Clinical Evaluation of Commercial Serological Test for Bartonella Infection
We evaluated the usefulness of a serological diagnostic kit (Bartonella IFA IgG, IgM; MRL Diagnostics) for Bartonella henselae infection. Of the 110 healthy individuals, 107 (97.3%) were with titers being less than 1: 64 for IgG antibody to B. henselae, 2 were with titers being 1: 64 and 1 with 1: 1...
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| Veröffentlicht in: | Kansenshogaku Zasshi 2000/04/20, Vol.74(4), pp.387-391 |
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| container_title | Kansenshogaku Zasshi |
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| creator | TSUNEOKA, Hidehiro FUJII, Reiko FUJISAWA, Keiko IINO, Hidechika ISIDA, Chizuru MURAKAMI, Kyoko TSUKAHARA, Masato |
| description | We evaluated the usefulness of a serological diagnostic kit (Bartonella IFA IgG, IgM; MRL Diagnostics) for Bartonella henselae infection. Of the 110 healthy individuals, 107 (97.3%) were with titers being less than 1: 64 for IgG antibody to B. henselae, 2 were with titers being 1: 64 and 1 with 1: 128. IgM antibody to B. henselae was negative in all individuals. Serological diagnosis of cat scratch disease (CSD) using indirect fluorescence antibody (IFA) methods (in-house and diagnostic kit) was made in either elevated titers of IgM (≥1: 20) or IgG (≥1: 256) antibodies, or a four-fold rise in IgG titer between acute and convalescent sera. Of the 18 individuals with serological diagnosis of CSD by in-house IFA method in 26 CSD clinical diagnosed patients, 15 (83%) were compatible with the results of the diagnostic kit, whereas 3 (17%) were not compatible. Of the 8 without serological diagnosis, 1 (13%) was serologically diagnosed as CSD, and the others were negative. Overall, the serological diagnosis was made in 16 of 26 (62%). The specificity and sensitivity of this kit were 100% and 62%, respectively. The cross-reaction between B. henselae and Bartonella quintana was observed in sera from comtrols and patients. Our results show that the diagnostic kit as well as in-house method is an useful tool for the serological diagnosis of cat scratch disease. |
| doi_str_mv | 10.11150/kansenshogakuzasshi1970.74.387 |
| format | Article |
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Of the 110 healthy individuals, 107 (97.3%) were with titers being less than 1: 64 for IgG antibody to B. henselae, 2 were with titers being 1: 64 and 1 with 1: 128. IgM antibody to B. henselae was negative in all individuals. Serological diagnosis of cat scratch disease (CSD) using indirect fluorescence antibody (IFA) methods (in-house and diagnostic kit) was made in either elevated titers of IgM (≥1: 20) or IgG (≥1: 256) antibodies, or a four-fold rise in IgG titer between acute and convalescent sera. Of the 18 individuals with serological diagnosis of CSD by in-house IFA method in 26 CSD clinical diagnosed patients, 15 (83%) were compatible with the results of the diagnostic kit, whereas 3 (17%) were not compatible. Of the 8 without serological diagnosis, 1 (13%) was serologically diagnosed as CSD, and the others were negative. Overall, the serological diagnosis was made in 16 of 26 (62%). The specificity and sensitivity of this kit were 100% and 62%, respectively. The cross-reaction between B. henselae and Bartonella quintana was observed in sera from comtrols and patients. Our results show that the diagnostic kit as well as in-house method is an useful tool for the serological diagnosis of cat scratch disease.