Transient increase in mitogen-induced lymphoproliferative responses in patients with testicular cancer after BEP chemotherapy
Objectives. To investigate the impact of polychemotherapy on cellular immunity in patients with testicular cancer. Methods. Lymphocyte subpopulations, lymphoproliferative responses to mitogenic stimulation, and mitogen-induced release of soluble interleukin-2 receptor from peripheral blood mononucle...
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| Veröffentlicht in: | Urology (Ridgewood, N.J.) N.J.), 2000-06, Vol.55 (6), p.934-938 |
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| container_title | Urology (Ridgewood, N.J.) |
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| creator | Krainer, Michael Wolf, Hermann M Wiltschke, Christoph Wilfing, Astrid Kaider, Alexandra Kratzik, Christian Eibl, Martha M Zielinski, Christoph C |
| description | Objectives. To investigate the impact of polychemotherapy on cellular immunity in patients with testicular cancer.
Methods. Lymphocyte subpopulations, lymphoproliferative responses to mitogenic stimulation, and mitogen-induced release of soluble interleukin-2 receptor from peripheral blood mononuclear cells were investigated in 15 patients with testicular germ cell tumors a median of 61 months (range 7 to 73) after polychemotherapy with bleomycin, etoposide, and cisplatin (BEP).
Results. The numbers of peripheral blood T cells (CD3+), CD4+ and CD8+ subsets, and lymphoproliferative responses to pokeweed mitogen, phytohemagglutinin, and concanavalin A in patients were comparable to those of healthy control subjects. When two groups of patients were formed according to elapsed time from BEP polychemotherapy and study onset (group A, 12 months and group B, 69 months after termination of BEP), a significant increase in lymphoproliferative response to concanavalin A (
P |
| doi_str_mv | 10.1016/S0090-4295(00)00524-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71164288</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0090429500005240</els_id><sourcerecordid>71164288</sourcerecordid><originalsourceid>FETCH-LOGICAL-c390t-5429c68979cbdf801d09aa490f495ba98d95e7a2124f4e0a5456ec36676ea1bd3</originalsourceid><addsrcrecordid>eNqFkU1v1DAQhi0EokvhJ4B8QAgOKeOsncQnBFWBSpVAopwtrzNhjfKFxynaA_-d2e6q5cbFtqxnxvM-FuK5gjMFqnr7DcBCoUtrXgO8ATClLuCBWClT1oW11jwUqzvkRDwh-gkAVVXVj8WJgkaDUuuV-HOd_EgRxyzjGBJ6Qj7IIebpB45FHNslYCv73TBvpzlNfeww-RxvUCakeRoJaV8w8x03Ifk75q3MSDmGpfdJBj8GTNJ3mdcPF19l2OIw5S13mXdPxaPO94TPjvup-P7x4vr8c3H15dPl-furIqwt5MJwhlA1trZh03YNqBas99pCp63ZeNu01mDtS1XqTiN4o02FYc1ZK_Rq065PxatDX07wa-Hh3BApYN_7EaeFXK1UpcumYdAcwJAmooSdm1McfNo5BW7v3d16d3upDsDdenfAdS-ODyybAdt_qg6iGXh5BDwF33dsPUS65zQY0xjG3h0wZBs3EZOjwF75C2LCkF07xf9M8hdODaG_</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71164288</pqid></control><display><type>article</type><title>Transient increase in mitogen-induced lymphoproliferative responses in patients with testicular cancer after BEP chemotherapy</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Krainer, Michael ; Wolf, Hermann M ; Wiltschke, Christoph ; Wilfing, Astrid ; Kaider, Alexandra ; Kratzik, Christian ; Eibl, Martha M ; Zielinski, Christoph C</creator><creatorcontrib>Krainer, Michael ; Wolf, Hermann M ; Wiltschke, Christoph ; Wilfing, Astrid ; Kaider, Alexandra ; Kratzik, Christian ; Eibl, Martha M ; Zielinski, Christoph C</creatorcontrib><description>Objectives. To investigate the impact of polychemotherapy on cellular immunity in patients with testicular cancer.
Methods. Lymphocyte subpopulations, lymphoproliferative responses to mitogenic stimulation, and mitogen-induced release of soluble interleukin-2 receptor from peripheral blood mononuclear cells were investigated in 15 patients with testicular germ cell tumors a median of 61 months (range 7 to 73) after polychemotherapy with bleomycin, etoposide, and cisplatin (BEP).
Results. The numbers of peripheral blood T cells (CD3+), CD4+ and CD8+ subsets, and lymphoproliferative responses to pokeweed mitogen, phytohemagglutinin, and concanavalin A in patients were comparable to those of healthy control subjects. When two groups of patients were formed according to elapsed time from BEP polychemotherapy and study onset (group A, 12 months and group B, 69 months after termination of BEP), a significant increase in lymphoproliferative response to concanavalin A (
P <0.05) was found in group A 1 year after chemotherapy.
