Outbreak of ampicillin-resistant Enterococcus faecium: risk factors for faecal colonisation
Since January 1995 there has been a nosocomial outbreak at Haukeland University Hospital involving more than 330 patients with clinical infections caused by ampicillin‐resistant Enterococcus faecium (ARE) (minimum inhibitory concentration ≥32 mg/l). Rectal carriage of ARE was initially observed on t...
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| Veröffentlicht in: | APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 2000-04, Vol.108 (4), p.296-302 |
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| container_title | APMIS : acta pathologica, microbiologica et immunologica Scandinavica |
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| creator | Mohn, S.C. (Haukeland Sykehus (Bergen)) Harthug, S Langeland, N |
| description | Since January 1995 there has been a nosocomial outbreak at Haukeland University Hospital involving more than 330 patients with clinical infections caused by ampicillin‐resistant Enterococcus faecium (ARE) (minimum inhibitory concentration ≥32 mg/l). Rectal carriage of ARE was initially observed on two medical wards only. Here the ARE colonisation rate has remained high. To assess risk factors for ARE colonisation we performed a case‐control study including 37 rectal carriers of ARE and 83 non‐carriers on these wards. Significant differences were found between cases and controls with respect to the mean number of days on antimicrobial treatment (13.3 for carriers, 5.5 for non‐carriers, p |
| doi_str_mv | 10.1034/j.1600-0463.2000.d01-60.x |
| format | Article |
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(Haukeland Sykehus (Bergen)) ; Harthug, S ; Langeland, N</creator><creatorcontrib>Mohn, S.C. (Haukeland Sykehus (Bergen)) ; Harthug, S ; Langeland, N</creatorcontrib><description>Since January 1995 there has been a nosocomial outbreak at Haukeland University Hospital involving more than 330 patients with clinical infections caused by ampicillin‐resistant Enterococcus faecium (ARE) (minimum inhibitory concentration ≥32 mg/l). Rectal carriage of ARE was initially observed on two medical wards only. Here the ARE colonisation rate has remained high. To assess risk factors for ARE colonisation we performed a case‐control study including 37 rectal carriers of ARE and 83 non‐carriers on these wards. Significant differences were found between cases and controls with respect to the mean number of days on antimicrobial treatment (13.3 for carriers, 5.5 for non‐carriers, p<0.001), mean number of different antibiotics prescribed (2.8 for carriers, 2.1 for non‐carriers, p=0.008) and mean number of days in hospital (18.4 vs 10.2, p=0.001). Unadjusted statistical analysis showed that several antibiotics were risk factors for ARE carriage. Logistic regression analysis showed that fluoroquinolone prescription (OR=3.5, p=0.01) and more than 10 days of antibiotic use (OR=3.3, p=0.01) were significant risk factors. An additional follow‐up screening of previous carriers revealed no colonisation 8 to 36 (median 9) months after discharge from hospital (n=17). Prolonged antimicrobial therapy and broad‐spectrum antibiotics seem to facilitate nosocomial ARE colonisation.</description><identifier>ISSN: 0903-4641</identifier><identifier>EISSN: 1600-0463</identifier><identifier>DOI: 10.1034/j.1600-0463.2000.d01-60.x</identifier><identifier>PMID: 10843419</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Ampicillin Resistance ; Analysis of Variance ; Anti-Bacterial Agents - therapeutic use ; APTITUD COLONIZADORA ; APTITUDE A COLONISER ; Bacterial diseases ; Bacterial diseases of the digestive system and abdomen ; Bacteriology ; Biological and medical sciences ; Carrier State - epidemiology ; Case-Control Studies ; colonisation ; COLONIZING ABILITY ; Cross Infection - drug therapy ; Cross