Loss of purinergic P2X(3) and P2X(5) receptor innervation in human detrusor from adults with urge incontinence

Activation of purinergic P2X receptors associated with the parasympathetic nerves that supply the human bladder smooth muscle (detrusor) is implicated in control of detrusor contractility. The relative abundance of all seven subtypes colocalized with synaptic vesicles on parasympathetic nerves was e...

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Veröffentlicht in:	The Journal of neuroscience 2001-09, Vol.21 (18), p.RC166-RC166
Hauptverfasser:	Moore, K H, Ray, F R, Barden, J A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Aging - metabolism Biopsy Child, Preschool Humans Immunohistochemistry Infant Middle Aged Muscle, Smooth - innervation Muscle, Smooth - metabolism Muscle, Smooth - pathology Parasympathetic Nervous System - metabolism Parasympathetic Nervous System - pathology Receptors, Purinergic P2 - deficiency Receptors, Purinergic P2 - metabolism Receptors, Purinergic P2X3 Receptors, Purinergic P2X5 Synaptic Vesicles - metabolism Synaptic Vesicles - pathology Urinary Bladder - innervation Urinary Bladder - pathology Urinary Bladder - physiopathology Urinary Bladder, Neurogenic - complications Urinary Bladder, Neurogenic - physiopathology Urinary Incontinence - etiology Urinary Incontinence - pathology Urinary Incontinence - physiopathology
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