Induction of cell proliferation arrest and apoptosis in hepatoma cells through adenoviral-mediated transfer of p53 gene

Background/Aim: Loss of p53 function is common in hepatocellular carcinoma and is associated with an extremely poor prognosis. The aim of the study was to evaluate the biologic effect of adenoviral-mediated gene transfer of wild-type p53 gene in four hepatoma cell lines with different p53 genetic ma...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of hepatology 2000-05, Vol.32 (5), p.771-782
Hauptverfasser:	Reiser, Markus, Neumann, Ilka, Schmiegel, Wolff, Wu, Pui-Chee, Lau, Johnson Y.N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae Adenovirus replication Apoptosis - genetics Bax Biological and medical sciences Biotechnology Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Cell Division - genetics Fundamental and applied biological sciences. Psychology Gene delivery Gene Expression Regulation, Neoplastic Gene therapy Gene Transfer Techniques Genes, p53 Genetic Vectors Health. Pharmaceutical industry Hep3B HepG2 Huh-7 Humans Industrial applications and implications. Economical aspects Liver Neoplasms - genetics Liver Neoplasms - pathology Mahlavu p21 p53 Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!