Computer-aided design of beta-sheet peptides

The design of beta-sheet proteins is still a challenge in the field of de novo protein design. Here, we have tested the validity of automatic design methods to create and/or improve beta-sheet peptides and proteins. We chose Betanova, a three-stranded beta-sheet peptide, as target system, and, as an...

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Veröffentlicht in:	Journal of molecular biology 2001-09, Vol.312 (1), p.229-246
Hauptverfasser:	López de la Paz, M, Lacroix, E, Ramírez-Alvarado, M, Serrano, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Amino Acid Sequence Circular Dichroism Drug Design Magnetic Resonance Spectroscopy Models, Molecular Molecular Sequence Data Mutation Peptides - chemistry Predictive Value of Tests Protein Conformation Protein Engineering - methods Proteins - chemistry Proteins - genetics
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