New insights into the transmembrane protein tyrosine phosphatase CD45
CD45 is expressed on all nucleated haematopoietic cells and was originally identified as the first and prototypic transmembrane protein tyrosine phosphatase. In CD45 mutant cell lines, CD45-deficient mice and CD45-deficient human SCID patients, CD45 is required for signal transduction through antige...
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| Veröffentlicht in: | The international journal of biochemistry & cell biology 2001-11, Vol.33 (11), p.1041-1046 |
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| container_end_page | 1046 |
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| container_issue | 11 |
| container_start_page | 1041 |
| container_title | The international journal of biochemistry & cell biology |
| container_volume | 33 |
| creator | Sasaki, Takehiko Sasaki-Irie, Junko Penninger, Josef M. |
| description | CD45 is expressed on all nucleated haematopoietic cells and was originally identified as the first and prototypic transmembrane protein tyrosine phosphatase. In CD45 mutant cell lines, CD45-deficient mice and CD45-deficient human SCID patients, CD45 is required for signal transduction through antigen receptors. CD45 can operate as a positive as well as a negative regulator of Src-family kinases. Moreover, CD45 was identified as the elusive JAK tyrosine phosphatase that negatively regulates cytokine receptor activation involved in the differentiation, proliferation and antiviral immunity of haematopoietic cells. Modulation of CD45 splice variants provides a unique opportunity to design drugs that turn off or turn on antigen and cytokine receptor signaling in cancer, transplantation or autoimmunity |
| doi_str_mv | 10.1016/S1357-2725(01)00075-9 |
| format | Article |
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| identifier | ISSN: 1357-2725 |
| ispartof | The international journal of biochemistry & cell biology, 2001-11, Vol.33 (11), p.1041-1046 |
| issn | 1357-2725 1878-5875 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Cytokine Enzyme Activation Humans Leukocyte Common Antigens - chemistry Leukocyte Common Antigens - genetics Leukocyte Common Antigens - metabolism Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism Protein tyrosine phosphatase Protein-Tyrosine Kinases - metabolism Signal Transduction T cell activation |
| title | New insights into the transmembrane protein tyrosine phosphatase CD45 |
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