Vascular Endothelial Growth Factor and Angiopoietin in Liver Regeneration
Liver architecture remodeling following partial hepatectomy (PHx) involves the formation of a complex network of liver sinusoids through which the blood flows. The present study examines the involvement of vascular endothelial growth factor (VEGF) and angiopoietin-1 (ang-1) during liver regeneration...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2001-09, Vol.287 (1), p.209-215 |
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| creator | Kraizer, Yehudit Mawasi, Nidal Seagal, Jane Paizi, Melia Assy, Nimer Spira, Gadi |
| description | Liver architecture remodeling following partial hepatectomy (PHx) involves the formation of a complex network of liver sinusoids through which the blood flows. The present study examines the involvement of vascular endothelial growth factor (VEGF) and angiopoietin-1 (ang-1) during liver regeneration. Following PHx, VEGF and ang-1 mRNA levels increase, followed by gradual return to baseline levels. RT-PCR analysis of VEGF mRNA reveals three isoforms, VEGF120, VEGF164 and VEGF188. Of the three, VEGF188 is the predominant isoform, VEGF120 being the less abundant. Although VEGF mRNA fluctuates following PHx, the relative expression of each isoform remains the same throughout the recovery process. The level of neuropilin-1, an accessory receptor of VEGF to main receptor corresponds with that of VEGF and ang-1. We have previously demonstrated the capacity of exogenous VEGF165 to stimulate liver cell proliferation following PHx. We now report similar effect using VEGF121, further demonstrating the benefit of manipulating growth factors where such an intervention is required. |
| doi_str_mv | 10.1006/bbrc.2001.5548 |
| format | Article |
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The present study examines the involvement of vascular endothelial growth factor (VEGF) and angiopoietin-1 (ang-1) during liver regeneration. Following PHx, VEGF and ang-1 mRNA levels increase, followed by gradual return to baseline levels. RT-PCR analysis of VEGF mRNA reveals three isoforms, VEGF120, VEGF164 and VEGF188. Of the three, VEGF188 is the predominant isoform, VEGF120 being the less abundant. Although VEGF mRNA fluctuates following PHx, the relative expression of each isoform remains the same throughout the recovery process. The level of neuropilin-1, an accessory receptor of VEGF to main receptor corresponds with that of VEGF and ang-1. We have previously demonstrated the capacity of exogenous VEGF165 to stimulate liver cell proliferation following PHx. 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The present study examines the involvement of vascular endothelial growth factor (VEGF) and angiopoietin-1 (ang-1) during liver regeneration. Following PHx, VEGF and ang-1 mRNA levels increase, followed by gradual return to baseline levels. RT-PCR analysis of VEGF mRNA reveals three isoforms, VEGF120, VEGF164 and VEGF188. Of the three, VEGF188 is the predominant isoform, VEGF120 being the less abundant. Although VEGF mRNA fluctuates following PHx, the relative expression of each isoform remains the same throughout the recovery process. The level of neuropilin-1, an accessory receptor of VEGF to main receptor corresponds with that of VEGF and ang-1. We have previously demonstrated the capacity of exogenous VEGF165 to stimulate liver cell proliferation following PHx. We now report similar effect using VEGF121, further demonstrating the benefit of manipulating growth factors where such an intervention is required.</description><subject>angiopoietin</subject><subject>Angiopoietin-1</subject><subject>Animals</subject><subject>Cell Division - drug effects</subject><subject>Endothelial Growth Factors - blood</subject><subject>Endothelial Growth Factors - genetics</subject><subject>Endothelial Growth Factors - metabolism</subject><subject>Endothelial Growth Factors - pharmacology</subject><subject>Gene Expression</subject><subject>Hepatectomy</subject><subject>liver regeneration</subject><subject>Liver Regeneration - drug effects</subject><subject>Liver Regeneration - physiology</subject><subject>Lymphokines - blood</subject><subject>Lymphokines - genetics</subject><subject>Lymphokines - metabolism</subject><subject>Lymphokines - pharmacology</subject><subject>Male</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Membrane Glycoproteins - metabolism</subject><subject>Models, Animal</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>neuropilin</subject><subject>Neuropilin-1</subject><subject>partial hepatectomy</subject><subject>Proliferating Cell Nuclear Antigen - analysis</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>RNA, Messenger - metabolism</subject><subject>Vascular Endothelial Growth Factor A</subject><subject>Vascular Endothelial Growth