Conclusions. BEP chemotherapy administered to patients with testicular cancer does not result in impairment of cellular immunity but rather leads to a significant increase in the capacity of patients’ lymphocytes to respond to mitogenic stimulation up to 1 year after polychemotherapy. Moreover, the increased T-cell activity found after BEP therapy may contribute to the high rate of long-term complete remission.</description><identifier>ISSN: 0090-4295</identifier><identifier>EISSN: 1527-9995</identifier><identifier>DOI: 10.1016/S0090-4295(00)00524-0</identifier><identifier>PMID: 10840113</identifier><identifier>CODEN: URGYAZ</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biological and medical sciences ; Bleomycin - administration & dosage ; Cisplatin - administration & dosage ; Concanavalin A ; Etoposide - administration & dosage ; Germinoma - drug therapy ; Germinoma - immunology ; Gynecology. Andrology. Obstetrics ; Humans ; Immunity, Cellular ; Lectins ; Leukocytes, Mononuclear ; Lymphocyte Activation ; Male ; Male genital diseases ; Medical sciences ; Receptors, Interleukin-2 ; Testicular Neoplasms - drug therapy ; Testicular Neoplasms - immunology ; Tumors</subject><ispartof>Urology (Ridgewood, N.J.), 2000-06, Vol.55 (6), p.934-938</ispartof><rights>2000 Elsevier Science Inc.</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-5429c68979cbdf801d09aa490f495ba98d95e7a2124f4e0a5456ec36676ea1bd3</citedby><cites>FETCH-LOGICAL-c390t-5429c68979cbdf801d09aa490f495ba98d95e7a2124f4e0a5456ec36676ea1bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0090-4295(00)00524-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1405585$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10840113$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krainer, Michael</creatorcontrib><creatorcontrib>Wolf, Hermann M</creatorcontrib><creatorcontrib>Wiltschke, Christoph</creatorcontrib><creatorcontrib>Wilfing, Astrid</creatorcontrib><creatorcontrib>Kaider, Alexandra</creatorcontrib><creatorcontrib>Kratzik, Christian</creatorcontrib><creatorcontrib>Eibl, Martha M</creatorcontrib><creatorcontrib>Zielinski, Christoph C</creatorcontrib><title>Transient increase in mitogen-induced lymphoproliferative responses in patients with testicular cancer after BEP chemotherapy</title><title>Urology (Ridgewood, N.J.)</title><addtitle>Urology</addtitle><description>Objectives. To investigate the impact of polychemotherapy on cellular immunity in patients with testicular cancer.
Methods. Lymphocyte subpopulations, lymphoproliferative responses to mitogenic stimulation, and mitogen-induced release of soluble interleukin-2 receptor from peripheral blood mononuclear cells were investigated in 15 patients with testicular germ cell tumors a median of 61 months (range 7 to 73) after polychemotherapy with bleomycin, etoposide, and cisplatin (BEP).
Results. The numbers of peripheral blood T cells (CD3+), CD4+ and CD8+ subsets, and lymphoproliferative responses to pokeweed mitogen, phytohemagglutinin, and concanavalin A in patients were comparable to those of healthy control subjects. When two groups of patients were formed according to elapsed time from BEP polychemotherapy and study onset (group A, 12 months and group B, 69 months after termination of BEP), a significant increase in lymphoproliferative response to concanavalin A (
P <0.05) was found in group A 1 year after chemotherapy.
Conclusions. BEP chemotherapy administered to patients with testicular cancer does not result in impairment of cellular immunity but rather leads to a significant increase in the capacity of patients’ lymphocytes to respond to mitogenic stimulation up to 1 year after polychemotherapy. Moreover, the increased T-cell activity found after BEP therapy may contribute to the high rate of long-term complete remission.</description><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Bleomycin - administration & dosage</subject><subject>Cisplatin - administration & dosage</subject><subject>Concanavalin A</subject><subject>Etoposide - administration & dosage</subject><subject>Germinoma - drug therapy</subject><subject>Germinoma - immunology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Immunity, Cellular</subject><subject>Lectins</subject><subject>Leukocytes, Mononuclear</subject><subject>Lymphocyte Activation</subject><subject>Male</subject><subject>Male genital diseases</subject><subject>Medical sciences</subject><subject>Receptors, Interleukin-2</subject><subject>Testicular Neoplasms - drug therapy</subject><subject>Testicular Neoplasms - immunology</subject><subject>Tumors</subject><issn>0090-4295</issn><issn>1527-9995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EokvhJ4B8QAgOKeOsncQnBFWBSpVAopwtrzNhjfKFxynaA_-d2e6q5cbFtqxnxvM-FuK5gjMFqnr7DcBCoUtrXgO8ATClLuCBWClT1oW11jwUqzvkRDwh-gkAVVXVj8WJgkaDUuuV-HOd_EgRxyzjGBJ6Qj7IIebpB45FHNslYCv73TBvpzlNfeww-RxvUCakeRoJaV8w8x03Ifk75q3MSDmGpfdJBj8GTNJ3mdcPF19l2OIw5S13mXdPxaPO94TPjvup-P7x4vr8c3H15dPl-furIqwt5MJwhlA1trZh03YNqBas99pCp63ZeNu01mDtS1XqTiN4o02FYc1ZK_Rq065PxatDX07wa-Hh3BApYN_7EaeFXK1UpcumYdAcwJAmooSdm1McfNo5BW7v3d16d3upDsDdenfAdS-ODyybAdt_qg6iGXh5BDwF33dsPUS65zQY0xjG3h0wZBs3EZOjwF75C2LCkF07xf9M8hdODaG_</recordid><startdate>20000601</startdate><enddate>20000601</enddate><creator>Krainer, Michael</creator><creator>Wolf, Hermann