Myocytes Isolated from Rejecting Transplanted Rat Hearts Exhibit a Nitric Oxide-mediated Reduction in the Calcium Current

During periods of acute rejection, transplanted hearts have increased nitric oxide (NO) production and depressed contractile function. Myocytes isolated from rejecting hearts exhibit parallel increases in NO production and reduced shortening, indicating that the contractile dysfunction of the transp...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2001-09, Vol.33 (9), p.1691-1699
Hauptverfasser:	Ziolo, Mark T., Harshbarger, Carol H., Roycroft, Karen E., Smith, Jacquelyn M., Romano, Fred D., Sondgeroth, Korie L., Wahler, Gordon M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - pharmacology Animals Arginine - pharmacology Calcium - metabolism Calcium channels Carbazoles Cardiac transplantation Cyclic GMP Cyclic GMP-Dependent Protein Kinases - antagonists & inhibitors Electrophysiology Enzyme Inhibitors - pharmacology Graft rejection Graft Rejection - physiopathology Guanidines - pharmacology Heart - drug effects Heart - physiology Heart Transplantation Humans In Vitro Techniques Indoles Inducible nitric oxide synthase Muscle Contraction - physiology Myocardium - cytology Myocardium - metabolism Nitric Oxide - metabolism Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - genetics Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type II Rats Transplantation, Autologous Transplantation, Homologous
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