Continuous topical administration of a petrolatum formulation by a novel disposable Diaper. 2. Effect on skin condition
Diaper dermatitis is a common childhood affliction. Aiming to help reduce the prevalence of this problem, we have developed a novel diaper to deliver to the skin dermatological formulations intended to help protect the skin from overhydration and irritation. To determine the clinical benefits of a n...
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| Veröffentlicht in: | Dermatology (Basel) 2000, Vol.200 (3), p.238-243 |
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| container_title | Dermatology (Basel) |
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| creator | ODIO, M. R O'CONNOR, R. J SARBAUGH, F BALDWIN, S |
| description | Diaper dermatitis is a common childhood affliction. Aiming to help reduce the prevalence of this problem, we have developed a novel diaper to deliver to the skin dermatological formulations intended to help protect the skin from overhydration and irritation.
To determine the clinical benefits of a novel disposable diaper designed to deliver a petrolatum-based formulation continuously to the skin during use.
Two independent, blinded, randomized clinical trials were conducted, involving an aggregate total of 391 children, 8-24 months of age. All comparisons were done versus a control diaper, identical to the test product except for the absence of the petrolatum formulation. The studies determined the effects of the novel diaper on skin erythema and diaper rash.
Use of the formulation-treated diaper was associated with significant reductions in severity of erythema and diaper rash compared to the control product.
The results demonstrated the clinical benefits associated with continuous topical administration of a petrolatum-based formulation by this novel diaper. We anticipate that this advance in diaper design will contribute significantly to further reduce the prevalence and severity of irritant contact dermatitis in the diaper area. |
| doi_str_mv | 10.1159/000018366 |
| format | Article |
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To determine the clinical benefits of a novel disposable diaper designed to deliver a petrolatum-based formulation continuously to the skin during use.
Two independent, blinded, randomized clinical trials were conducted, involving an aggregate total of 391 children, 8-24 months of age. All comparisons were done versus a control diaper, identical to the test product except for the absence of the petrolatum formulation. The studies determined the effects of the novel diaper on skin erythema and diaper rash.
Use of the formulation-treated diaper was associated with significant reductions in severity of erythema and diaper rash compared to the control product.
The results demonstrated the clinical benefits associated with continuous topical administration of a petrolatum-based formulation by this novel diaper. We anticipate that this advance in diaper design will contribute significantly to further reduce the prevalence and severity of irritant contact dermatitis in the diaper area.</description><identifier>ISSN: 1018-8665</identifier><identifier>EISSN: 1421-9832</identifier><identifier>DOI: 10.1159/000018366</identifier><identifier>PMID: 10828633</identifier><language>eng</language><publisher>Basel: Karger</publisher><subject>Administration, Topical ; Analysis of Variance ; Biological and medical sciences ; Child, Preschool ; Diaper Rash - pathology ; Diaper Rash - prevention & control ; Double-Blind Method ; Erythema - pathology ; Erythema - prevention & control ; Female ; Humans ; Infant ; Infant Care ; Male ; Medical sciences ; Ointment Bases - therapeutic use ; Petrolatum - therapeutic use ; Pharmacology. Drug treatments ; Severity of Illness Index ; Skin - drug effects ; Skin - pathology ; Skin, nail, hair, dermoskeleton ; Time Factors</subject><ispartof>Dermatology (Basel), 2000, Vol.200 (3), p.238-243</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright 2000 S. Karger AG, Basel.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1402882$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10828633$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ODIO, M. R</creatorcontrib><creatorcontrib>O'CONNOR, R. J</creatorcontrib><creatorcontrib>SARBAUGH, F</creatorcontrib><creatorcontrib>BALDWIN, S</creatorcontrib><title>Continuous topical administration of a petrolatum formulation by a novel disposable Diaper. 2. Effect on skin condition</title><title>Dermatology (Basel)</title><addtitle>Dermatology</addtitle><description>Diaper dermatitis is a common childhood affliction. Aiming to help reduce the prevalence of this problem, we have developed a novel diaper to deliver to the skin dermatological formulations intended to help protect the skin from overhydration and irritation.
To determine the clinical benefits of a novel disposable diaper designed to deliver a petrolatum-based formulation continuously to the skin during use.
Two independent, blinded, randomized clinical trials were conducted, involving an aggregate total of 391 children, 8-24 months of age. All comparisons were done versus a control diaper, identical to the test product except for the absence of the petrolatum formulation. The studies determined the effects of the novel diaper on skin erythema and diaper rash.
Use of the formulation-treated diaper was associated with significant reductions in severity of erythema and diaper rash compared to the control product.