Infection - epidemiology ; Cross Infection - transmission ; Disease Outbreaks ; Enterococci ; Enterococcus faecium - isolation & purification ; Epidemiology ; Feces - microbiology ; Fundamental and applied biological sciences. Psychology ; Gram-Positive Bacterial Infections - drug therapy ; Gram-Positive Bacterial Infections - epidemiology ; Gram-Positive Bacterial Infections - transmission ; Hospital Bed Capacity, 500 and over ; Hospitals, University ; Human bacterial diseases ; Humans ; Infectious diseases ; Length of Stay ; Medical sciences ; Microbiology ; Norway - epidemiology ; PENICILINA ; PENICILLINE ; PENICILLINS ; Prevalence ; Regression Analysis ; RESISTANCE AUX PRODUITS CHIMIQUES ; RESISTANCE TO CHEMICALS ; RESISTENCIA A PRODUCTOS QUIMICOS ; Risk Factors ; STREPTOCOCCUS FAECIUM</subject><ispartof>APMIS : acta pathologica, microbiologica et immunologica Scandinavica, 2000-04, Vol.108 (4), p.296-302</ispartof><rights>2000 APMIS</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4566-9e878619c465fa687bf9f2dc403e5f3b61b31e4f8ee244e4adbc577e948116203</citedby><cites>FETCH-LOGICAL-c4566-9e878619c465fa687bf9f2dc403e5f3b61b31e4f8ee244e4adbc577e948116203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1034%2Fj.1600-0463.2000.d01-60.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1034%2Fj.1600-0463.2000.d01-60.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1412716$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10843419$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mohn, S.C. (Haukeland Sykehus (Bergen))</creatorcontrib><creatorcontrib>Harthug, S</creatorcontrib><creatorcontrib>Langeland, N</creatorcontrib><title>Outbreak of ampicillin-resistant Enterococcus faecium: risk factors for faecal colonisation</title><title>APMIS : acta pathologica, microbiologica et immunologica Scandinavica</title><addtitle>APMIS</addtitle><description>Since January 1995 there has been a nosocomial outbreak at Haukeland University Hospital involving more than 330 patients with clinical infections caused by ampicillin‐resistant Enterococcus faecium (ARE) (minimum inhibitory concentration ≥32 mg/l). Rectal carriage of ARE was initially observed on two medical wards only. Here the ARE colonisation rate has remained high. To assess risk factors for ARE colonisation we performed a case‐control study including 37 rectal carriers of ARE and 83 non‐carriers on these wards. Significant differences were found between cases and controls with respect to the mean number of days on antimicrobial treatment (13.3 for carriers, 5.5 for non‐carriers, p<0.001), mean number of different antibiotics prescribed (2.8 for carriers, 2.1 for non‐carriers, p=0.008) and mean number of days in hospital (18.4 vs 10.2, p=0.001). Unadjusted statistical analysis showed that several antibiotics were risk factors for ARE carriage. Logistic regression analysis showed that fluoroquinolone prescription (OR=3.5, p=0.01) and more than 10 days of antibiotic use (OR=3.3, p=0.01) were significant risk factors. An additional follow‐up screening of previous carriers revealed no colonisation 8 to 36 (median 9) months after discharge from hospital (n=17). Prolonged antimicrobial therapy and broad‐spectrum antibiotics seem to facilitate nosocomial ARE colonisation.</description><subject>Ampicillin Resistance</subject><subject>Analysis of Variance</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>APTITUD COLONIZADORA</subject><subject>APTITUDE A COLONISER</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the digestive system and abdomen</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Carrier State - epidemiology</subject><subject>Case-Control Studies</subject><subject>colonisation</subject><subject>COLONIZING ABILITY</subject><subject>Cross Infection - drug therapy</subject><subject>Cross Infection - epidemiology</subject><subject>Cross