Phenylephrine Precontraction Increases the Sensitivity of Rabbit Femoral Artery to Serotonin by Enabling 5-HT1-Like Receptors

We used selective receptor antagonists to identify the receptors mediating the isometric contractile response to serotonin in control and phenylephrine (PHE)-precontracted rabbit femoral artery rings. Serotonin, in the absence of PHE, elicited monophasic concentration-response curves (CRCs) early, b...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 2000-06, Vol.35 (6), p.863-870
Hauptverfasser:	Chen, Justin, Yildiz, Oguzhan, Purdy, Ralph E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Dose-Response Relationship, Drug Femoral Artery - drug effects Femoral Artery - physiology Fundamental and applied biological sciences. Psychology Heart Hemodynamics. Rheology In Vitro Techniques Oxadiazoles - pharmacology Phenylephrine - pharmacology Piperazines - pharmacology Prazosin - pharmacology Rabbits Receptors, Serotonin - drug effects Receptors, Serotonin - physiology Ritanserin - pharmacology Serotonin - pharmacology Serotonin Antagonists - pharmacology Serotonin Receptor Agonists - pharmacology Specific Pathogen-Free Organisms Sumatriptan - pharmacology Vasoconstriction - drug effects Vertebrates: cardiovascular system
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