Factors</subject><subject>VEGF</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEFLwzAYhoMobk6vHqUnb61J2mbtcQw3BwNBVLyFNPm6RbpkJunEf2_KBp6ED77L877wPgjdEpwRjNlD0ziZUYxJVpZFdYbGBNc4pQQX52iMI5HSmnyM0JX3n5EiBasv0YiQsqjplI3R6l142XfCJY9G2bCFTosuWTr7HbbJQshgXSKMSmZmo-3eagjaJPHW-gAueYENGHAiaGuu0UUrOg83pz9Bb4vH1_lTun5eruazdSoLzEJaStY2UKkWF6rMJZaSUKpaQmtV1S1tpqwmilWylG0LTSMZy0socNHkuKwUiHyC7o-9e2e_evCB77SX0HXCgO09n8ZxUQiOYHYEpbPeO2j53umdcD-cYD7I44M8Psjjg7wYuDs1980O1B9-shWB6ghA3HfQ4LiXGowEpR3IwJXV_3X_AlhDfrQ</recordid><startdate>20010914</startdate><enddate>20010914</enddate><creator>Kraizer, Yehudit</creator><creator>Mawasi, Nidal</creator><creator>Seagal, Jane</creator><creator>Paizi, Melia</creator><creator>Assy, Nimer</creator><creator>Spira, Gadi</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010914</creationdate><title>Vascular Endothelial Growth Factor and Angiopoietin in Liver Regeneration</title><author>Kraizer, Yehudit ; Mawasi, Nidal ; Seagal, Jane ; Paizi, Melia ; Assy, Nimer ; Spira, Gadi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-5c6fbe8df04d53c0cc122df129d89f2b7691d68c5cffebbc6635e404b3058dea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>angiopoietin</topic><topic>Angiopoietin-1</topic><topic>Animals</topic><topic>Cell Division - drug effects</topic><topic>Endothelial Growth Factors - blood</topic><topic>Endothelial Growth Factors - genetics</topic><topic>Endothelial Growth Factors - metabolism</topic><topic>Endothelial Growth Factors - pharmacology</topic><topic>Gene Expression</topic><topic>Hepatectomy</topic><topic>liver regeneration</topic><topic>Liver Regeneration - drug effects</topic><topic>Liver Regeneration - physiology</topic><topic>Lymphokines - blood</topic><topic>Lymphokines - genetics</topic><topic>Lymphokines - metabolism</topic><topic>Lymphokines - pharmacology</topic><topic>Male</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Membrane Glycoproteins - metabolism</topic><topic>Models, Animal</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>neuropilin</topic><topic>Neuropilin-1</topic><topic>partial hepatectomy</topic><topic>Proliferating Cell Nuclear Antigen - analysis</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>RNA, Messenger - metabolism</topic><topic>Vascular Endothelial Growth Factor A</topic><topic>Vascular Endothelial Growth Factors</topic><topic>VEGF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kraizer, Yehudit</creatorcontrib><creatorcontrib>Mawasi, Nidal</creatorcontrib><creatorcontrib>Seagal, Jane</creatorcontrib><creatorcontrib>Paizi, Melia</creatorcontrib><creatorcontrib>Assy, Nimer</creatorcontrib><creatorcontrib>Spira, Gadi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kraizer, Yehudit</au><au>Mawasi, Nidal</au><au>Seagal, Jane</au><au>Paizi, Melia</au><au>Assy, Nimer</au><au>Spira, Gadi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vascular Endothelial Growth Factor and Angiopoietin in Liver Regeneration</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2001-09-14</date><risdate>2001</risdate><volume>287</volume><issue>1</issue><spage>209</spage><epage>215</epage><pages>209-215</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Liver architecture remodeling following partial hepatectomy (PHx) involves the formation of a complex network of liver sinusoids through which the blood flows. The present study examines the involvement of vascular endothelial growth factor (VEGF) and angiopoietin-1 (ang-1) during liver regeneration. Following PHx, VEGF and ang-1 mRNA levels increase, followed by gradual return to baseline levels. RT-PCR analysis of VEGF mRNA reveals three isoforms, VEGF120, VEGF164 and VEGF188. Of the three, VEGF188 is the predominant isoform, VEGF120 being the less abundant. Although VEGF mRNA fluctuates following PHx, the relative expression of each isoform remains the same throughout the recovery process. The level of neuropilin-1, an accessory receptor of VEGF to main receptor corresponds with that of VEGF and ang-1. We have previously demonstrated the capacity of exogenous VEGF165 to stimulate liver cell proliferation following PHx. 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| subjects | angiopoietin Angiopoietin-1 Animals Cell Division - drug effects Endothelial Growth Factors - blood Endothelial Growth Factors - genetics Endothelial Growth Factors - metabolism Endothelial Growth Factors - pharmacology Gene Expression Hepatectomy liver regeneration Liver Regeneration - drug effects Liver Regeneration - physiology Lymphokines - blood Lymphokines - genetics Lymphokines - metabolism Lymphokines - pharmacology Male Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Models, Animal Nerve Tissue Proteins - metabolism neuropilin Neuropilin-1 partial hepatectomy Proliferating Cell Nuclear Antigen - analysis Rats Rats, Sprague-Dawley RNA, Messenger - metabolism Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors VEGF |
| title | Vascular Endothelial Growth Factor and Angiopoietin in Liver Regeneration |
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