Simulation of clinical trials
Computer simulation of clinical trials has evolved over the past two decades from a simple instructive game to "full" simulation models yielding pharmacologically sound, realistic trial outcomes. The need to make drug development more efficient and informative and the awareness that many i...
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| Veröffentlicht in: | Annual review of pharmacology and toxicology 2000-01, Vol.40 (1), p.209-234 |
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| container_title | Annual review of pharmacology and toxicology |
| container_volume | 40 |
| creator | Holford, N H Kimko, H C Monteleone, J P Peck, C C |
| description | Computer simulation of clinical trials has evolved over the past two decades from a simple instructive game to "full" simulation models yielding pharmacologically sound, realistic trial outcomes. The need to make drug development more efficient and informative and the awareness that many industries make extensive use of simulation in product development have advanced considerably the use of simulation of clinical trials in pharmaceutical product development over the past decade. The structural and stochastic components of trial simulation models are explained as a prelude to a listing of representative simulation projects, reflecting investigative applications of statistical methods, trial design comparisons, and full simulation of new drugs being developed. Lessons learned from these projects are reviewed in the context of their current impact and potential for influencing the future of drug development. |
| doi_str_mv | 10.1146/annurev.pharmtox.40.1.209 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0362-1642 |
| ispartof | Annual review of pharmacology and toxicology, 2000-01, Vol.40 (1), p.209-234 |
| issn | 0362-1642 1545-4304 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71156802 |
| source | Annual Reviews Complete A-Z List; MEDLINE |
| subjects | Clinical Trials as Topic Computer Simulation Humans Research Design Software |
| title | Simulation of clinical trials |
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