Infection - transmission</subject><subject>Disease Outbreaks</subject><subject>Enterococci</subject><subject>Enterococcus faecium - isolation & purification</subject><subject>Epidemiology</subject><subject>Feces - microbiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gram-Positive Bacterial Infections - drug therapy</subject><subject>Gram-Positive Bacterial Infections - epidemiology</subject><subject>Gram-Positive Bacterial Infections - transmission</subject><subject>Hospital Bed Capacity, 500 and over</subject><subject>Hospitals, University</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Length of Stay</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Norway - epidemiology</subject><subject>PENICILINA</subject><subject>PENICILLINE</subject><subject>PENICILLINS</subject><subject>Prevalence</subject><subject>Regression Analysis</subject><subject>RESISTANCE AUX PRODUITS CHIMIQUES</subject><subject>RESISTANCE TO CHEMICALS</subject><subject>RESISTENCIA A PRODUCTOS QUIMICOS</subject><subject>Risk Factors</subject><subject>STREPTOCOCCUS FAECIUM</subject><issn>0903-4641</issn><issn>1600-0463</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFu1DAQhi0EotuWRwAFCfWWYMeOHSNxqLaloJYWKIgDB8vxjpF3k3hrJ2L79jhkVTjii2XP94-tbxB6SXBBMGWv1wXhGOeYcVqUGONihUnOcbF7hBYPlcdogSWmOeOMHKDDGNcYk7Lm4ik6ILhmlBG5QD9uxqEJoDeZt5nuts64tnV9HiC6OOh-yM77AYI33pgxZlaDcWP3JgsubtLJDD6kWx_-VHSbGd_63kU9ON8foydWtxGe7fcj9O3d-dfl-_zq5uLD8vQqN6ziPJdQi5oTaRivrOa1aKy05cowTKGytOGkoQSYrQFKxoDpVWMqIUCymhBeYnqETua-2-DvRoiD6lw00La6Bz9GJQipZFXTBMoZNMHHGMCqbXCdDveKYDWZVWs1-VOTPzWZVcms4ljtUvbF_pGx6WD1T3JWmYBXe0DHZMIG3RsX_3KMlILwhL2dsV-uhfv__4A6_fSxlFM-n_NpPLB7yOuwUVxQUanv1xeqvpT88-3yi7pN_POZt9or_TPNTZ1dTp3TkqKkvwEDrK0W</recordid><startdate>20000401</startdate><enddate>20000401</enddate><creator>Mohn, S.C. (Haukeland Sykehus (Bergen))</creator><creator>Harthug, S</creator><creator>Langeland, N</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000401</creationdate><title>Outbreak of ampicillin-resistant Enterococcus faecium: risk factors for faecal colonisation</title><author>Mohn, S.C. (Haukeland Sykehus (Bergen)) ; Harthug, S ; Langeland, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4566-9e878619c465fa687bf9f2dc403e5f3b61b31e4f8ee244e4adbc577e948116203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Ampicillin Resistance</topic><topic>Analysis of Variance</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>APTITUD COLONIZADORA</topic><topic>APTITUDE A COLONISER</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the digestive system and abdomen</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Carrier State - epidemiology</topic><topic>Case-Control Studies</topic><topic>colonisation</topic><topic>COLONIZING ABILITY</topic><topic>Cross Infection - drug therapy</topic><topic>Cross Infection - epidemiology</topic><topic>Cross Infection - transmission</topic><topic>Disease Outbreaks</topic><topic>Enterococci</topic><topic>Enterococcus faecium - isolation & purification</topic><topic>Epidemiology</topic><topic>Feces - microbiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gram-Positive Bacterial Infections - drug therapy</topic><topic>Gram-Positive Bacterial Infections - epidemiology</topic><topic>Gram-Positive Bacterial Infections - transmission</topic><topic>Hospital Bed Capacity, 500 and over</topic><topic>Hospitals, University</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Length of Stay</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Norway - epidemiology</topic><topic>PENICILINA</topic><topic>PENICILLINE</topic><topic>PENICILLINS</topic><topic>Prevalence</topic><topic>Regression Analysis</topic><topic>RESISTANCE AUX PRODUITS CHIMIQUES</topic><topic>RESISTANCE TO CHEMICALS</topic><topic>RESISTENCIA A PRODUCTOS QUIMICOS</topic><topic>Risk Factors</topic><topic>STREPTOCOCCUS