenza</creator><creator>Nocco, Marialuce</creator><creator>Lionetti, Marco</creator><creator>Moisè, Antonio</creator><creator>Naso, Camilla</creator><creator>Tallarico, Demetrio</creator><creator>Marigliano, Vincenzo</creator><creator>Cacciafesta, Mauro</creator><general>Blackwell Science Inc</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7QJ</scope><scope>7X8</scope></search><sort><creationdate>200108</creationdate><title>Influence of Aging and Other Cardiovascular Risk Factors on Baroreflex Sensitivity</title><author>Piccirillo, Gianfranco ; Di Giuseppe, Vincenza ; Nocco, Marialuce ; Lionetti, Marco ; Moisè, Antonio ; Naso, Camilla ; Tallarico, Demetrio ; Marigliano, Vincenzo ; Cacciafesta, Mauro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4929-a7c05689be73102f0733159123b9f664702133b5543a02315aff6e0f19382c483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Ageing</topic><topic>Aging</topic><topic>Aging - physiology</topic><topic>Analysis of Variance</topic><topic>autonomic nervous system</topic><topic>autonomic neuropathy</topic><topic>Baroreflex - physiology</topic><topic>Baroreflex sensitivity</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose</topic><topic>Blood Pressure</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular system</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Cholesterol</topic><topic>Cholesterol - blood</topic><topic>Elderly people</topic><topic>endothelial dysfunction</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Heart</topic><topic>Heart failure, cardiogenic pulmonary edema, cardiac enlargement</topic><topic>Heart Rate</topic><topic>Humans</topic><topic>hypertension</topic><topic>Influence</topic><topic>Italy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Nervous system</topic><topic>power spectral analysis</topic><topic>Regression Analysis</topic><topic>Ventricular Function, Left</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Piccirillo, Gianfranco</creatorcontrib><creatorcontrib>Di Giuseppe, Vincenza</creatorcontrib><creatorcontrib>Nocco, Marialuce</creatorcontrib><creatorcontrib>Lionetti, Marco</creatorcontrib><creatorcontrib>Moisè, Antonio</creatorcontrib><creatorcontrib>Naso, Camilla</creatorcontrib><creatorcontrib>Tallarico, Demetrio</creatorcontrib><creatorcontrib>Marigliano, Vincenzo</creatorcontrib><creatorcontrib>Cacciafesta, Mauro</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Piccirillo, Gianfranco</au><au>Di Giuseppe, Vincenza</au><au>Nocco, Marialuce</au><au>Lionetti, Marco</au><au>Moisè, Antonio</au><au>Naso, Camilla</au><au>Tallarico, Demetrio</au><au>Marigliano, Vincenzo</au><au>Cacciafesta, Mauro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Aging and Other Cardiovascular Risk Factors on Baroreflex Sensitivity</atitle><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle><addtitle>Journal of the American Geriatrics Society</addtitle><date>2001-08</date><risdate>2001</risdate><volume>49</volume><issue>8</issue><spage>1059</spage><epage>1065</epage><pages>1059-1065</pages><issn>0002-8614</issn><eissn>1532-5415</eissn><coden>JAGSAF</coden><abstract><![CDATA[OBJECTIVES: To examine the influence of known cardiovascular risk factors (cholesterol, blood glucose levels, arterial pressures, heart rate, and aging) on baroreflex sensitivity.
DESIGN: An observational epidemiological study.
SETTING: Geriatric Division at the Policlinico Umberto Primo, University of Rome La Sapienza.
PARTICIPANTS: Two hundred three subjects whose ages ranged from 9 to 94 years, apparently healthy and free of detectable clinical evidence of atherosclerosis.
MEASUREMENTS: All subjects underwent determination of baroreflex sensitivity by phenylephrine infusion (BSphe), and by a noninvasive method derived from spectral analysis of R‐R interval and arterial pressure variabilities (α index).
RESULTS: The population, subdivided into tertiles for each variable studied, had lower BSphe values and lower α indexes as a function of age, plasma low‐density lipoprotein (LDL) cholesterol, and systolic blood pressure. The α index was significantly lower in both groups with elevated LDL cholesterol levels than in those with lower levels (II and III vs I tertile, P < .001), whereas BSphe differed significantly only in the two groups who had extreme levels of LDL (I vs III tertile, P < .001). Multiple regression analysis identified a negative association of the α index with age (P < .001), heart rate (P < .01), area under the glucose‐response curve (P < .001), and LDL cholesterol (P < .01), but of BSphe only with age (P < .001) and heart rate (P < .01).
CONCLUSION: These findings indicate that some risk factors for coronary heart disease adversely influence baroreflex sensitivity.]]></abstract><cop>Boston, MA, USA</cop><pub>Blackwell Science Inc</pub><pmid>11555067</pmid><doi>10.1046/j.1532-5415.2001.49209.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Ageing Aging Aging - physiology Analysis of Variance autonomic nervous system autonomic neuropathy Baroreflex - physiology Baroreflex sensitivity Biological and medical sciences Blood Glucose Blood Pressure Cardiology. Vascular system Cardiovascular disease Cardiovascular system Case-Control Studies Child Cholesterol Cholesterol - blood Elderly people endothelial dysfunction Female Health risk assessment Heart Heart failure, cardiogenic pulmonary edema, cardiac enlargement Heart Rate Humans hypertension Influence Italy Male Medical sciences Middle Aged Multivariate Analysis Nervous system power spectral analysis Regression Analysis Ventricular Function, Left |
| title | Influence of Aging and Other Cardiovascular Risk Factors on Baroreflex Sensitivity |
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