Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens
The striatum and its ventral extension, the nucleus accumbens, are involved in behaviors as diverse as motor planning, drug seeking, and learning. Invariably, these striatally mediated behaviors depend on intact dopaminergic innervation. However, the mechanisms by which dopamine modulates neuronal f...
Gespeichert in:
| Veröffentlicht in: | Annual review of neuroscience 2000-01, Vol.23 (1), p.185-215 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 215 |
|---|---|
| container_issue | 1 |
| container_start_page | 185 |
| container_title | Annual review of neuroscience |
| container_volume | 23 |
| creator | NICOLA, S. M SURMEIER, D. J MALENKA, R. C |
| description | The striatum and its ventral extension, the nucleus accumbens, are involved in behaviors as diverse as motor planning, drug seeking, and learning. Invariably, these striatally mediated behaviors depend on intact dopaminergic innervation. However, the mechanisms by which dopamine modulates neuronal function in the striatum and nucleus accumbens have been difficult to elucidate. Recent electrophysiological studies have revealed that dopamine alters both voltage-dependent conductances and synaptic transmission, resulting in state-dependent modulation of target cells. These studies make clear predictions about how dopamine, particularly via D1 receptor activation, should alter the responsiveness of striatal neurons to extrinsic excitatory synaptic activity. |
| doi_str_mv | 10.1146/annurev.neuro.23.1.185 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71167469</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>54142182</sourcerecordid><originalsourceid>FETCH-LOGICAL-c462t-eb15174ec78262996756cca96afee628e94984fe8f25cc0b31cf8c342a8ac1673</originalsourceid><addsrcrecordid>eNqF0Utv1DAUBWALgehQ-AuVhRC7BL9jL1HLS6rEBhA768ZzA64Se7BjRP89aWckEBtWd_PdsziHkAvOes6VeQUptYI_-4St5F7Invfc6gdkx7XSneLCPCQ7xtXQMWa-npEntd4wxpyU7jE548wqzYzckS9X-QBLTFi-xUCXvG8zrDEnmid6n51gpvgrxBXGOMf1lsZE1-9I61oirG2hkPY0tTBjqxRCaMuIqT4ljyaYKz473XPy-e2bT5fvu-uP7z5cvr7ugjJi7XDkmg8Kw2CFEc6ZQZsQwBmYEI2w6JSzakI7CR0CGyUPkw1SCbAQuBnkOXl5zD2U_KNhXf0Sa8B5hoS5VT_wTSnj_gv5oOUghN7g83_gTW5la2Ezzlo7aHWXZo4olFxrwckfSlyg3HrO_N0-_rSPv-_QC-m53_bZHi9O6W1ccP_X23GQDbw4AagB5qlACrH-cVILKZz8DTKSnas</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>198887549</pqid></control><display><type>article</type><title>Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens</title><source>Annual Reviews Complete A-Z List</source><source>MEDLINE</source><creator>NICOLA, S. M ; SURMEIER, D. J ; MALENKA, R. C</creator><creatorcontrib>NICOLA, S. M ; SURMEIER, D. J ; MALENKA, R. C</creatorcontrib><description>The striatum and its ventral extension, the nucleus accumbens, are involved in behaviors as diverse as motor planning, drug seeking, and learning. Invariably, these striatally mediated behaviors depend on intact dopaminergic innervation. However, the mechanisms by which dopamine modulates neuronal function in the striatum and nucleus accumbens have been difficult to elucidate. Recent electrophysiological studies have revealed that dopamine alters both voltage-dependent conductances and synaptic transmission, resulting in state-dependent modulation of target cells. These studies make clear predictions about how dopamine, particularly via D1 receptor activation, should alter the responsiveness of striatal neurons to extrinsic excitatory synaptic activity.</description><identifier>ISSN: 0147-006X</identifier><identifier>EISSN: 1545-4126</identifier><identifier>DOI: 10.1146/annurev.neuro.23.1.185</identifier><identifier>PMID: 10845063</identifier><identifier>CODEN: ARNSD5</identifier><language>eng</language><publisher>Palo Alto, CA: Annual Reviews</publisher><subject>Anesthesia ; Animals ; Biological and medical sciences ; Central nervous system ; Corpus Striatum - cytology ; Corpus Striatum - physiology ; Dopamine - physiology ; Electric Conductivity ; Electrophysiology ; Fundamental and applied biological sciences. Psychology ; Humans ; Ions ; Neurons - physiology ; Nucleus Accumbens - physiology ; Receptors, Dopamine - metabolism ; Synaptic Transmission - physiology ; Vertebrates: nervous system and sense organs ; Wakefulness - physiology</subject><ispartof>Annual review of neuroscience, 2000-01, Vol.23 (1), p.185-215</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright Annual Reviews, Inc. 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-eb15174ec78262996756cca96afee628e94984fe8f25cc0b31cf8c342a8ac1673</citedby><cites>FETCH-LOGICAL-c462t-eb15174ec78262996756cca96afee628e94984fe8f25cc0b31cf8c342a8ac1673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,4170,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1352329$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10845063$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NICOLA, S. M</creatorcontrib><creatorcontrib>SURMEIER, D. J</creatorcontrib><creatorcontrib>MALENKA, R. C</creatorcontrib><title>Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens</title><title>Annual review of neuroscience</title><addtitle>Annu Rev Neurosci</addtitle><description>The striatum and its ventral extension, the nucleus accumbens, are involved in behaviors as diverse as motor planning, drug seeking, and learning. Invariably, these striatally mediated behaviors depend on intact dopaminergic innervation. However, the mechanisms by which dopamine modulates neuronal function in the striatum and nucleus accumbens have been difficult to elucidate. Recent electrophysiological studies have revealed that dopamine alters both voltage-dependent conductances and synaptic transmission, resulting in state-dependent modulation of target cells. These studies make clear predictions about how dopamine, particularly via D1 receptor activation, should alter the responsiveness of striatal neurons to extrinsic excitatory synaptic activity.