The results demonstrated the clinical benefits associated with continuous topical administration of a petrolatum-based formulation by this novel diaper. We anticipate that this advance in diaper design will contribute significantly to further reduce the prevalence and severity of irritant contact dermatitis in the diaper area.</description><subject>Administration, Topical</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Child, Preschool</subject><subject>Diaper Rash - pathology</subject><subject>Diaper Rash - prevention & control</subject><subject>Double-Blind Method</subject><subject>Erythema - pathology</subject><subject>Erythema - prevention & control</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant Care</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Ointment Bases - therapeutic use</subject><subject>Petrolatum - therapeutic use</subject><subject>Pharmacology. Drug treatments</subject><subject>Severity of Illness Index</subject><subject>Skin - drug effects</subject><subject>Skin - pathology</subject><subject>Skin, nail, hair, dermoskeleton</subject><subject>Time Factors</subject><issn>1018-8665</issn><issn>1421-9832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LAzEQhoMotlYP_gHJQbxtzcduNnuUWj-g4EXPJckmEM0ma5JV-u-NtOJc5mXeZwbmBeASoyXGTXeLSmFOGTsCc1wTXHWckuOiy7TijDUzcJbSe6EIb7tTMMOIE84onYPvVfDZ-ilMCeYwWiUcFP1gvU05imyDh8FAAUedY3AiTwM0IQ6T23tyVzwfvrSDvU1jSEI6De-tGHVcQrKEa2O0yrCg6cN6qILv7e_mOTgxwiV9cegL8Pawfl09VZuXx-fV3aYaCWW50qijlEjV9B0hiGLBaYdrzk2DhOprKmVrUMNaURzEsERtLVkRvWZE1VzQBbjZ3x1j-Jx0ytvBJqWdE16Xn7dtCRATygt4dQAnOeh-O0Y7iLjb_kVVgOsDIFJJyUThlU3_XF3C5YT-AObydt0</recordid><startdate>2000</startdate><enddate>2000</enddate><creator>ODIO, M. R</creator><creator>O'CONNOR, R. J</creator><creator>SARBAUGH, F</creator><creator>BALDWIN, S</creator><general>Karger</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2000</creationdate><title>Continuous topical administration of a petrolatum formulation by a novel disposable Diaper. 2. Effect on skin condition</title><author>ODIO, M. R ; O'CONNOR, R. J ; SARBAUGH, F ; BALDWIN, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p236t-e09332bc5d922031a8391488f50acd43bb7f0567a1a8061b074b6061de62c48a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Administration, Topical</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Child, Preschool</topic><topic>Diaper Rash - pathology</topic><topic>Diaper Rash - prevention & control</topic><topic>Double-Blind Method</topic><topic>Erythema - pathology</topic><topic>Erythema - prevention & control</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant Care</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Ointment Bases - therapeutic use</topic><topic>Petrolatum - therapeutic use</topic><topic>Pharmacology. Drug treatments</topic><topic>Severity of Illness Index</topic><topic>Skin - drug effects</topic><topic>Skin - pathology</topic><topic>Skin, nail, hair, dermoskeleton</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ODIO, M. R</creatorcontrib><creatorcontrib>O'CONNOR, R. J</creatorcontrib><creatorcontrib>SARBAUGH, F</creatorcontrib><creatorcontrib>BALDWIN, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Dermatology (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ODIO, M. R</au><au>O'CONNOR, R. J</au><au>SARBAUGH, F</au><au>BALDWIN, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Continuous topical administration of a petrolatum formulation by a novel disposable Diaper. 2. Effect on skin condition</atitle><jtitle>Dermatology (Basel)</jtitle><addtitle>Dermatology</addtitle><date>2000</date><risdate>2000</risdate><volume>200</volume><issue>3</issue><spage>238</spage><epage>243</epage><pages>238-243</pages><issn>1018-8665</issn><eissn>1421-9832</eissn><abstract>Diaper dermatitis is a common childhood affliction. Aiming to help reduce the prevalence of this problem, we have developed a novel diaper to deliver to the skin dermatological formulations intended to help protect the skin from overhydration and irritation.
To determine the clinical benefits of a novel disposable diaper designed to deliver a petrolatum-based formulation continuously to the skin during use.
Two independent, blinded, randomized clinical trials were conducted, involving an aggregate total of 391 children, 8-24 months of age. All comparisons were done versus a control diaper, identical to the test product except for the absence of the petrolatum formulation. The studies determined the effects of the novel diaper on skin erythema and diaper rash.
Use of the formulation-treated diaper was associated with significant reductions in severity of erythema and diaper rash compared to the control product.
The results demonstrated the clinical benefits associated with continuous topical administration of a petrolatum-based formulation by this novel diaper. We anticipate that this advance in diaper design will contribute significantly to further reduce the prevalence and severity of irritant contact dermatitis in the diaper area.</abstract><cop>Basel</cop><pub>Karger</pub><pmid>10828633</pmid><doi>10.1159/000018366</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 1018-8665 |
| ispartof | Dermatology (Basel), 2000, Vol.200 (3), p.238-243 |
| issn | 1018-8665 1421-9832 |
| language | eng |
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| source | Karger Journals; MEDLINE |
| subjects | Administration, Topical Analysis of Variance Biological and medical sciences Child, Preschool Diaper Rash - pathology Diaper Rash - prevention & control Double-Blind Method Erythema - pathology Erythema - prevention & control Female Humans Infant Infant Care Male Medical sciences Ointment Bases - therapeutic use Petrolatum - therapeutic use Pharmacology. Drug treatments Severity of Illness Index Skin - drug effects Skin - pathology Skin, nail, hair, dermoskeleton Time Factors |
| title | Continuous topical administration of a petrolatum formulation by a novel disposable Diaper. 2. Effect on skin condition |
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