FAECIUM</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mohn, S.C. (Haukeland Sykehus (Bergen))</creatorcontrib><creatorcontrib>Harthug, S</creatorcontrib><creatorcontrib>Langeland, N</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>APMIS : acta pathologica, microbiologica et immunologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mohn, S.C. (Haukeland Sykehus (Bergen))</au><au>Harthug, S</au><au>Langeland, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outbreak of ampicillin-resistant Enterococcus faecium: risk factors for faecal colonisation</atitle><jtitle>APMIS : acta pathologica, microbiologica et immunologica Scandinavica</jtitle><addtitle>APMIS</addtitle><date>2000-04-01</date><risdate>2000</risdate><volume>108</volume><issue>4</issue><spage>296</spage><epage>302</epage><pages>296-302</pages><issn>0903-4641</issn><eissn>1600-0463</eissn><abstract>Since January 1995 there has been a nosocomial outbreak at Haukeland University Hospital involving more than 330 patients with clinical infections caused by ampicillin‐resistant Enterococcus faecium (ARE) (minimum inhibitory concentration ≥32 mg/l). Rectal carriage of ARE was initially observed on two medical wards only. Here the ARE colonisation rate has remained high. To assess risk factors for ARE colonisation we performed a case‐control study including 37 rectal carriers of ARE and 83 non‐carriers on these wards. Significant differences were found between cases and controls with respect to the mean number of days on antimicrobial treatment (13.3 for carriers, 5.5 for non‐carriers, p<0.001), mean number of different antibiotics prescribed (2.8 for carriers, 2.1 for non‐carriers, p=0.008) and mean number of days in hospital (18.4 vs 10.2, p=0.001). Unadjusted statistical analysis showed that several antibiotics were risk factors for ARE carriage. Logistic regression analysis showed that fluoroquinolone prescription (OR=3.5, p=0.01) and more than 10 days of antibiotic use (OR=3.3, p=0.01) were significant risk factors. An additional follow‐up screening of previous carriers revealed no colonisation 8 to 36 (median 9) months after discharge from hospital (n=17). Prolonged antimicrobial therapy and broad‐spectrum antibiotics seem to facilitate nosocomial ARE colonisation.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>10843419</pmid><doi>10.1034/j.1600-0463.2000.d01-60.x</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0903-4641 |
| ispartof | APMIS : acta pathologica, microbiologica et immunologica Scandinavica, 2000-04, Vol.108 (4), p.296-302 |
| issn | 0903-4641 1600-0463 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Ampicillin Resistance Analysis of Variance Anti-Bacterial Agents - therapeutic use APTITUD COLONIZADORA APTITUDE A COLONISER Bacterial diseases Bacterial diseases of the digestive system and abdomen Bacteriology Biological and medical sciences Carrier State - epidemiology Case-Control Studies colonisation COLONIZING ABILITY Cross Infection - drug therapy Cross Infection - epidemiology Cross Infection - transmission Disease Outbreaks Enterococci Enterococcus faecium - isolation & purification Epidemiology Feces - microbiology Fundamental and applied biological sciences. Psychology Gram-Positive Bacterial Infections - drug therapy Gram-Positive Bacterial Infections - epidemiology Gram-Positive Bacterial Infections - transmission Hospital Bed Capacity, 500 and over Hospitals, University Human bacterial diseases Humans Infectious diseases Length of Stay Medical sciences Microbiology Norway - epidemiology PENICILINA PENICILLINE PENICILLINS Prevalence Regression Analysis RESISTANCE AUX PRODUITS CHIMIQUES RESISTANCE TO CHEMICALS RESISTENCIA A PRODUCTOS QUIMICOS Risk Factors STREPTOCOCCUS FAECIUM |
| title | Outbreak of ampicillin-resistant Enterococcus faecium: risk factors for faecal colonisation |
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