Preparation and characterisation of a range of diclofenac salts

Physicochemical properties of diclofenac salts prepared using eight different counterions and including five novel salts, obtained with the bases 2-amino-2-methyl-1,3-propanediol, 2-amino-2-methylpropanol, tert-butylamine, benzylamine and deanol, were compared. Four of the bases used to prepare thes...

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Veröffentlicht in:	International journal of pharmaceutics 2001-09, Vol.226 (1), p.163-179
Hauptverfasser:	O'Connor, Karen M, Corrigan, Owen I
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Amino-2-methyl-1,3-propanediol 2-Amino-2-methylpropanol Anti-Inflammatory Agents, Non-Steroidal - chemistry Benzylamine Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Chemistry, Pharmaceutical Diclofenac Diclofenac - chemistry General pharmacology Hydrogen-Ion Concentration Medical sciences Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Salts Solubility Structure-Activity Relationship tert-Butylamine Tris(hydroxymethyl)aminomethane
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