Application of the PKCYP-test in Cases of Altered CYP1A2 for Multiple CYP Systems in Rat Models of Disease

Previously, we established a method to assess drug metabolism capacity based on a pharmacokinetic estimation of the quantity of cytochrome P450 (CYP) in vivo (PKCYP-test) by introducing an apparent liver-to-blood free concentration gradient in vivo (qg). The qg values were determined as the ratio of...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2001, Vol.24(9), pp.1037-1043
Hauptverfasser:	MATSUNAGA, Noriko, HATTORI, Kenji, IIZASA, Hisashi, KIZU, Junko, TAKANAKA, Akira, NAKASHIMA, Emi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetanilides - pharmacokinetics aged Aging - metabolism Algorithms Animals Antibodies, Blocking - pharmacology Biological and medical sciences Caffeine - pharmacokinetics Central Nervous System Stimulants - pharmacokinetics Choline Deficiency - enzymology choline-deficient CYP1A2 Cytochrome P-450 CYP1A2 - metabolism Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - metabolism Diet Disease Models, Animal Enzyme Inhibitors - pharmacology General pharmacology Isoenzymes - metabolism Liver Circulation - drug effects Male Medical sciences Methylcholanthrene - pharmacology Microsomes, Liver - drug effects Microsomes, Liver - metabolism Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments PKCCYP-test probe Rats Rats, Sprague-Dawley
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