Caveolae: from basic trafficking mechanisms to targeting transcytosis for tissue-specific drug and gene delivery in vivo
Continuous endothelium and epithelium create formidable barriers to endogenous molecules as well as targeted drug and gene therapies in vivo. Caveolae represent a possible vesicular trafficking pathway through cell barriers. Here we discuss recent discoveries regarding the basic function of caveolae...
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| Veröffentlicht in: | Advanced drug delivery reviews 2001-07, Vol.49 (3), p.265-280 |
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| container_title | Advanced drug delivery reviews |
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| creator | Schnitzer, Jan E |
| description | Continuous endothelium and epithelium create formidable barriers to endogenous molecules as well as targeted drug and gene therapies in vivo. Caveolae represent a possible vesicular trafficking pathway through cell barriers. Here we discuss recent discoveries regarding the basic function of caveolae in transport including transcellular trafficking, intracellular trafficking to distinct endosomes, and molecular mechanisms mediating their budding, docking and fusion (dynamin and SNARE machinery). New technologies to purify and map caveolae as well as generate new probes selectively targeting caveolae in vivo provide valuable tools not only for investigating caveolar endocytosis/transcytosis but also elucidating new potential applications for site-directed treatment of many diseases. Vascular targeting of the caveolar trafficking pathway may be a useful strategy for achieving tissue-specific pharmacodelivery that also overcomes key, normally restrictive cell barriers which greatly reduce the efficacy of many therapies in vivo. |
| doi_str_mv | 10.1016/S0169-409X(01)00141-7 |
| format | Article |
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Caveolae represent a possible vesicular trafficking pathway through cell barriers. Here we discuss recent discoveries regarding the basic function of caveolae in transport including transcellular trafficking, intracellular trafficking to distinct endosomes, and molecular mechanisms mediating their budding, docking and fusion (dynamin and SNARE machinery). New technologies to purify and map caveolae as well as generate new probes selectively targeting caveolae in vivo provide valuable tools not only for investigating caveolar endocytosis/transcytosis but also elucidating new potential applications for site-directed treatment of many diseases. Vascular targeting of the caveolar trafficking pathway may be a useful strategy for achieving tissue-specific pharmacodelivery that also overcomes key, normally restrictive cell barriers which greatly reduce the efficacy of many therapies in vivo.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Caveolae</subject><subject>Caveolae - metabolism</subject><subject>Cell physiology</subject><subject>Drug delivery</subject><subject>Drug Delivery Systems</subject><subject>Dynamin</subject><subject>Endocytosis</subject><subject>Endosome</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene therapy</subject><subject>General pharmacology</subject><subject>Genetic Therapy - methods</subject><subject>Genetic Vectors</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Membrane and intracellular transports</subject><subject>Molecular and cellular biology</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. 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| fulltext | fulltext |
| identifier | ISSN: 0169-409X |
| ispartof | Advanced drug delivery reviews, 2001-07, Vol.49 (3), p.265-280 |
| issn | 0169-409X 1872-8294 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biological and medical sciences Caveolae Caveolae - metabolism Cell physiology Drug delivery Drug Delivery Systems Dynamin Endocytosis Endosome Fundamental and applied biological sciences. Psychology Gene therapy General pharmacology Genetic Therapy - methods Genetic Vectors Humans Medical sciences Membrane and intracellular transports Molecular and cellular biology Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Trafficking Transcytosis VAMP |
| title | Caveolae: from basic trafficking mechanisms to targeting transcytosis for tissue-specific drug and gene delivery in vivo |
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