Antinociceptive effect of the essential oil from Cymbopogon citratus in mice
The essential oil (EO) from leaves of Cymbopogon citratus increased the reaction time to thermal stimuli both after oral (25 mg/kg) and intraperitoneal (25–100 mg/kg) administration. EO (50–200 mg/kg, p.o. or i.p.) strongly inhibited the acetic acid-induced writhings in mice. In the formalin test, E...
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| Veröffentlicht in: | Journal of ethnopharmacology 2000-06, Vol.70 (3), p.323-327 |
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| container_title | Journal of ethnopharmacology |
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| creator | Viana, G.S.B Vale, T.G Pinho, R.S.N Matos, F.J.A |
| description | The essential oil (EO) from leaves of
Cymbopogon citratus increased the reaction time to thermal stimuli both after oral (25 mg/kg) and intraperitoneal (25–100 mg/kg) administration. EO (50–200 mg/kg, p.o. or i.p.) strongly inhibited the acetic acid-induced writhings in mice. In the formalin test, EO (50 and 200 mg/kg, i.p.) inhibited preferentially the second phase of the response, causing inhibitions of 100 and 48% at 200 mg/kg, i.p. and 100 mg/kg, p.o., respectively. On the other hand, the opioid antagonist naloxone blocked the central antinociceptive effect of EO, suggesting that EO acts both at peripheral and central levels. |
| doi_str_mv | 10.1016/S0378-8741(99)00168-3 |
| format | Article |
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Cymbopogon citratus increased the reaction time to thermal stimuli both after oral (25 mg/kg) and intraperitoneal (25–100 mg/kg) administration. EO (50–200 mg/kg, p.o. or i.p.) strongly inhibited the acetic acid-induced writhings in mice. In the formalin test, EO (50 and 200 mg/kg, i.p.) inhibited preferentially the second phase of the response, causing inhibitions of 100 and 48% at 200 mg/kg, i.p. and 100 mg/kg, p.o., respectively. On the other hand, the opioid antagonist naloxone blocked the central antinociceptive effect of EO, suggesting that EO acts both at peripheral and central levels.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/S0378-8741(99)00168-3</identifier><identifier>PMID: 10837994</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Acetates ; Analgesics - antagonists & inhibitors ; Analgesics - isolation & purification ; Analgesics - pharmacology ; Animals ; Antinociceptive activity ; Behavior, Animal - drug effects ; Caribbean Region ; Chromatography, Gas ; Cymbopogon citratus ; Essential oil ; Formaldehyde ; human health and safety ; Male ; Mass Spectrometry ; medicine ; Mice ; Naloxone - pharmacology ; Narcotic Antagonists - pharmacology ; nonfood plant products ; Oils, Volatile - isolation & purification ; Oils, Volatile - pharmacology ; Pain Measurement - drug effects ; Plant Leaves - chemistry ; Plants, Medicinal - chemistry ; Poaceae - chemistry ; Reaction Time - drug effects</subject><ispartof>Journal of ethnopharmacology, 2000-06, Vol.70 (3), p.323-327</ispartof><rights>2000 Elsevier Science Ireland Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-d32437b0b047422130bf71a8255192bf46dbbbbac588cb2f2492a634bd2855c13</citedby><cites>FETCH-LOGICAL-c451t-d32437b0b047422130bf71a8255192bf46dbbbbac588cb2f2492a634bd2855c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378874199001683$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10837994$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Viana, G.S.B</creatorcontrib><creatorcontrib>Vale, T.G</creatorcontrib><creatorcontrib>Pinho, R.S.N</creatorcontrib><creatorcontrib>Matos, F.J.A</creatorcontrib><title>Antinociceptive effect of the essential oil from Cymbopogon citratus in mice</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>The essential oil (EO) from leaves of
Cymbopogon citratus increased the reaction time to thermal stimuli both after oral (25 mg/kg) and intraperitoneal (25–100 mg/kg) administration. EO (50–200 mg/kg, p.o. or i.p.) strongly inhibited the acetic acid-induced writhings in mice. In the formalin test, EO (50 and 200 mg/kg, i.p.) inhibited preferentially the second phase of the response, causing inhibitions of 100 and 48% at 200 mg/kg, i.p. and 100 mg/kg, p.o., respectively. 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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acetates Analgesics - antagonists & inhibitors Analgesics - isolation & purification Analgesics - pharmacology Animals Antinociceptive activity Behavior, Animal - drug effects Caribbean Region Chromatography, Gas Cymbopogon citratus Essential oil Formaldehyde human health and safety Male Mass Spectrometry medicine Mice Naloxone - pharmacology Narcotic Antagonists - pharmacology nonfood plant products Oils, Volatile - isolation & purification Oils, Volatile - pharmacology Pain Measurement - drug effects Plant Leaves - chemistry Plants, Medicinal - chemistry Poaceae - chemistry Reaction Time - drug effects |
| title | Antinociceptive effect of the essential oil from Cymbopogon citratus in mice |
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