M</creator><creator>Wiltschke, Christoph</creator><creator>Wilfing, Astrid</creator><creator>Kaider, Alexandra</creator><creator>Kratzik, Christian</creator><creator>Eibl, Martha M</creator><creator>Zielinski, Christoph C</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000601</creationdate><title>Transient increase in mitogen-induced lymphoproliferative responses in patients with testicular cancer after BEP chemotherapy</title><author>Krainer, Michael ; Wolf, Hermann M ; Wiltschke, Christoph ; Wilfing, Astrid ; Kaider, Alexandra ; Kratzik, Christian ; Eibl, Martha M ; Zielinski, Christoph C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-5429c68979cbdf801d09aa490f495ba98d95e7a2124f4e0a5456ec36676ea1bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Bleomycin - administration & dosage</topic><topic>Cisplatin - administration & dosage</topic><topic>Concanavalin A</topic><topic>Etoposide - administration & dosage</topic><topic>Germinoma - drug therapy</topic><topic>Germinoma - immunology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Immunity, Cellular</topic><topic>Lectins</topic><topic>Leukocytes, Mononuclear</topic><topic>Lymphocyte Activation</topic><topic>Male</topic><topic>Male genital diseases</topic><topic>Medical sciences</topic><topic>Receptors, Interleukin-2</topic><topic>Testicular Neoplasms - drug therapy</topic><topic>Testicular Neoplasms - immunology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Krainer, Michael</creatorcontrib><creatorcontrib>Wolf, Hermann M</creatorcontrib><creatorcontrib>Wiltschke, Christoph</creatorcontrib><creatorcontrib>Wilfing, Astrid</creatorcontrib><creatorcontrib>Kaider, Alexandra</creatorcontrib><creatorcontrib>Kratzik, Christian</creatorcontrib><creatorcontrib>Eibl, Martha M</creatorcontrib><creatorcontrib>Zielinski, Christoph C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Urology (Ridgewood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Krainer, Michael</au><au>Wolf, Hermann M</au><au>Wiltschke, Christoph</au><au>Wilfing, Astrid</au><au>Kaider, Alexandra</au><au>Kratzik, Christian</au><au>Eibl, Martha M</au><au>Zielinski, Christoph C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transient increase in mitogen-induced lymphoproliferative responses in patients with testicular cancer after BEP chemotherapy</atitle><jtitle>Urology (Ridgewood, N.J.)</jtitle><addtitle>Urology</addtitle><date>2000-06-01</date><risdate>2000</risdate><volume>55</volume><issue>6</issue><spage>934</spage><epage>938</epage><pages>934-938</pages><issn>0090-4295</issn><eissn>1527-9995</eissn><coden>URGYAZ</coden><abstract>Objectives. To investigate the impact of polychemotherapy on cellular immunity in patients with testicular cancer.
Methods. Lymphocyte subpopulations, lymphoproliferative responses to mitogenic stimulation, and mitogen-induced release of soluble interleukin-2 receptor from peripheral blood mononuclear cells were investigated in 15 patients with testicular germ cell tumors a median of 61 months (range 7 to 73) after polychemotherapy with bleomycin, etoposide, and cisplatin (BEP).
Results. The numbers of peripheral blood T cells (CD3+), CD4+ and CD8+ subsets, and lymphoproliferative responses to pokeweed mitogen, phytohemagglutinin, and concanavalin A in patients were comparable to those of healthy control subjects. When two groups of patients were formed according to elapsed time from BEP polychemotherapy and study onset (group A, 12 months and group B, 69 months after termination of BEP), a significant increase in lymphoproliferative response to concanavalin A (
P <0.05) was found in group A 1 year after chemotherapy.
Conclusions. BEP chemotherapy administered to patients with testicular cancer does not result in impairment of cellular immunity but rather leads to a significant increase in the capacity of patients’ lymphocytes to respond to mitogenic stimulation up to 1 year after polychemotherapy. Moreover, the increased T-cell activity found after BEP therapy may contribute to the high rate of long-term complete remission.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10840113</pmid><doi>10.1016/S0090-4295(00)00524-0</doi><tpages>5</tpages></addata></record> |
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| subjects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Bleomycin - administration & dosage Cisplatin - administration & dosage Concanavalin A Etoposide - administration & dosage Germinoma - drug therapy Germinoma - immunology Gynecology. Andrology. Obstetrics Humans Immunity, Cellular Lectins Leukocytes, Mononuclear Lymphocyte Activation Male Male genital diseases Medical sciences Receptors, Interleukin-2 Testicular Neoplasms - drug therapy Testicular Neoplasms - immunology Tumors |
| title | Transient increase in mitogen-induced lymphoproliferative responses in patients with testicular cancer after BEP chemotherapy |
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