</description><identifier>ISSN: 0387-5911</identifier><identifier>EISSN: 1884-569X</identifier><identifier>DOI: 10.11150/kansenshogakuzasshi1970.74.387</identifier><identifier>PMID: 10835846</identifier><language>eng ; jpn</language><publisher>Japan: The Japanese Association for Infectious Diseases</publisher><subject>Adolescent ; Adult ; Aged ; Bartonella henselae ; cat scratch disease ; Cat-Scratch Disease - immunology ; Child ; Child, Preschool ; Evaluation Studies as Topic ; Female ; Humans ; IgG antibody ; IgM antibody ; indirect fluorescence antibody ; Infant ; Male ; Middle Aged ; Reagent Kits, Diagnostic - standards ; Serologic Tests - instrumentation</subject><ispartof>Kansenshogaku Zasshi, 2000/04/20, Vol.74(4), pp.387-391</ispartof><rights>The Japansese Association for Infectious Diseases</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3737-7172d903a950512726214c2b4ee54e6e0e799bd436e837a44a812512bb9b5ba13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10835846$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TSUNEOKA, Hidehiro</creatorcontrib><creatorcontrib>FUJII, Reiko</creatorcontrib><creatorcontrib>FUJISAWA, Keiko</creatorcontrib><creatorcontrib>IINO, Hidechika</creatorcontrib><creatorcontrib>ISIDA, Chizuru</creatorcontrib><creatorcontrib>MURAKAMI, Kyoko</creatorcontrib><creatorcontrib>TSUKAHARA, Masato</creatorcontrib><title>Clinical Evaluation of Commercial Serological Test for Bartonella Infection</title><title>Kansenshogaku Zasshi</title><addtitle>J. J. A. Inf. D</addtitle><description>We evaluated the usefulness of a serological diagnostic kit (Bartonella IFA IgG, IgM; MRL Diagnostics) for Bartonella henselae infection. Of the 110 healthy individuals, 107 (97.3%) were with titers being less than 1: 64 for IgG antibody to B. henselae, 2 were with titers being 1: 64 and 1 with 1: 128. IgM antibody to B. henselae was negative in all individuals. Serological diagnosis of cat scratch disease (CSD) using indirect fluorescence antibody (IFA) methods (in-house and diagnostic kit) was made in either elevated titers of IgM (≥1: 20) or IgG (≥1: 256) antibodies, or a four-fold rise in IgG titer between acute and convalescent sera. Of the 18 individuals with serological diagnosis of CSD by in-house IFA method in 26 CSD clinical diagnosed patients, 15 (83%) were compatible with the results of the diagnostic kit, whereas 3 (17%) were not compatible. Of the 8 without serological diagnosis, 1 (13%) was serologically diagnosed as CSD, and the others were negative. Overall, the serological diagnosis was made in 16 of 26 (62%). The specificity and sensitivity of this kit were 100% and 62%, respectively. The cross-reaction between B. henselae and Bartonella quintana was observed in sera from comtrols and patients. Our results show that the diagnostic kit as well as in-house method is an useful tool for the serological diagnosis of cat scratch disease.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Bartonella henselae</subject><subject>cat scratch disease</subject><subject>Cat-Scratch Disease - immunology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Evaluation Studies as Topic</subject><subject>Female</subject><subject>Humans</subject><subject>IgG antibody</subject><subject>IgM antibody</subject><subject>indirect fluorescence antibody</subject><subject>Infant</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Reagent Kits, Diagnostic - standards</subject><subject>Serologic Tests - instrumentation</subject><issn>0387-5911</issn><issn>1884-569X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMouqz-BelJT12TJmmak-iyfqDgYVfwFtLsdDfaNpq0gv56s1sRL3qZwOSZd4YHoVOCJ4QQjs9edBugDWu30i_9pw5hbYkUeCLYhBZiB41IUbCU5_JpF41wbKVcEnKAjkKwJcZYMpzxbB8dEFxQXrB8hO6mtW2t0XUye9d1rzvr2sRVydQ1DXhj48ccvKvdagstIHRJ5XxyqX3nWqhrndy2FZjN3CHaq3Qd4Oj7HaPHq9liepPeP1zfTi_uU0MFFakgIltKTLXkmJNMZHlGmMlKBsAZ5IBBSFkuGc2hoEIzpguSRbAsZclLTegYnQy5r9699fEi1dhgNre04PqgRJQlBMURPB9A410IHir16m2j_YciWG2Vqj-UKsFU9BcTjr9X9WUDy1_zg8AIzAfgOXR6BT9A1GNNDf_ls6HENT-0WWuvoKVfh1SX1g</recordid><startdate>200004</startdate><enddate>200004</enddate><creator>TSUNEOKA, Hidehiro</creator><creator>FUJII, Reiko</creator><creator>FUJISAWA, Keiko</creator><creator>IINO, Hidechika</creator><creator>ISIDA, Chizuru</creator><creator>MURAKAMI, Kyoko</creator><creator>TSUKAHARA, Masato</creator><general>The Japanese Association for Infectious Diseases</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200004</creationdate><title>Clinical Evaluation of Commercial Serological Test for Bartonella Infection</title><author>TSUNEOKA, Hidehiro ; FUJII, Reiko ; FUJISAWA, Keiko ; IINO, Hidechika ; ISIDA, Chizuru ; MURAKAMI, Kyoko ; TSUKAHARA, Masato</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3737-7172d903a950512726214c2b4ee54e6e0e799bd436e837a44a812512bb9b5ba13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; jpn</language><creationdate>2000</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Bartonella henselae</topic><topic>cat scratch disease</topic><topic>Cat-Scratch Disease - immunology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Evaluation Studies as Topic</topic><topic>Female</topic><topic>Humans</topic><topic>IgG antibody</topic><topic>IgM antibody</topic><topic>indirect fluorescence antibody</topic><topic>Infant</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Reagent Kits, Diagnostic - standards</topic><topic>Serologic Tests - instrumentation</topic><toplevel>online_resources</toplevel><creatorcontrib>TSUNEOKA, Hidehiro</creatorcontrib><creatorcontrib>FUJII, Reiko</creatorcontrib><creatorcontrib>FUJISAWA, Keiko</creatorcontrib><creatorcontrib>IINO, Hidechika</creatorcontrib><creatorcontrib>ISIDA, Chizuru</creatorcontrib><creatorcontrib>MURAKAMI, Kyoko</creatorcontrib><creatorcontrib>TSUKAHARA, Masato</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Kansenshogaku Zasshi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TSUNEOKA, Hidehiro</au><au>FUJII, Reiko</au><au>FUJISAWA, Keiko</au><au>IINO, Hidechika</au><au>ISIDA, Chizuru</au><au>MURAKAMI, Kyoko</au><au>TSUKAHARA, Masato</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Evaluation of Commercial Serological Test for Bartonella Infection</atitle><jtitle>Kansenshogaku Zasshi</jtitle><addtitle>J. J. A. Inf. D</addtitle><date>2000-04</date><risdate>2000</risdate><volume>74</volume><issue>4</issue><spage>387</spage><epage>391</epage><pages>387-391</pages><issn>0387-5911</issn><eissn>1884-569X</eissn><abstract>We evaluated the usefulness of a serological diagnostic kit (Bartonella IFA IgG, IgM; MRL Diagnostics) for Bartonella henselae infection. Of the 110 healthy individuals, 107 (97.3%) were with titers being less than 1: 64 for IgG antibody to B. henselae, 2 were with titers being 1: 64 and 1 with 1: 128. IgM antibody to B. henselae was negative in all individuals. Serological diagnosis of cat scratch disease (CSD) using indirect fluorescence antibody (IFA) methods (in-house and diagnostic kit) was made in either elevated titers of IgM (≥1: 20) or IgG (≥1: 256) antibodies, or a four-fold rise in IgG titer between acute and convalescent sera. Of the 18 individuals with serological diagnosis of CSD by in-house IFA method in 26 CSD clinical diagnosed patients, 15 (83%) were compatible with the results of the diagnostic kit, whereas 3 (17%) were not compatible. Of the 8 without serological diagnosis, 1 (13%) was serologically diagnosed as CSD, and the others were negative. Overall, the serological diagnosis was made in 16 of 26 (62%). The specificity and sensitivity of this kit were 100% and 62%, respectively. The cross-reaction between B. henselae and Bartonella quintana was observed in sera from comtrols and patients. Our results show that the diagnostic kit as well as in-house method is an useful tool for the serological diagnosis of cat scratch disease.</abstract><cop>Japan</cop><pub>The Japanese Association for Infectious Diseases</pub><pmid>10835846</pmid><doi>10.11150/kansenshogakuzasshi1970.74.387</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0387-5911 |
| ispartof | Kansenshogaku Zasshi, 2000/04/20, Vol.74(4), pp.387-391 |
| issn | 0387-5911 1884-569X |
| language | eng ; jpn |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Open Access Titles of Japan; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Bartonella henselae cat scratch disease Cat-Scratch Disease - immunology Child Child, Preschool Evaluation Studies as Topic Female Humans IgG antibody IgM antibody indirect fluorescence antibody Infant Male Middle Aged Reagent Kits, Diagnostic - standards Serologic Tests - instrumentation |
| title | Clinical Evaluation of Commercial Serological Test for Bartonella Infection |
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