Glucocorticoid inhibition of neuropathic limb edema and cutaneous neurogenic extravasation

Sciatic nerve section in rats evokes chronic limb edema, pain behavior, and hindpaw hyperalgesia, a syndrome resembling the complex regional pain syndrome type II (CRPS II or causalgia) in man. Glucocorticoids such as methylprednisolone (MP) have been used as analgesic and anti-edematous agents in p...

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Veröffentlicht in:	Brain research 2001-09, Vol.913 (2), p.140-148
Hauptverfasser:	Kingery, Wade S, Guo, Tian-Zhi, Agashe, Geeta S, Davies, M.Frances, Clark, J.David, Maze, Mervyn
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Capillary Permeability - drug effects Capillary Permeability - physiology Causalgia - drug therapy Causalgia - pathology Causalgia - physiopathology Complex regional pain syndrome Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction Disease Models, Animal Dose-Response Relationship, Drug Edema Edema - drug therapy Edema - etiology Edema - physiopathology Foot - innervation Foot - pathology Foot - physiopathology Ganglia, Spinal - cytology Ganglia, Spinal - drug effects Ganglia, Spinal - metabolism Glucocorticoid Glucocorticoids - pharmacology Hindlimb - innervation Hindlimb - pathology Hindlimb - physiopathology Lymphatic System - cytology Lymphatic System - drug effects Lymphatic System - innervation Male Medical sciences Methylprednisolone Methylprednisolone - pharmacology Nerve Fibers - drug effects Nerve Fibers - metabolism Nerve Fibers - ultrastructure Nerve injury Nervous system (semeiology, syndromes) Neurogenic extravasation Neurology Neurons, Afferent - cytology Neurons, Afferent - drug effects Neurons, Afferent - metabolism Peripheral Nervous System Diseases - complications Peripheral Nervous System Diseases - drug therapy Peripheral Nervous System Diseases - physiopathology Rats Rats, Sprague-Dawley Regional Blood Flow - drug effects Regional Blood Flow - physiology Sciatic Nerve - injuries Sciatic Nerve - physiopathology Sciatic Nerve - surgery Time Factors
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