</description><subject>Anesthesia</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Corpus Striatum - cytology</subject><subject>Corpus Striatum - physiology</subject><subject>Dopamine - physiology</subject><subject>Electric Conductivity</subject><subject>Electrophysiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Ions</subject><subject>Neurons - physiology</subject><subject>Nucleus Accumbens - physiology</subject><subject>Receptors, Dopamine - metabolism</subject><subject>Synaptic Transmission - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Wakefulness - physiology</subject><issn>0147-006X</issn><issn>1545-4126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0Utv1DAUBWALgehQ-AuVhRC7BL9jL1HLS6rEBhA768ZzA64Se7BjRP89aWckEBtWd_PdsziHkAvOes6VeQUptYI_-4St5F7Invfc6gdkx7XSneLCPCQ7xtXQMWa-npEntd4wxpyU7jE548wqzYzckS9X-QBLTFi-xUCXvG8zrDEnmid6n51gpvgrxBXGOMf1lsZE1-9I61oirG2hkPY0tTBjqxRCaMuIqT4ljyaYKz473XPy-e2bT5fvu-uP7z5cvr7ugjJi7XDkmg8Kw2CFEc6ZQZsQwBmYEI2w6JSzakI7CR0CGyUPkw1SCbAQuBnkOXl5zD2U_KNhXf0Sa8B5hoS5VT_wTSnj_gv5oOUghN7g83_gTW5la2Ezzlo7aHWXZo4olFxrwckfSlyg3HrO_N0-_rSPv-_QC-m53_bZHi9O6W1ccP_X23GQDbw4AagB5qlACrH-cVILKZz8DTKSnas</recordid><startdate>20000101</startdate><enddate>20000101</enddate><creator>NICOLA, S. M</creator><creator>SURMEIER, D. J</creator><creator>MALENKA, R. C</creator><general>Annual Reviews</general><general>Annual Reviews, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PADUT</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20000101</creationdate><title>Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens</title><author>NICOLA, S. M ; SURMEIER, D. J ; MALENKA, R. C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-eb15174ec78262996756cca96afee628e94984fe8f25cc0b31cf8c342a8ac1673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Anesthesia</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Corpus Striatum - cytology</topic><topic>Corpus Striatum - physiology</topic><topic>Dopamine - physiology</topic><topic>Electric Conductivity</topic><topic>Electrophysiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Ions</topic><topic>Neurons - physiology</topic><topic>Nucleus Accumbens - physiology</topic><topic>Receptors, Dopamine - metabolism</topic><topic>Synaptic Transmission - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Wakefulness - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NICOLA, S. M</creatorcontrib><creatorcontrib>SURMEIER, D. J</creatorcontrib><creatorcontrib>MALENKA, R. C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database (ProQuest)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Research Library China</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Annual review of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NICOLA, S. M</au><au>SURMEIER, D. J</au><au>MALENKA, R. C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens</atitle><jtitle>Annual review of neuroscience</jtitle><addtitle>Annu Rev Neurosci</addtitle><date>2000-01-01</date><risdate>2000</risdate><volume>23</volume><issue>1</issue><spage>185</spage><epage>215</epage><pages>185-215</pages><issn>0147-006X</issn><eissn>1545-4126</eissn><coden>ARNSD5</coden><abstract>The striatum and its ventral extension, the nucleus accumbens, are involved in behaviors as diverse as motor planning, drug seeking, and learning. Invariably, these striatally mediated behaviors depend on intact dopaminergic innervation. However, the mechanisms by which dopamine modulates neuronal function in the striatum and nucleus accumbens have been difficult to elucidate. Recent electrophysiological studies have revealed that dopamine alters both voltage-dependent conductances and synaptic transmission, resulting in state-dependent modulation of target cells. These studies make clear predictions about how dopamine, particularly via D1 receptor activation, should alter the responsiveness of striatal neurons to extrinsic excitatory synaptic activity.</abstract><cop>Palo Alto, CA</cop><pub>Annual Reviews</pub><pmid>10845063</pmid><doi>10.1146/annurev.neuro.23.1.185</doi><tpages>31</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0147-006X |
| ispartof | Annual review of neuroscience, 2000-01, Vol.23 (1), p.185-215 |
| issn | 0147-006X 1545-4126 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71167469 |
| source | Annual Reviews Complete A-Z List; MEDLINE |
| subjects | Anesthesia Animals Biological and medical sciences Central nervous system Corpus Striatum - cytology Corpus Striatum - physiology Dopamine - physiology Electric Conductivity Electrophysiology Fundamental and applied biological sciences. Psychology Humans Ions Neurons - physiology Nucleus Accumbens - physiology Receptors, Dopamine - metabolism Synaptic Transmission - physiology Vertebrates: nervous system and sense organs Wakefulness - physiology |
| title | Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T12%3A20%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dopaminergic%20modulation%20of%20neuronal%20excitability%20in%20the%20striatum%20and%20nucleus%20accumbens&rft.jtitle=Annual%20review%20of%20neuroscience&rft.au=NICOLA,%20S.%20M&rft.date=2000-01-01&rft.volume=23&rft.issue=1&rft.spage=185&rft.epage=215&rft.pages=185-215&rft.issn=0147-006X&rft.eissn=1545-4126&rft.coden=ARNSD5&rft_id=info:doi/10.1146/annurev.neuro.23.1.185&rft_dat=%3Cproquest_cross%3E54142182%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=198887549&rft_id=info:pmid/10845063&rfr_iscdi=true |